The research program in this laboratory is focused on defining the mechanisms involved in the physiological regulation of membrane excitability in cardiac and neuronal cells and the derangements in membrane excitability that are associated with disease. One focus of our work is on exploring the functioning and the regulation of a diverse class of potassium (K+) selective membrane ion channels that are gated by changes in membrane voltage. Additional ongoing studies are aimed at delineating the mechanisms underlying changes in the expression, trafficking and localization of these channels associated with cardiovascular and metabolic diseases and at defining the functional consequences of these changes.

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