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Personal profile

Research interests

Our research focuses on the signals important in early lymphocyte development, specifically how DNA damage responses integrated with cytokine signals to direct differentiation and maturation.  We study cellular pathways triggered by physiologic and genotoxic DNA breaks and how these signals balance survival, cell death and developmental programs to ensure that lymphocytes make functional antigen receptors and continue development.  These mechanisms are critical for maintaining genomic integrity and errors in these pathways can lead to translocations and leukemogenesis.

Areas of Clinical Interest

Pediatric cancer, pediatric hematology, pediatric oncology, pediatric brain tumors. 

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Research Output

  • 905 Citations
  • 27 Article
  • 3 Comment/debate
  • 2 Chapter
  • 2 Review article
  • 2 Scopus citations

    DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner

    Collins, P. L., Purman, C., Porter, S. I., Nganga, V., Saini, A., Hayer, K. E., Gurewitz, G. L., Sleckman, B. P., Bednarski, J. J., Bassing, C. H. & Oltz, G., Dec 1 2020, In : Nature communications. 11, 1, 3158.

    Research output: Contribution to journalArticle

    Open Access
  • Hematopoietic Cell Transplantation in Patients With Primary Immune Regulatory Disorders (PIRD): A Primary Immune Deficiency Treatment Consortium (PIDTC) Survey

    Chan, A. Y., Leiding, J. W., Liu, X., Logan, B. R., Burroughs, L. M., Allenspach, E. J., Skoda-Smith, S., Uzel, G., Notarangelo, L. D., Slatter, M., Gennery, A. R., Smith, A. R., Pai, S. Y., Jordan, M. B., Marsh, R. A., Cowan, M. J., Dvorak, C. C., Craddock, J. A., Prockop, S. E., Chandrakasan, S. & 40 others, Kapoor, N., Buckley, R. H., Parikh, S., Chellapandian, D., Oshrine, B. R., Bednarski, J. J., Cooper, M. A., Shenoy, S., Davila Saldana, B. J., Forbes, L. R., Martinez, C., Haddad, E., Shyr, D. C., Chen, K., Sullivan, K. E., Heimall, J., Wright, N., Bhatia, M., Cuvelier, G. D. E., Goldman, F. D., Meyts, I., Miller, H. K., Seidel, M. G., Vander Lugt, M. T., Bacchetta, R., Weinacht, K. G., Andolina, J. R., Caywood, E., Chong, H., de la Morena, M. T., Aquino, V. M., Shereck, E., Walter, J. E., Dorsey, M. J., Seroogy, C. M., Griffith, L. M., Kohn, D. B., Puck, J. M., Pulsipher, M. A. & Torgerson, T. R., Feb 21 2020, In : Frontiers in immunology. 11, 239.

    Research output: Contribution to journalArticle

    Open Access
  • Incidence and treatment of hemophagocytic lymphohistiocytosis in hospitalized children with Ehrlichia infection

    Cabler, S. S., Hogan, P. G., Fritz, S. A., Bednarski, J. & Hunstad, D., 2020, (Accepted/In press) In : Pediatric Blood and Cancer.

    Research output: Contribution to journalArticle

  • Neuroinflammatory Disease as an Isolated Manifestation of Hemophagocytic Lymphohistiocytosis

    Blincoe, A., Heeg, M., Campbell, P. K., Hines, M., Khojah, A., Klein-Gitelman, M., Talano, J. A., Speckmann, C., Touzot, F., Lankester, A., Legger, G. E., Rivière, J. G., Garcia-Prat, M., Alonso, L., Putti, M. C., Lehmberg, K., Maier, S., El Chazli, Y., Elmaksoud, M. A., Astigarraga, I. & 21 others, Kurjane, N., Bulina, I., Kenina, V., Bryceson, Y., Rascon, J., Lortie, A., Goldstein, G., Booth, C., Worth, A., Wassmer, E., Schmitt, E. G., Warren, J. T., Bednarski, J. J., Ali, S., Chiang, K. Y., Krueger, J., Henry, M. M., Holland, S. M., Marsh, R. A., Ehl, S. & Haddad, E., Aug 1 2020, In : Journal of Clinical Immunology. 40, 6, p. 901-916 16 p.

    Research output: Contribution to journalArticle