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Jason Weber

Professor of Medicine, Professor of Cell Biology and Physiology

    • 7937 Citations
    19962019

    Research output per year

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    Personal profile

    Research interests

    My lab is using biochemical and proteomic techniques to identify all protein components of the nucleolus in order to study the nucleolar dynamics of ARF tumor suppression. Related to this goal, we have identified several nucleolar oncoproteins involved in various aspects of ribosome biogenesis. Many of these proteins are overexpressed or amplified in human breast cancers, suggesting that defects in ribsome biogenesis might themselves prove oncogenic. Our goal is to understand the basic mechanisms behind ARF’s tumor suppressive capabilities and to relate these processes to our growing knowledge of human cancer progression. Members of the lab are translating their findings into clinical settings and potential application through numerous collaborations with Internal Medicine faculty.

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    Research Output

    Associations of race and ethnicity with risk of developing invasive breast cancer after lobular carcinoma in situ

    Dania, V., Liu, Y., Ademuyiwa, F., Weber, J. D. & Colditz, G. A., Nov 14 2019, In : Breast Cancer Research. 21, 1, 120.

    Research output: Contribution to journal › Article

    Open Access
    • 3 Scopus citations

    DHX33 interacts with AP-2 to regulate Bcl-2 gene expression and promote cancer cell survival

    Wang, J., Feng, W., Yuan, Z., Weber, J. D. & Zhang, Y., Sep 1 2019, In : Molecular and cellular biology. 39, 17, e00017-19.

    Research output: Contribution to journal › Article

    • 5 Scopus citations

    Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation

    Yao, C. H., Wang, R., Wang, Y., Kung, C. P., Weber, J. D. & Patti, G. J., Jan 29 2019, In : eLife. 8, e41351.

    Research output: Contribution to journal › Article

    Open Access
    • 23 Scopus citations

    Race and risk of subsequent aggressive breast cancer following ductal carcinoma in situ

    Liu, Y., West, R., Weber, J. D. & Colditz, G. A., Sep 15 2019, In : Cancer. 125, 18, p. 3225-3233 9 p.

    Research output: Contribution to journal › Article

    Open Access
    • 1 Scopus citations

    Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer

    Wagner, A. H., Devarakonda, S., Skidmore, Z. L., Krysiak, K., Ramu, A., Trani, L., Kunisaki, J., Masood, A., Waqar, S., Spies, N. C., Morgensztern, D., Waligorski, J., Ponce, J., Fulton, R., Maggi, L., Weber, J., Watson, M., O’Conor, C. J., Ritter, J., Olsen, R. R. & 10 others, Cheng, H., Mukhopadhyay, A., Can, I., Cessna, M. H., Oliver, T. G., Mardis, E. R., Wilson, R. K., Griffith, M., Griffith, O. & Govindan, R., Dec 1 2018, In : Nature communications. 9, 1, 3787.

    Research output: Contribution to journal › Article

    Open Access
    • 23 Scopus citations