Jeffrey Henderson

Associate Professor of Medicine, Associate Professor of Molecular Microbiology

  • 2541 Citations

Research output per year

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Personal profile

Research interests

The Henderson laboratory uses interdisciplinary approaches to better understand infection pathogenesis and to identify new diagnostic and therapeutic strategies. To do this, we combine patient-oriented studies with new biochemical approaches to identify how virulence-associated bacterial pathogens cause disease. Guided by these results, we seek a mechanistic understanding of infection physiology. Of particular interest are the multifunctional roles of small molecules associated with iron scavenging – called siderophores. New properties and host interactions have been identified for bacterial siderophores using a combination of biochemical and pathophysiologic approaches including mass spectrometry-based metabolomics, bacterial genetics, protein chemistry, and infection models.

Areas of Clinical Interest

Infectious diseases


  • COVID-19

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Research Output

Deployment of convalescent plasma for the prevention and treatment of COVID-19

Bloch, E. M., Shoham, S., Casadevall, A., Sachais, B. S., Shaz, B., Winters, J. L., Van Buskirk, C., Grossman, B. J., Joyner, M., Henderson, J. P., Pekosz, A., Lau, B., Wesolowski, A., Katz, L., Shan, H., Auwaerter, P. G., Thomas, D., Sullivan, D. J., Paneth, N., Gehrie, E. & 7 others, Spitalnik, S., Hod, E. A., Pollack, L., Nicholson, W. T., Pirofski, L. A., Bailey, J. A. & Tobian, A. A. R., Jun 1 2020, In : Journal of Clinical Investigation. 130, 6, p. 2757-2765 9 p.

Research output: Contribution to journalReview article

  • 42 Scopus citations

    Site-Specific Siderocalin Binding to Ferric and Ferric-Free Enterobactin As Revealed by Mass Spectrometry

    Guo, C., Steinberg, L. K., Cheng, M., Song, J. H., Henderson, J. P. & Gross, M. L., May 15 2020, In : ACS Chemical Biology. 15, 5, p. 1154-1160 7 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Metabolomic networks connect host-microbiome processes to human Clostridioides difficile infections

    Robinson, J. I., Weir, W. H., Crowley, J. R., Hink, T., Reske, K. A., Kwon, J. H., Burnham, C. A. D., Dubberke, E. R., Mucha, P. J. & Henderson, J. P., Sep 3 2019, In : Journal of Clinical Investigation. 129, 9, p. 3792-3806 15 p.

    Research output: Contribution to journalArticle

    Open Access
  • 7 Scopus citations

    The widely used antimicrobial triclosan induces high levels of antibiotic tolerance in vitro and reduces antibiotic efficacy up to 100-fold in vivo

    Westfall, C., Flores-Mireles, A. L., Robinson, J. I., Lynch, A. J. L., Hultgren, S., Henderson, J. P. & Levin, P. A., May 2019, In : Antimicrobial agents and chemotherapy. 63, 5, e02312-18.

    Research output: Contribution to journalArticle

    Open Access
  • 14 Scopus citations

    A mass spectrometry based transport assay for studying EmrE transport of unlabeled substrates

    Robinson, A. E., Henderson, J. P. & Henzler-Wildman, K. A., May 15 2018, In : Analytical Biochemistry. 549, p. 130-135 6 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations