Jason Ulrich

2024

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference

Kloske, C. M., Belloy, M. E., Blue, E. E., Bowman, G. R., Carrillo, M. C., Chen, X., Chiba-Falek, O., Davis, A. A., Paolo, G. D., Garretti, F., Gate, D., Golden, L. R., Heinecke, J. W., Herz, J., Huang, Y., Iadecola, C., Johnson, L. A., Kanekiyo, T., Karch, C. M. & Khvorova, A. & 40 others, Koppes-den Hertog, S. J., Lamb, B. T., Lawler, P. E., Guen, Y. L., Litvinchuk, A., Liu, C. C., Mahinrad, S., Marcora, E., Marino, C., Michaelson, D. M., Miller, J. J., Morganti, J. M., Narayan, P. S., Naslavsky, M. S., Oosthoek, M., Ramachandran, K. V., Ramakrishnan, A., Raulin, A. C., Robert, A., Saleh, R. N. M., Sexton, C., Shah, N., Shue, F., Sible, I. J., Soranno, A., Strickland, M. R., Tcw, J., Thierry, M., Tsai, L. H., Tuckey, R. A., Ulrich, J. D., van der Kant, R., Wang, N., Wellington, C. L., Weninger, S. C., Yassine, H. N., Zhao, N., Bu, G., Goate, A. M. & Holtzman, D. M., Sep 2024, In: Alzheimer's and Dementia. 20, 9, p. 6590-6605 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Scopus citations

Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist

Litvinchuk, A., Suh, J. H., Guo, J. L., Lin, K., Davis, S. S., Bien-Ly, N., Tycksen, E., Tabor, G. T., Remolina Serrano, J., Manis, M., Bao, X., Lee, C., Bosch, M., Perez, E. J., Yuede, C. M., Cashikar, A. G., Ulrich, J. D., Di Paolo, G. & Holtzman, D. M., Feb 7 2024, In: Neuron. 112, 3, p. 384-403.e8

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread

Chen, Y., Song, S., Parhizkar, S., Lord, J., Zhu, Y., Strickland, M. R., Wang, C., Park, J., Tabor, G. T., Jiang, H., Li, K., Davis, A. A., Yuede, C. M., Colonna, M., Ulrich, J. D. & Holtzman, D. M., Jan 18 2024, In: Cell. 187, 2, p. 428-445.e20

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Apolipoprotein E secreted by astrocytes forms antiparallel dimers in discoidal lipoproteins

Strickland, M. R., Rau, M. J., Summers, B., Basore, K., Wulf, J., Jiang, H., Chen, Y., Ulrich, J. D., Randolph, G. J., Zhang, R., Fitzpatrick, J. A. J., Cashikar, A. G. & Holtzman, D. M., Apr 3 2024, In: Neuron. 112, 7, p. 1100-1109.e5

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy

Toral-Rios, D., Long, J. M., Ulrich, J. D., Yu, J., Strickland, M. R., Han, X., Holtzman, D. M., Cashikar, A. G. & Paul, S. M., Apr 1 2024, In: Journal of Experimental Medicine. 221, 4, e20232000.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Correction to: Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy (Nature, (2023), 615, 7953, (668-677), 10.1038/s41586-023-05788-0)

Chen, X., Firulyova, M., Manis, M., Herz, J., Smirnov, I., Aladyeva, E., Wang, C., Bao, X., Finn, M. B., Hu, H., Shchukina, I., Kim, M. W., Yuede, C. M., Kipnis, J., Artyomov, M. N., Ulrich, J. D. & Holtzman, D. M., Oct 31 2024, In: Nature. 634, 8036, p. E15

Research output: Contribution to journal › Comment/debate

Open Access

CSF biomarkers of immune activation and Alzheimer’s disease for predicting cognitive impairment risk in the elderly

