Jean Schaffer

Virginia Minnich Distinguished Professor of Medicine, Professor of Developmental Biology

  • 8174 Citations
1985 …2019
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Personal profile

Research interests

The epidemic of diabetes and obesity presents a formidable challenge because of serious cardiovascular complications of these disorders that includes heart failure. In these diseases, dyslipidemia leads to fatty acid accumulation in non-adipose tissues such as the myocardium, which results in cellular dysfunction and cell death and contributes to organ dysfunction, a process known as lipotoxicity. Dyslipidemia may also contribute to other end organ complications and play a key role in transmitting increased cardiovascular risk to offspring. Our work focuses on characterization of the fundamental cellular mechanisms of lipotoxicity and its role in subsequent organ dysfunction. In rodents, we are exploring the effects of the intrauterine environment on development metabolic syndrome and diabetes in adult offspring. Furthermore, we are characterizing the relationship between altered systemic lipid metabolism and early diabetic cardiomyopathy in human subjects with type 2 diabetes. Our long-term goal is to develop novel lipid biomarkers and non-invasive methods for diagnosing the earliest structural and functional abnormalities in diabetic cardiomyopathy and for guiding therapy.

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  • 4 Similar Profiles
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Research Output 1985 2019

  • 8174 Citations
  • 79 Article
  • 11 Review article
  • 1 Comment/debate
  • 1 Short survey

2-Hydroxypropyl-β-cyclodextrin is the active component in a triple combination formulation for treatment of Niemann-Pick C1 disease

Davidson, J., Molitor, E., Moores, S., Gale, S. E., Subramanian, K., Jiang, X., Sidhu, R., Kell, P., Zhang, J., Fujiwara, H., Davidson, C., Helquist, P., Melancon, B. J., Grigalunas, M., Liu, G., Salahi, F., Wiest, O., Xu, X., Porter, F. D., Pipalia, N. H. & 6 others, Cruz, D. L., Holson, E. B., Schaffer, J., Walkley, S. U., Maxfield, F. R. & Ory, D., Oct 1 2019, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1864, 10, p. 1545-1561 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Niemann-Pick Diseases
Histone Deacetylase Inhibitors
Cyclodextrins
Pharmacokinetics
Type C Niemann-Pick Disease
2 Citations (Scopus)

Diagnosis of niemann-pick C1 by measurement of bile acid biomarkers in archived newborn dried blood spots

Jiang, X., Sidhu, R., Orsini, J. J., Farhat, N. Y., Porter, F. D., Berry-Kravis, E., Schaffer, J. & Ory, D., Feb 1 2019, In : Molecular genetics and metabolism. 126, 2, p. 183-187 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Type C Niemann-Pick Disease
Biomarkers
Bile Acids and Salts
Blood
Newborn Infant

N-acyl-O-phosphocholineserines: Structures of a novel class of lipids that are biomarkers for Niemann-Pick C1 disease

Sidhu, R., Mondjinou, Y., Qian, M., Song, H., Kumar, A. B., Hong, X., Hsu, F., Dietzen, D., Yanjanin, N. M., Porter, F. D., Berry-Kravis, E., Vite, C. H., Gelb, M. H., Schaffer, J., Ory, D. & Jiang, X., Jan 1 2019, In : Journal of lipid research. 60, 8, p. 1410-1424 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Niemann-Pick Diseases
Type C Niemann-Pick Disease
Biomarkers
Lipids
Music

Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking

Feltes, M., Moores, S., Gale, S. E., Krishnan, K., Mydock-McGrane, L., Covey, D., Ory, D. & Schaffer, J., Jan 1 2019, In : Journal of lipid research. 60, 3, p. 707-716 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Diazomethane
Alkynes
Cholesterol
Sterols
Protein Transport

A HILIC-MS/MS method for simultaneous quantification of the lysosomal disease markers galactosylsphingosine and glucosylsphingosine in mouse serum

Sidhu, R., Mikulka, C. R., Fujiwara, H., Sands, M., Schaffer, J., Ory, D. & Jiang, X., Jul 1 2018, In : Biomedical Chromatography. 32, 7, e4235.

Research output: Contribution to journalArticleResearchpeer-review

Psychosine
Gaucher Disease
Serum
Biomarkers
Assays