Jeffrey Haspel

2022

Age-Dependent Reduction in Asthmatic Pathology through Reprogramming of Postviral Inflammatory Responses

Hazan, G., Eubanks, A., Gierasch, C., Atkinson, J., Fox, C., Hernandez-Leyva, A., Rosen, A. L., Kau, A. L., Agapov, E., Alexander-Brett, J., Steinberg, D., Kelley, D., White, M., Byers, D., Wu, K., Keeler, S. P., Zhang, Y., Koenitzer, J. R., Eiden, E., Anderson, N., & 2 othersHoltzman, M. J. & Haspel, J., Mar 15 2022, In: Journal of Immunology. 208, 6, p. 1467-1482 16 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Effect of the COVID-19 Lockdown on Asthma Biological Rhythms

Hazan, G., Fox, C., Eiden, E., Anderson, N., Friger, M. & Haspel, J., Apr 2022, In: Journal of Biological Rhythms. 37, 2, p. 152-163 12 p.

Research output: Contribution to journal › Article › peer-review

2019

Diurnal Rhythms Spatially and Temporally Organize Autophagy

Ryzhikov, M., Ehlers, A., Steinberg, D., Xie, W., Oberlander, E., Brown, S., Gilmore, P. E., Townsend, R. R., Lane, W. S., Dolinay, T., Nakahira, K., Choi, A. M. K. & Haspel, J. A., Feb 12 2019, In: Cell Reports. 26, 7, p. 1880-1892.e6

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

Measuring diurnal rhythms in autophagic and proteasomal flux

Ryzhikov, M., Eubanks, A. & Haspel, J. A., 2019, In: Journal of Visualized Experiments. 2019, 151, e60133.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2018

BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes

Ehlers, A., Xie, W., Agapov, E., Brown, S., Steinberg, D., Tidwell, R., Sajol, G., Schutz, R., Weaver, R., Yu, H., Castro, M., Bacharier, L. B., Wang, X., Holtzman, M. J. & Haspel, J. A., Jan 1 2018, In: Mucosal Immunology. 11, 1, p. 97-111 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

81 Scopus citations

Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1

Lananna, B. V., Nadarajah, C. J., Izumo, M., Cedeño, M. R., Xiong, D. D., Dimitry, J., Tso, C. F., McKee, C. A., Griffin, P., Sheehan, P. W., Haspel, J. A., Barres, B. A., Liddelow, S. A., Takahashi, J. S., Karatsoreos, I. N. & Musiek, E. S., Oct 2 2018, In: Cell Reports. 25, 1, p. 1-9.e5

Research output: Contribution to journal › Article › peer-review

Open Access

70 Scopus citations

Establishment of the early cilia preassembly protein complex during motile ciliogenesis

Horani, A., Ustione, A., Huang, T., Firth, A. L., Pan, J., Gunsten, S. P., Haspel, J. A., Piston, D. W. & Brody, S. L., Feb 6 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 6, p. E1221-E1228

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

2017

Clocks stop sugar shock

Haspel, J., Apr 5 2017, In: Science translational medicine. 9, 384, eaan2772.