Shue, F., White, L. J., Hendrix, R. D., Ulrich, J., Henson, R. L., Knight, W., Martens, Y. A., Wang, N., Roy, B., Starling, S. C., Ren, Y., Xiong, C., Asmann, Y. W., Syrjanen, J. A., Vassilaki, M., Mielke, M. M., Timsina, J., Sung, Y. J., Cruchaga, C. & Holtzman, D. M. & 4 others, Bu, G., Petersen, R. C., Heckman, M. G. & Kanekiyo, T., Apr 2024, In: Science Advances. 10, 14, eadk3674.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Erratum: Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist (Neuron (2024) 112(3) (384–403.e8), (S0896627323008048), (10.1016/j.neuron.2023.10.023))

Litvinchuk, A., Suh, J. H., Guo, J. L., Lin, K., Davis, S. S., Bien-Ly, N., Tycksen, E., Tabor, G. T., Serrano, J. R., Manis, M., Bao, X., Lee, C., Bosch, M., Perez, E. J., Yuede, C. M., Cashikar, A. G., Ulrich, J. D., Di Paolo, G. & Holtzman, D. M., Jun 19 2024, In: Neuron. 112, 12, p. 2079 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

Rapid sequential clustering of NMDARs, CaMKII, and AMPARs upon activation of NMDARs at developing synapses

Chen, Y., Liu, S., Jacobi, A. A., Jeng, G., Ulrich, J. D., Stein, I. S., Patriarchi, T. & Hell, J. W., 2024, In: Frontiers in Synaptic Neuroscience. 16, 1291262.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Seq-ing mechanisms behind types of Alzheimer's disease

Chen, Y. & Ulrich, J. D., Jun 5 2024, In: Neuron. 112, 11, p. 1723-1724 2 p.

Research output: Contribution to journal › Comment/debate

2023

ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy

Seo, D. O., O'Donnell, D., Jain, N., Ulrich, J. D., Herz, J., Li, Y., Lemieux, M., Cheng, J., Hu, H., Serrano, J. R., Bao, X., Franke, E., Karlsson, M., Meier, M., Deng, S., Desai, C., Dodiya, H., Lelwala-Guruge, J., Handley, S. A. & Kipnis, J. & 3 others, Sisodia, S. S., Gordon, J. I. & Holtzman, D. M., Jan 13 2023, In: Science. 379, 6628, eadd1236.

Research output: Contribution to journal › Article › peer-review

Open Access

115 Scopus citations

APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading

Wang, C., Nambiar, A., Strickland, M. R., Lee, C., Parhizkar, S., Moore, A. C., Musiek, E. S., Ulrich, J. D. & Holtzman, D. M., Jul 17 2023, In: Journal of Clinical Investigation. 133, 14, e169131.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading

Jain, N., Lewis, C. A., Ulrich, J. D. & Holtzman, D. M., Jan 2 2023, In: Journal of Experimental Medicine. 220, 1, e20220654.

Research output: Contribution to journal › Article › peer-review

Open Access

66 Scopus citations

Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy

Chen, X., Firulyova, M., Manis, M., Herz, J., Smirnov, I., Aladyeva, E., Wang, C., Bao, X., Finn, M. B., Hu, H., Shchukina, I., Kim, M. W., Yuede, C. M., Kipnis, J., Artyomov, M. N., Ulrich, J. D. & Holtzman, D. M., Mar 23 2023, In: Nature. 615, 7953, p. 668-677 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

210 Scopus citations

Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration

Drieu, A., Du, S., Kipnis, M., Bosch, M. E., Herz, J., Lee, C., Jiang, H., Manis, M., Ulrich, J. D., Kipnis, J., Holtzman, D. M. & Gratuze, M., Sep 2023, In: Life Science Alliance. 6, 11, e202302087.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4

Gratuze, M., Schlachetzki, J. C. M., D'Oliveira Albanus, R., Jain, N., Novotny, B., Brase, L., Rodriguez, L., Mansel, C., Kipnis, M., O'Brien, S., Pasillas, M. P., Lee, C., Manis, M., Colonna, M., Harari, O., Glass, C. K., Ulrich, J. D. & Holtzman, D. M., Jan 18 2023, In: Neuron. 111, 2, p. 202-219.e7

