Research output per year
Research output per year
Personal profile
Research interests
Our research focuses on the signals important in early lymphocyte development, specifically how DNA damage responses integrated with cytokine signals to direct differentiation and maturation. We study cellular pathways triggered by physiologic and genotoxic DNA breaks and how these signals balance survival, cell death and developmental programs to ensure that lymphocytes make functional antigen receptors and continue development. These mechanisms are critical for maintaining genomic integrity and errors in these pathways can lead to translocations and leukemogenesis.
Clinical interests
Pediatric cancer, pediatric hematology, pediatric oncology, pediatric brain tumors.
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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Allogeneic hematopoietic cell transplantation is effective for p47phox chronic granulomatous disease: A Primary Immune Deficiency Treatment Consortium study
Grunebaum, E., Arnold, D. E., Logan, B., Parikh, S., Marsh, R. A., Griffith, L. M., Mallhi, K., Chellapandian, D., Lim, S. S., Deal, C. L., Kapoor, N., Murguía-Favela, L., Falcone, E. L., Prasad, V. K., Touzot, F., Bleesing, J. J., Chandrakasan, S., Heimall, J. R., Bednarski, J. J. & Broglie, L. A. & 21 others, , May 2024, In: Journal of Allergy and Clinical Immunology. 153, 5, p. 1423-1431.e2Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Antiviral cellular therapy for enhancing T-cell reconstitution before or after hematopoietic stem cell transplantation (ACES): a two-arm, open label phase II interventional trial of pediatric patients with risk factor assessment
Keller, M. D., Hanley, P. J., Chi, Y. Y., Aguayo-Hiraldo, P., Dvorak, C. C., Verneris, M. R., Kohn, D. B., Pai, S. Y., Dávila Saldaña, B. J., Hanisch, B., Quigg, T. C., Adams, R. H., Dahlberg, A., Chandrakasan, S., Hasan, H., Malvar, J., Jensen-Wachspress, M. A., Lazarski, C. A., Sani, G. & Idso, J. M. & 29 others, , Dec 2024, In: Nature communications. 15, 1, 3258.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Cutting Edge: The Tetraspanin CD53 Promotes CXCR4 Signaling and Bone Marrow Homing in B Cells
Chakraborty, M., Greenberg, Z. J., Dong, Q., Roundy, N., Bednarski, J. J., Paracatu, L. C., Duncavage, E., Li, W. & Schuettpelz, L. G., Apr 1 2024, In: Journal of Immunology. 212, 7, p. 1075-1080 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Letermovir as cytomegalovirus prophylaxis in children undergoing allogeneic hematopoietic cell transplantation
Pfeiffer, T., Lockowitz, C. R., Shenoy, S., Mavers, M., Hayashi, R., Bednarski, J. & Green, A., Aug 2024, In: Bone Marrow Transplantation. 59, 8, p. 1193-1195 3 p.Research output: Contribution to journal › Letter › peer-review
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MYSM1 attenuates DNA damage signals triggered by physiologic and genotoxic DNA breaks
Mathias, B., O'Leary, D., Saucier, N., Ahmad, F., White, L. S., Russell, L. M., Shinawi, M., Smith, M. J., Abraham, R. S., Cooper, M. A., Kitcharoensakkul, M., Green, A. M. & Bednarski, J. J., Apr 2024, In: Journal of Allergy and Clinical Immunology. 153, 4, p. 1113-1124.e7Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations