Personal profile
Research interests
The research program in this laboratory is focused on defining the mechanisms involved in the physiological regulation of membrane excitability in cardiac and neuronal cells and the derangements in membrane excitability that are associated with disease. One focus of our work is on exploring the functioning and the regulation of a diverse class of potassium (K+) selective membrane ion channels that are gated by changes in membrane voltage. Additional ongoing studies are aimed at delineating the mechanisms underlying changes in the expression, trafficking and localization of these channels associated with cardiovascular and metabolic diseases and at defining the functional consequences of these changes.
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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In Vivo Expression of an SCA27A-Linked FGF14 Mutation Results in Haploinsufficiency and Impaired Firing of Cerebellar Purkinje Neurons
Ransdell, J. L., Brown, S. P., Xiao, M., Ornitz, D. M. & Nerbonne, J. M., Feb 18 2026, In: Journal of Neuroscience. 46, 7, e2016242026.Research output: Contribution to journal › Article › peer-review
Open Access -
Senolytic reduction of senescent cells mitigates atrial arrhythmia vulnerability in aging rabbits
Sengun, E., Zhou, L., Kelsey, M., Turan, N. N., Lu, Y., Kabakov, A. Y., Bronk, P., Mi, E., Kim, T. Y., Vijayakumar, S., Price, D., Nussbaum, S. S., Song, C., Feng, J., Sellke, F. W., Dubielecka-Szczerba, P., Del Monte, F., Nerbonne, J., Uydes-Dogan, B. S. & Roder, K. & 4 others, , Apr 1 2026, In: Heart rhythm. 23, 4, p. e675-e691Research output: Contribution to journal › Article › peer-review
Open Access -
Loss of intracellular FGF14 (iFGF14) increases excitability of mature hippocampal pyramidal neurons
Ransdell, J. L., Carrasquillo, Y., Bosch, M. K., Mellor, R. L., Ornitz, D. M. & Nerbonne, J. M., Jul 7 2025, In: The Journal of general physiology. 157, 4Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Novel coenzyme Q6 genetic variant increases susceptibility to pneumococcal disease
Walker, E. C., Javati, S., Todd, E. M., Matlam, J. P., Lin, X., Bryant, M., Krone, E., Ramani, R., Chandra, P., Green, T. P., Anaya, E. P., Zhou, J. Y., Alexander, K. A., Tong, R. S., Yuasi, L., Boluarte, S., Yang, F., Greenberg, L., Nerbonne, J. M. & Greenberg, M. J. & 10 others, , Dec 2024, In: Nature immunology. 25, 12, p. 2247-2258 12 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations -
Transcutaneous Red-Light and Low-Power Density Optogenetic Control of a ReaChR-Expressing Mouse Heart
Amaral, M. M., Matt, A., Wang, F., Gracheva, E., Liang, H., Kovacs, A., Weinheimer, C., Diwan, A., Cui, J., Rentchler, S., Nerbonne, J., Zemlin, C. & Zhou, C., 2024.Research output: Contribution to conference › Paper › peer-review