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma

Sun, R., Han, R., McCornack, C., Khan, S., Tabor, G. T., Chen, Y., Hou, J., Jiang, H., Schoch, K. M., Mao, D. D., Cleary, R., Yang, A., Liu, Q., Luo, J., Petti, A., Miller, T. M., Ulrich, J. D., Holtzman, D. M. & Kim, A. H., 2023, In: Science Advances. 9, 19, eade3559.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

2022

Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis

Mahan, T. E., Wang, C., Bao, X., Choudhury, A., Ulrich, J. & Holtzman, D. M., Dec 2022, In: Molecular neurodegeneration. 17, 1, 13.

Research output: Contribution to journal › Article › peer-review

Open Access

61 Scopus citations

TREM2 and microglia exosomes: a potential highway for pathological tau

Jain, N. & Ulrich, J. D., Dec 2022, In: Molecular neurodegeneration. 17, 1, 73.

Research output: Contribution to journal › Comment/debate

Open Access

7 Scopus citations

2021

Activated microglia mitigate aβ-associated tau seeding and spreading

Gratuze, M., Chen, Y., Parhizkar, S., Jain, N., Strickland, M. R., Serrano, J. R., Colonna, M., Ulrich, J. D. & Holtzman, D. M., Aug 2 2021, In: Journal of Experimental Medicine. 218, 8, e20210542.

Research output: Contribution to journal › Article › peer-review

Open Access

106 Scopus citations

A New Understanding of Alzheimer's

Ulrich, J. & Holtzman, D. M., Aug 1 2021, In: Scientific American. 325, 2, p. 38 1 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function

Xiong, M., Jiang, H., Serrano, J. R., Gonzales, E. R., Wang, C., Gratuze, M., Hoyle, R., Bien-Ly, N., Silverman, A. P., Sullivan, P. M., Watts, R. J., Ulrich, J. D., Zipfel, G. J. & Holtzman, D. M., Feb 17 2021, In: Science translational medicine. 13, 581, eabd7522.

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model

Litvinchuk, A., Huynh, T. P. V., Shi, Y., Jackson, R. J., Finn, M. B., Manis, M., Francis, C. M., Tran, A. C., Sullivan, P. M., Ulrich, J. D., Hyman, B. T., Cole, T. & Holtzman, D. M., May 2021, In: Annals of neurology. 89, 5, p. 952-966 15 p.

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation

Lall, D., Lorenzini, I., Mota, T. A., Bell, S., Mahan, T. E., Ulrich, J. D., Davtyan, H., Rexach, J. E., Muhammad, A. K. M. G., Shelest, O., Landeros, J., Vazquez, M., Kim, J., Ghaffari, L., O'Rourke, J. G., Geschwind, D. H., Blurton-Jones, M., Holtzman, D. M., Sattler, R. & Baloh, R. H., Jul 21 2021, In: Neuron. 109, 14, p. 2275-2291.e8

Research output: Contribution to journal › Article › peer-review

Open Access

84 Scopus citations

Neuronal VCP loss of function recapitulates FTLD-TDP pathology

Wani, A., Zhu, J., Ulrich, J. D., Eteleeb, A., Sauerbeck, A. D., Reitz, S. J., Arhzaouy, K., Ikenaga, C., Yuede, C. M., Pittman, S. K., Wang, F., Li, S., Benitez, B. A., Cruchaga, C., Kummer, T. T., Harari, O., Chou, T. F., Schröder, R., Clemen, C. S. & Weihl, C. C., Jul 20 2021, In: Cell Reports. 36, 3, 109399.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms

Shi, Y., Andhey, P. S., Ising, C., Wang, K., Snipes, L. L., Boyer, K., Lawson, S., Yamada, K., Qin, W., Manis, M., Serrano, J. R., Benitez, B. A., Schmidt, R. E., Artyomov, M., Ulrich, J. D. & Holtzman, D. M., Aug 4 2021, In: Neuron. 109, 15, p. 2413-2426.e7