Research output: Contribution to journal › Article › peer-review

Guidelines for Genome-Scale Analysis of Biological Rhythms

Hughes, M. E., Abruzzi, K. C., Allada, R., Anafi, R., Arpat, A. B., Asher, G., Baldi, P., de Bekker, C., Bell-Pedersen, D., Blau, J., Brown, S., Ceriani, M. F., Chen, Z., Chiu, J. C., Cox, J., Crowell, A. M., DeBruyne, J. P., Dijk, D. J., DiTacchio, L., Doyle, F. J., & 73 othersDuffield, G. E., Dunlap, J. C., Eckel-Mahan, K., Esser, K. A., FitzGerald, G. A., Forger, D. B., Francey, L. J., Fu, Y. H., Gachon, F., Gatfield, D., de Goede, P., Golden, S. S., Green, C., Harer, J., Harmer, S., Haspel, J., Hastings, M. H., Herzel, H., Herzog, E. D., Hoffmann, C., Hong, C., Hughey, J. J., Hurley, J. M., de la Iglesia, H. O., Johnson, C., Kay, S. A., Koike, N., Kornacker, K., Kramer, A., Lamia, K., Leise, T., Lewis, S. A., Li, J., Li, X., Liu, A. C., Loros, J. J., Martino, T. A., Menet, J. S., Merrow, M., Millar, A. J., Mockler, T., Naef, F., Nagoshi, E., Nitabach, M. N., Olmedo, M., Nusinow, D. A., Ptáček, L. J., Rand, D., Reddy, A. B., Robles, M. S., Roenneberg, T., Rosbash, M., Ruben, M. D., Rund, S. S. C., Sancar, A., Sassone-Corsi, P., Sehgal, A., Sherrill-Mix, S., Skene, D. J., Storch, K. F., Takahashi, J. S., Ueda, H. R., Wang, H., Weitz, C., Westermark, P. O., Wijnen, H., Xu, Y., Wu, G., Yoo, S. H., Young, M., Zhang, E. E., Zielinski, T. & Hogenesch, J. B., Oct 1 2017, In: Journal of Biological Rhythms. 32, 5, p. 380-393 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

127 Scopus citations

Long noncoding RNA FOXD3-AS1 regulates oxidative stress-induced apoptosis via sponging microRNA-150

Zhang, D., Lee, H., Haspel, J. A. & Jin, Y., Oct 2017, In: FASEB Journal. 31, 10, p. 4472-4481 10 p.

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

2016

MicroRNA-15a/16 regulates apoptosis of lung epithelial cells after oxidative stress

Cao, Y., Zhang, D., Moon, H. G., Lee, H., Haspel, J. A., Hu, K., Xie, L. & Jin, Y., 2016, In: Molecular Medicine. 22, p. 233-243 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2014

Circadian rhythm reprogramming during lung inflammation

Haspel, J. A., Chettimada, S., Shaik, R. S., Chu, J. H., Raby, B. A., Cernadas, M., Carey, V., Process, V., Hunninghake, G. M., Ifedigbo, E., Lederer, J. A., Englert, J., Pelton, A., Coronata, A., Fredenburgh, L. E. & Choi, A. M. K., Sep 11 2014, In: Nature communications. 5, 4753.

Research output: Contribution to journal › Article › peer-review

Open Access

107 Scopus citations

Metabolomic derangements are associated with mortality in critically ill adult patients

Rogers, A. J., McGeachie, M., Baron, R. M., Gazourian, L., Haspel, J. A., Nakahira, K., Fredenburgh, L. E., Hunninghake, G. M., Raby, B. A., Matthay, M. A., Otero, R. M., Fowler, V. G., Rivers, E. P., Woods, C. W., Kingsmore, S., Langley, R. J. & Choi, A. M. K., Jan 30 2014, In: PloS one. 9, 1, e87538.

Research output: Contribution to journal › Article › peer-review

Open Access

95 Scopus citations

2013

Autophagic flux and oxidative capacity of skeletal muscles during acute starvation

Mofarrahi, M., Guo, Y., Haspel, J. A., Choi, A. M. K., Davis, E. C., Gouspillou, G., Hepple, R. T., Godin, R., Burelle, Y. & Hussain, S. N. A., Oct 2013, In: Autophagy. 9, 10, p. 1604-1620 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

Histone deacetylase 6-mediated selective autophagy regulates copd-associated cilia dysfunction

Lam, H. C., Cloonan, S. M., Bhashyam, A. R., Haspel, J. A., Singh, A., Sathirapongsasuti, J. F., Cervo, M., Yao, H., Chung, A. L., Mizumura, K., An, C. H., Shan, B., Franks, J. M., Haley, K. J., Owen, C. A., Tesfaigzi, Y., Washko, G. R., Quackenbush, J., Silverman, E. K., Rahman, I., & 5 othersKim, H. P., Mahmood, A., Biswal, S. S., Ryter, S. W. & Choi, A. M. K., Dec 2 2013, In: Journal of Clinical Investigation. 123, 12, p. 5212-5230 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

225 Scopus citations

Syndecan-2 exerts antifibrotic effects by promoting caveolin-1-mediated transforming growth factor-b receptor i internalization and inhibiting transforming growth factor-b1 signaling

Shi, Y., Gochuico, B. R., Yu, G., Tang, X., Osorio, J. C., Fernandez, I. E., Risquez, C. F., Patel, A. S., Shi, Y., Wathelet, M. G., Goodwin, A. J., Haspel, J. A., Ryter, S. W., Billings, E. M., Kaminski, N., Morse, D. & Rosas, I. O., Oct 1 2013, In: American journal of respiratory and critical care medicine. 188, 7, p. 831-841 11 p.

