Jeffrey Atkinson

Associate Professor of Medicine, Associate Professor of Pediatrics

    • 1801 Citations
    20032019

    Research output per year

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    Personal profile

    Research interests

    My lab researches the role of proteases in the development of lung diseases. We are involved in both basic science and clinical translational research in obstructive lung diseases with a special interest in COPD, cystic fibrosis, ciliary dyskinesia and idiopathic bronchiectasis. We utilize mouse models including smoke exposure of gene targeted mice to better understand human disease. In addition we are involved in translational research into monocyte/alveolar macrophage function in smokers with and without emphysema and genetic polymorphisms that correlate with these functional alterations. Our lab also is involved in therapeutic (Phase I-III) trials in bronchiectatic lung disease with a predominant interest in pharmaceutical treatments for chronic Pseudomonal infection in cystic fibrosis.

    Areas of Clinical Interest

    Cystic fibrosis, ciliary dyskinesia

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    Research Output

    De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with Hydrocephalus and Randomization of Left/Right Body Asymmetry

    Wallmeier, J., Frank, D., Shoemark, A., Nöthe-Menchen, T., Cindric, S., Olbrich, H., Loges, N. T., Aprea, I., Dougherty, G. W., Pennekamp, P., Kaiser, T., Mitchison, H. M., Hogg, C., Carr, S. B., Zariwala, M. A., Ferkol, T., Leigh, M. W., Davis, S. D., Atkinson, J., Dutcher, S. K. & 10 others, Knowles, M. R., Thiele, H., Altmüller, J., Krenz, H., Wöste, M., Brentrup, A., Ahrens, F., Vogelberg, C., Morris-Rosendahl, D. J. & Omran, H., Nov 7 2019, In : American journal of human genetics. 105, 5, p. 1030-1039 10 p.

    Research output: Contribution to journalArticle

  • 11 Scopus citations

    Factors Associated with Mortality and Response to Extracorporeal Photopheresis in Lung Allograft Recipients with Bronchiolitis Obliterans Syndrome

    Karnes, H. E., Schindler, E. I., Morrell, M., Hachem, R. R., Berman, K., Vedantham, S., Atkinson, J., Spitznagel, E. & Despotis, G. J., May 1 2019, In : Transplantation. 103, 5, p. 1036-1042 7 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Lumacaftor/ivacaftor in patients with cystic fibrosis and advanced lung disease homozygous for F508del-CFTR

    VX14-809-106 Investigator Group, Mar 2018, In : Journal of Cystic Fibrosis. 17, 2, p. 228-235 8 p.

    Research output: Contribution to journalArticle

    Open Access
  • 29 Scopus citations
  • 1 Scopus citations

    Mechanisms Underlying HIV-Associated Noninfectious Lung Disease

    Presti, R. M., Flores, S. C., Palmer, B. E., Atkinson, J. J., Lesko, C. R., Lau, B., Fontenot, A. P., Roman, J., McDyer, J. F. & Twigg, H. L., Nov 2017, In : CHEST. 152, 5, p. 1053-1060 8 p.

    Research output: Contribution to journalReview article

  • 13 Scopus citations