Research output: Contribution to journal › Article › peer-review

Open Access

73 Scopus citations

Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia

Wang, C., Xiong, M., Gratuze, M., Bao, X., Shi, Y., Andhey, P. S., Manis, M., Schroeder, C., Yin, Z., Madore, C., Butovsky, O., Artyomov, M., Ulrich, J. D. & Holtzman, D. M., May 19 2021, In: Neuron. 109, 10, p. 1657-1674.e7

Research output: Contribution to journal › Article › peer-review

Open Access

170 Scopus citations

2020

APOE genotype regulates pathology and disease progression in synucleinopathy

Davis, A. A., Inman, C. E., Wargel, Z. M., Dube, U., Freeberg, B. M., Galluppi, A., Haines, J. N., Dhavale, D. D., Miller, R., Choudhury, F. A., Sullivan, P. M., Cruchaga, C., Perlmutter, J. S., Ulrich, J. D., Benitez, B. A., Kotzbauer, P. T. & Holtzman, D. M., Feb 5 2020, In: Science translational medicine. 12, 529, eaay3069.

Research output: Contribution to journal › Article › peer-review

Open Access

108 Scopus citations

Author Correction: Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease (Nature Medicine, (2020), 26, 1, (131-142), 10.1038/s41591-019-0695-9)

Zhou, Y., Song, W. M., Andhey, P. S., Swain, A., Levy, T., Miller, K. R., Poliani, P. L., Cominelli, M., Grover, S., Gilfillan, S., Cella, M., Ulland, T. K., Zaitsev, K., Miyashita, A., Ikeuchi, T., Sainouchi, M., Kakita, A., Bennett, D. A., Schneider, J. A. & Nichols, M. R. & 5 others, Beausoleil, S. A., Ulrich, J. D., Holtzman, D. M., Artyomov, M. N. & Colonna, M., Jun 1 2020, In: Nature medicine. 26, 6, p. 981 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

5 Scopus citations

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

Zhou, Y., Song, W. M., Andhey, P. S., Swain, A., Levy, T., Miller, K. R., Poliani, P. L., Cominelli, M., Grover, S., Gilfillan, S., Cella, M., Ulland, T. K., Zaitsev, K., Miyashita, A., Ikeuchi, T., Sainouchi, M., Kakita, A., Bennett, D. A., Schneider, J. A. & Nichols, M. R. & 5 others, Beausoleil, S. A., Ulrich, J. D., Holtzman, D. M., Artyomov, M. N. & Colonna, M., Jan 1 2020, In: Nature medicine. 26, 1, p. 131-142 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

614 Scopus citations

Impact of TREM2^R47Hvariant on tau pathology-induced gliosis and neurodegeneration

Gratuze, M., Leyns, C. E. G., Sauerbeck, A. D., St-Pierre, M. K., Xiong, M., Kim, N., Serrano, J. R., Tremblay, M. È., Kummer, T. T., Colonna, M., Ulrich, J. D. & Holtzman, D. M., Sep 1 2020, In: Journal of Clinical Investigation. 130, 9, p. 4954-4968 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

131 Scopus citations

2019

Lack of hepatic apoE does not influence early Aβ deposition: Observations from a new APOE knock-in model

Huynh, T. P. V., Wang, C., Tran, A. C., Tabor, G. T., Mahan, T. E., Francis, C. M., Finn, M. B., Spellman, R., Manis, M., Tanzi, R. E., Ulrich, J. D. & Holtzman, D. M., Oct 17 2019, In: Molecular neurodegeneration. 14, 1, 37.

