Research output per year
Research output per year
Personal profile
Research interests
My lab is using biochemical and proteomic techniques to identify all protein components of the nucleolus in order to study the nucleolar dynamics of ARF tumor suppression. Related to this goal, we have identified several nucleolar oncoproteins involved in various aspects of ribosome biogenesis. Many of these proteins are overexpressed or amplified in human breast cancers, suggesting that defects in ribsome biogenesis might themselves prove oncogenic. Our goal is to understand the basic mechanisms behind ARF’s tumor suppressive capabilities and to relate these processes to our growing knowledge of human cancer progression. Members of the lab are translating their findings into clinical settings and potential application through numerous collaborations with Internal Medicine faculty.
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It’s Getting Complicated—A Fresh Look at p53-MDM2-ARF Triangle in Tumorigenesis and Cancer Therapy
Kung, C. P. & Weber, J. D., Jan 26 2022, In: Frontiers in Cell and Developmental Biology. 10, 818744.Research output: Contribution to journal › Review article › peer-review
Open Access -
Correction to: Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer (Oncogene, (2021), 40, 1, (189-202), 10.1038/s41388-020-01515-5)
Kung, C. P., Cottrell, K. A., Ryu, S., Bramel, E. R., Kladney, R. D., Bao, E. A., Freeman, E. C., Sabloak, T., Maggi, L. & Weber, J. D., Mar 18 2021, In: Oncogene. 40, 11, p. 2147 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer
Kung, C. P., Cottrell, K. A., Ryu, S., Bramel, E. R., Kladney, R. D., Bao, E. A., Freeman, E. C., Sabloak, T., Maggi, L. & Weber, J. D., Jan 7 2021, In: Oncogene. 40, 1, p. 189-202 14 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Evaluation of Racial/Ethnic Differences in Treatment and Mortality among Women with Triple-Negative Breast Cancer
Cho, B., Han, Y., Lian, M., Colditz, G. A., Weber, J. D., Ma, C. & Liu, Y., Jul 2021, In: JAMA oncology. 7, 7, p. 1016-1023 8 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Upregulation of 5′-terminal oligopyrimidine mRNA translation upon loss of the ARF tumor suppressor
Cottrell, K. A., Chiou, R. C. & Weber, J. D., Dec 2020, In: Scientific reports. 10, 1, 22276.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations