• 5372 Citations

Research output per year

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Personal profile

Research interests

We are interested in why patients with severe sepsis develop cellular changes that suggest a failure of cellular housekeeping, which might explain why organ failure ensues in these individuals. A major hypothesis of the lab is that autophagy, a catabolic mechanism involving lysosomal degradation becomes reprogrammed during sepsis and contributes to the changes in cellular composition. An unexpected finding is that autophagy is powerfully influenced by circadian rhythms. Our research seeks to understand the connection between circadian disruption during sepsis and the reprogramming of autophagy. We hope this research will lead to better functional recoveries after critical illness. We particularly focus on lung injury using animal models and are in the process of extending our observations to blood samples from critically ill patients.

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Research Output

  • 5372 Citations
  • 20 Article
  • 10 Review article
  • 2 Comment/debate

Perfect timing: Circadian rhythms, sleep, and immunity — An NIH workshop summary

Haspel, J. A., Anafi, R., Brown, M. K., Cermakian, N., Depner, C., Desplats, P., Gelman, A. E., Haack, M., Jelic, S., Kim, B. S., Laposky, A. D., Lee, Y. C., Mongodin, E., Prather, A. A., Prendergast, B., Reardon, C., Shaw, A. C., Sengupta, S., Szentirmai, É., Thakkar, M. & 2 others, Walker, W. E. & Solt, L. A., 2020, In : JCI Insight. 5, 1, e131487.

Research output: Contribution to journalReview article

Open Access
  • 11 Scopus citations

    Why Lungs Keep Time: Circadian Rhythms and Lung Immunity

    Nosal, C., Ehlers, A. & Haspel, J. A., Jan 1 2020, In : Annual Review of Physiology. 82, p. 391-412 22 p.

    Research output: Contribution to journalReview article

  • 2 Scopus citations

    Adventures in spacetime: circadian rhythms and the dynamics of protein catabolism

    Ryzhikov, M., Ehlers, A. & Haspel, J. A., Jun 3 2019, In : Autophagy. 15, 6, p. 1115-1116 2 p.

    Research output: Contribution to journalComment/debate

  • Diurnal Rhythms Spatially and Temporally Organize Autophagy

    Ryzhikov, M., Ehlers, A., Steinberg, D., Xie, W., Oberlander, E., Brown, S., Gilmore, P. E., Townsend, R. R., Lane, W. S., Dolinay, T., Nakahira, K., Choi, A. M. K. & Haspel, J. A., Feb 12 2019, In : Cell Reports. 26, 7, p. 1880-1892.e6

    Research output: Contribution to journalArticle

    Open Access
  • 13 Scopus citations

    Measuring Diurnal Rhythms in Autophagic and Proteasomal Flux

    Ryzhikov, M., Eubanks, A. & Haspel, J. A., Sep 17 2019, In : Journal of visualized experiments : JoVE. 151

    Research output: Contribution to journalArticle