• 16863 Citations
1990 …2020

Research output per year

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Personal profile

Research interests

My laboratory uses basic science approaches to investigate clinically relevant issues. The first deals with the role of the glomerular basement membrane in kidney function and disease. We study the laminin, type IV collagen, and proteoglycan components of the basement membrane to understand how they function in glomerular filtration. We use two mouse models that serve as models for human kidney disease. Col4a3-/- mice lack the type IV collagen alpha3 chain and model Alport syndrome, or hereditary glomerulonephritis. Lamb2-/- mice lack the laminin beta2 chain and model Pierson syndrome, a form of congenital nephrotic syndrome. We are using these mice to determine how abnormalities in the glomerular basement membrane affect its intrinsic permeability and its signaling to the adjacent epithelial and endothelial cells.

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Research Output

A deletion in the N-terminal polymerizing domain of laminin β2 is a new mouse model of chronic nephrotic syndrome

Funk, S. D., Bayer, R. H., McKee, K. K., Okada, K., Nishimune, H., Yurchenco, P. D. & Miner, J. H., Jan 1 2020, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

  • Basement membrane ligands initiate distinct signalling networks to direct cell shape

    Randles, M. J., Lausecker, F., Humphries, J. D., Byron, A., Clark, S. J., Miner, J. H., Zent, R., Humphries, M. J. & Lennon, R., Jan 1 2020, (Accepted/In press) In : Matrix Biology.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    Clinical trial recommendations for potential Alport syndrome therapies

    Weinstock, B. A., Feldman, D. L., Fornoni, A., Gross, O., Kashtan, C. E., Lagas, S., Lennon, R., Miner, J. H., Rheault, M. N., Simon, J. F., Bonebrake, L., Dunleavy, M., Kumnick, P., Parziale, G., Reed, J., Weinstock, A., Gear, S., Binaso, K., Manuel, R., Simon, J. & 35 others, Appel, G., Blank, M., Tang, W., Thompson, A., Torra, R., Lieberman, K., Licht, C., Dahan, K., Nozu, K., Kai, H., Ricardo, S., Pariser, A., Feldman, D., Cook, H., Chin, M., Goldsberry, A., Meyer, C., Melia, L. A., Komers, R., Markels, M., Mercer, A., Prunotto, M., Morgenstern, B., Hariri, A., Modur, V., Turner, N., Kashtan, C., Rheault, M., Baigent, C., DeSacco, S., Perin, L., Barua, M., Nakanishi, K., Jarad, G. & Miner, J., Jun 2020, In : Kidney International. 97, 6, p. 1109-1116 8 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress

    Delitsikou, V., Jarad, G., Rajaram, R. D., Ino, F., Rutkowski, J. M., Chen, C. D., Santos, C. X. C., Scherer, P. E., Abraham, C. R., Shah, A. M., Feraille, E., Miner, J. H. & de Seigneux, S., Feb 1 2020, In : FASEB Journal. 34, 2, p. 2087-2104 18 p.

    Research output: Contribution to journalArticle

    Open Access
  • Mammalian hemicentin 1 is assembled into tracks in the extracellular matrix of multiple tissues

    Lin, M. H., Pope, B. D., Sasaki, T., Keeley, D. P., Sherwood, D. R. & Miner, J. H., Jun 1 2020, In : Developmental Dynamics. 249, 6, p. 775-788 14 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations