• 7937 Citations
19962019

Research output per year

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Personal profile

Research interests

My lab is using biochemical and proteomic techniques to identify all protein components of the nucleolus in order to study the nucleolar dynamics of ARF tumor suppression. Related to this goal, we have identified several nucleolar oncoproteins involved in various aspects of ribosome biogenesis. Many of these proteins are overexpressed or amplified in human breast cancers, suggesting that defects in ribsome biogenesis might themselves prove oncogenic. Our goal is to understand the basic mechanisms behind ARF’s tumor suppressive capabilities and to relate these processes to our growing knowledge of human cancer progression. Members of the lab are translating their findings into clinical settings and potential application through numerous collaborations with Internal Medicine faculty.

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Research Output

Open Access
  • 3 Scopus citations

    DHX33 interacts with AP-2 to regulate Bcl-2 gene expression and promote cancer cell survival

    Wang, J., Feng, W., Yuan, Z., Weber, J. D. & Zhang, Y., Sep 1 2019, In : Molecular and cellular biology. 39, 17, e00017-19.

    Research output: Contribution to journalArticle

  • 5 Scopus citations

    Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation

    Yao, C. H., Wang, R., Wang, Y., Kung, C. P., Weber, J. D. & Patti, G. J., Jan 29 2019, In : eLife. 8, e41351.

    Research output: Contribution to journalArticle

    Open Access
  • 23 Scopus citations

    Race and risk of subsequent aggressive breast cancer following ductal carcinoma in situ

    Liu, Y., West, R., Weber, J. D. & Colditz, G. A., Sep 15 2019, In : Cancer. 125, 18, p. 3225-3233 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer

    Wagner, A. H., Devarakonda, S., Skidmore, Z. L., Krysiak, K., Ramu, A., Trani, L., Kunisaki, J., Masood, A., Waqar, S., Spies, N. C., Morgensztern, D., Waligorski, J., Ponce, J., Fulton, R., Maggi, L., Weber, J., Watson, M., O’Conor, C. J., Ritter, J., Olsen, R. R. & 10 others, Cheng, H., Mukhopadhyay, A., Can, I., Cessna, M. H., Oliver, T. G., Mardis, E. R., Wilson, R. K., Griffith, M., Griffith, O. & Govindan, R., Dec 1 2018, In : Nature communications. 9, 1, 3787.

    Research output: Contribution to journalArticle

    Open Access
  • 23 Scopus citations