Research output: Contribution to journal › Article › peer-review

Open Access

87 Scopus citations

Senescent glia spell trouble in Alzheimer’s disease

Holtzman, D. & Ulrich, J., May 1 2019, In: Nature neuroscience. 22, 5, p. 683-684 2 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

TREM2 function impedes tau seeding in neuritic plaques

Leyns, C. E. G., Gratuze, M., Narasimhan, S., Jain, N., Koscal, L. J., Jiang, H., Manis, M., Colonna, M., Lee, V. M. Y., Ulrich, J. D. & Holtzman, D. M., Aug 1 2019, In: Nature neuroscience. 22, 8, p. 1217-1222 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

187 Scopus citations

2018

ApoE facilitates the microglial response to amyloid plaque pathology

Ulrich, J. D., Ulland, T. K., Mahan, T. E., Nyström, S., Peter Nilsson, K., Song, W. M., Zhou, Y., Reinartz, M., Choi, S., Jiang, H., Stewart, F. R., Anderson, E., Wang, Y., Colonna, M. & Holtzman, D. M., Apr 1 2018, In: Journal of Experimental Medicine. 215, 4, p. 1047-1058 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

191 Scopus citations

Behavioral and transcriptomic analysis of Trem2-null mice: Not all knockout mice are created equal

Kang, S. S., Kurti, A., Baker, K. E., Liu, C. C., Colonna, M., Ulrich, J. D., Holtzman, D. M., Bu, G. & Fryer, J. D., Jan 15 2018, In: Human molecular genetics. 27, 2, p. 211-223 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

High-affinity interactions and signal transduction between Aβ oligomers and TREM2

Lessard, C. B., Malnik, S. L., Zhou, Y., Ladd, T. B., Cruz, P. E., Ran, Y., Mahan, T. E., Chakrabaty, P., Holtzman, D. M., Ulrich, J. D., Colonna, M. & Golde, T. E., Nov 2018, In: EMBO Molecular Medicine. 10, 11, e9027.

Research output: Contribution to journal › Article › peer-review

Open Access

89 Scopus citations

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

Liao, F., Li, A., Xiong, M., Bien-Ly, N., Jiang, H., Zhang, Y., Finn, M. B., Hoyle, R., Keyser, J., Lefton, K. B., Robinson, G. O., Serrano, J. R., Silverman, A. P., Guo, J. L., Getz, J., Henne, K., Leyns, C. E. G., Gallardo, G., Ulrich, J. D. & Sullivan, P. M. & 7 others, Lerner, E. P., Hudry, E., Sweeney, Z. K., Dennis, M. S., Hyman, B. T., Watts, R. J. & Holtzman, D. M., May 1 2018, In: Journal of Clinical Investigation. 128, 5, p. 2144-2155 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

120 Scopus citations

2017

Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis

Huynh, T. P. V., Liao, F., Francis, C. M., Robinson, G. O., Serrano, J. R., Jiang, H., Roh, J., Finn, M. B., Sullivan, P. M., Esparza, T. J., Stewart, F. R., Mahan, T. E., Ulrich, J. D., Cole, T. & Holtzman, D. M., Dec 6 2017, In: Neuron. 96, 5, p. 1013-1023.e4

Research output: Contribution to journal › Article › peer-review

Open Access

149 Scopus citations

Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy

Yanamandra, K., Patel, T. K., Jiang, H., Schindler, S., Ulrich, J. D., Boxer, A. L., Miller, B. L., Kerwin, D. R., Gallardo, G., Stewart, F., Finn, M. B., Cairns, N. J., Verghese, P. B., Fogelman, I., West, T., Braunstein, J., Robinson, G., Keyser, J., Roh, J. & Knapik, S. S. & 2 others, Hu, Y. & Holtzman, D. M., Apr 19 2017, In: Science translational medicine. 9, 386, eaal2029.