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

2012

Autophagy in idiopathic pulmonary fibrosis

Patel, A. S., Lin, L., Geyer, A., Haspel, J. A., An, C. H., Cao, J., Rosas, I. O. & Morse, D., Jul 18 2012, In: PloS one. 7, 7, e41394.

Research output: Contribution to journal › Article › peer-review

Open Access

280 Scopus citations

Autophagy in pulmonary diseases

Ryter, S. W., Nakahira, K., Haspel, J. A. & Choi, A. M. K., 2012, In: Annual review of physiology. 74, p. 377-401 25 p.

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Inflammasome-regulated cytokines are critical mediators of acute lung injury

Dolinay, T., Kim, Y. S., Howrylak, J., Hunninghake, G. M., An, C. H., Fredenburgh, L., Massaro, A. F., Rogers, A., Gazourian, L., Nakahira, K., Haspel, J. A., Landazury, R., Eppanapally, S., Christie, J. D., Meyer, N. J., Ware, L. B., Christiani, D. C., Ryter, S. W., Baron, R. M. & Choi, A. M. K., Jun 1 2012, In: American journal of respiratory and critical care medicine. 185, 11, p. 1225-1234 10 p.

Research output: Contribution to journal › Article › peer-review

402 Scopus citations

2011

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S. J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., Fitzgerald, K. A., Ryter, S. W. & Choi, A. M. K., Mar 2011, In: Nature immunology. 12, 3, p. 222-230 9 p.

Research output: Contribution to journal › Article › peer-review

2091 Scopus citations

Characterization of macroautophagic flux in vivo using a leupeptin-based assay

Haspel, J., Shaik, R. S., Ifedigbo, E., Nakahira, K., Dolinay, T., Englert, J. A. & Choi, A. M. K., Jun 2011, In: Autophagy. 7, 6, p. 629-642 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

114 Scopus citations

2009

Long-term anticoagulant therapy for idiopathic pulmonary embolism in the elderly: A decision analysis

Haspel, J., Bauer, K., Goehler, A. & Roberts, D. H., May 1 2009, In: CHEST. 135, 5, p. 1243-1251 9 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

2002

L1 mediated homophilic binding and neurite outgrowth are modulated by alternative splicing of exon 2

Jacob, J., Haspel, J., Kane-Goldsmith, N. & Grumet, M., 2002, In: Journal of Neurobiology. 51, 3, p. 177-189 13 p.

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

2001

Cell adhesion molecule L1 in folded (horseshoe) and extended conformations

Schürmann, G., Haspel, J., Grumet, M. & Erickson, H. P., 2001, In: Molecular biology of the cell. 12, 6, p. 1765-1773 9 p.

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Disulfide-mediated dimerization of L1 Ig domains

Haspel, J., Schrmann, G., Jacob, J., Erickson, H. P. & Grumet, M., Nov 1 2001, In: Journal of Neuroscience Research. 66, 3, p. 347-355 9 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

System for cleavable Fc fusion proteins using tobacco etch virus (TEV) protease

Haspel, J., Blanco, C., Jacob, J. & Grumet, M., 2001, In: BioTechniques. 30, 1, p. 60-66 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2000

Fast track - Critical and optimal ig domains for promotion of neurite outgrowth by L1/Ng-CAM

Haspel, J., Friedlander, D. R., Ivgy-May, N., Chickramane, S., Roonprapunt, C., Chen, S., Schachner, M. & Grumet, M., Feb 15 2000, In: Journal of Neurobiology. 42, 3, p. 287-302 16 p.

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Selective expression of Cre recombinase in skeletal muscle fibers

Bothe, G. W. M., Haspel, J. A., Smith, C. L., Wiener, H. H. & Burden, S. J., Feb 2000, In: Genesis. 26, 2, p. 165-166 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

114 Scopus citations

Jeffrey Haspel

Research output

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