Jeanne Nerbonne

Professor of Medicine, Alumni Endowed Professor of Molecular Biology and Pharmacology in Developmental Biology

  • 14798 Citations
1978 …2019
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Personal profile

Research interests

The research program in this laboratory is focused on defining the mechanisms involved in the physiological regulation of membrane excitability in cardiac and neuronal cells and the derangements in membrane excitability that are associated with disease. One focus of our work is on exploring the functioning and the regulation of a diverse class of potassium (K+) selective membrane ion channels that are gated by changes in membrane voltage. Additional ongoing studies are aimed at delineating the mechanisms underlying changes in the expression, trafficking and localization of these channels associated with cardiovascular and metabolic diseases and at defining the functional consequences of these changes.

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Action Potentials Medicine & Life Sciences
Muscle Cells Medicine & Life Sciences
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Voltage-Gated Potassium Channels Medicine & Life Sciences
Cardiac Arrhythmias Medicine & Life Sciences
Atrial Remodeling Medicine & Life Sciences
Ion Channels Medicine & Life Sciences
Myocardium Medicine & Life Sciences

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Research Output 1978 2019

2 Citations (Scopus)

Circulating long noncoding RNA DKFZP434I0714 predicts adverse cardiovascular outcomes in patients with end-stage renal disease

Lai, C. F., Chen, Y. T., Gu, J., Nerbonne, J., Lin, C. H. & Yang, K. C., Feb 15 2019, In : International Journal of Cardiology. 277, p. 212-219 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Long Noncoding RNA
Chronic Kidney Failure
Kidney Diseases
Uremia
RNA Sequence Analysis

Regional differences in the expression of tetrodotoxin-sensitive inward Ca2+ and outward Cs+/K+ currents in mouse and human ventricles

Wang, W., Mellor, R. L., Nerbonne, J. & Balke, B., Jan 1 2019, In : Channels. 13, 1, p. 72-87 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Tetrodotoxin
Muscle Cells
Endocardium
Ventricular Septum
Pericardium
1 Citation (Scopus)

The role of the voltage-gated potassium channel proteins Kv8.2 and Kv2.1 in vision and retinal disease: Insights from the study of mouse gene knock-out mutations

Hart, N. S., Mountford, J. K., Voigt, V., Fuller-Carter, P., Barth, M., Nerbonne, J., Hunt, D. M. & Carvalho, L. S., Jan 1 2019, In : eNeuro. 6, 1, e0032-19.2019.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Voltage-Gated Potassium Channels
Retinal Diseases
Gene Knockout Techniques
Knockout Mice
Mutation
1 Citation (Scopus)

Differential Expression and Remodeling of Transient Outward Potassium Currents in Human Left Ventricles

Johnson, E., Springer, S. J., Wang, W., Dranoff, E. J., Zhang, Y., Kanter, E. M., Yamada, K. A. & Nerbonne, J., Jan 1 2018, In : Circulation. Arrhythmia and electrophysiology. 11, 1, p. e005914

Research output: Contribution to journalArticleResearchpeer-review

Action Potentials
Heart Ventricles
Potassium
Muscle Cells
Animal Models
8 Citations (Scopus)

Endoplasmic reticulum protein TxNDC5 augments myocardial fibrosis by facilitating extracellular matrix protein folding and redox-sensitive cardiac fibroblast activation

Shih, Y. C., Chen, C. L., Zhang, Y., Mellor, R. L., Kanter, E. M., Fang, Y., Wang, H. C., Hung, C. T., Nong, J. Y., Chen, H. J., Lee, T. H., Tseng, Y. S., Chen, C. N., Wu, C. C., Lin, S. L., Yamada, K. A., Nerbonne, J. & Yang, K. C., Jan 1 2018, In : Circulation research. 122, 8, p. 1052-1068 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Thioredoxins
Extracellular Matrix Proteins
Protein Folding
Endoplasmic Reticulum
Oxidation-Reduction