Research output: Contribution to journal › Article › peer-review

Open Access

78 Scopus citations

Apolipoprotein E and Alzheimer's disease: The influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins

Huynh, T. P. V., Davis, A. A., Ulrich, J. D. & Holtzman, D. M., May 2017, In: Journal of lipid research. 58, 5, p. 824-836 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

151 Scopus citations

Elucidating the Role of TREM2 in Alzheimer's Disease

Ulrich, J. D., Ulland, T. K., Colonna, M. & Holtzman, D. M., Apr 19 2017, In: Neuron. 94, 2, p. 237-248 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

246 Scopus citations

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Krasemann, S., Madore, C., Cialic, R., Baufeld, C., Calcagno, N., El Fatimy, R., Beckers, L., O'Loughlin, E., Xu, Y., Fanek, Z., Greco, D. J., Smith, S. T., Tweet, G., Humulock, Z., Zrzavy, T., Conde-Sanroman, P., Gacias, M., Weng, Z., Chen, H. & Tjon, E. & 18 others, Mazaheri, F., Hartmann, K., Madi, A., Ulrich, J. D., Glatzel, M., Worthmann, A., Heeren, J., Budnik, B., Lemere, C., Ikezu, T., Heppner, F. L., Litvak, V., Holtzman, D. M., Lassmann, H., Weiner, H. L., Ochando, J., Haass, C. & Butovsky, O., Sep 19 2017, In: Immunity. 47, 3, p. 566-581.e9

Research output: Contribution to journal › Article › peer-review

Open Access

1682 Scopus citations

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

Leyns, C. E. G., Ulrich, J. D., Finn, M. B., Stewart, F. R., Koscal, L. J., Serrano, J. R., Robinson, G. O., Anderson, E., Colonna, M. & Holtzman, D. M., Oct 24 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 43, p. 11524-11529 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

318 Scopus citations

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease

Ulland, T. K., Song, W. M., Huang, S. C. C., Ulrich, J. D., Sergushichev, A., Beatty, W. L., Loboda, A. A., Zhou, Y., Cairns, N. J., Kambal, A., Loginicheva, E., Gilfillan, S., Cella, M., Virgin, H. W., Unanue, E. R., Wang, Y., Artyomov, M. N., Holtzman, D. M. & Colonna, M., Aug 10 2017, In: Cell. 170, 4, p. 649-663.e13

Research output: Contribution to journal › Article › peer-review

Open Access

778 Scopus citations

2016

Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes

Chung, W. S., Verghese, P. B., Chakraborty, C., Joung, J., Hyman, B. T., Ulrich, J. D., Holtzman, D. M. & Barres, B. A., Sep 6 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 36, p. 10186-10191 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

166 Scopus citations

TREM2 Function in Alzheimer's Disease and Neurodegeneration

Ulrich, J. D. & Holtzman, D. M., Apr 20 2016, In: ACS Chemical Neuroscience. 7, 4, p. 420-427 8 p.

Research output: Contribution to journal › Review article › peer-review

103 Scopus citations

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

Wang, Y., Ulland, T. K., Ulrich, J. D., Song, W., Tzaferis, J. A., Hole, J. T., Yuan, P., Mahan, T. E., Shi, Y., Gilfillan, S., Cella, M., Grutzendler, J., DeMattos, R. B., Cirrito, J. R., Holtzman, D. M. & Colonna, M., May 2 2016, In: Journal of Experimental Medicine. 213, 5, p. 667-675 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

559 Scopus citations

2015

Re-evaluation of the Blood-Brain Barrier in the Presence of Alzheimer's Disease Pathology

Ulrich, J. D., Huynh, T. P. & Holtzman, D. M., Oct 21 2015, In: Neuron. 88, 2, p. 237-239 3 p.

Research output: Contribution to journal › Short survey › peer-review

Open Access

16 Scopus citations

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

Wang, Y., Cella, M., Mallinson, K., Ulrich, J. D., Young, K. L., Robinette, M. L., Gilfillan, S., Krishnan, G. M., Sudhakar, S., Zinselmeyer, B. H., Holtzman, D. M., Cirrito, J. R. & Colonna, M., Mar 15 2015, In: Cell. 160, 6, p. 1061-1071 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1207 Scopus citations

Jason Ulrich

Research output

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