Research Output per year
Research Output per year
Personal profile
Research interests
We study how the stem cells of the upper gastrointestinal tract give rise to mature cell lineage. In particular, we are interested in the zymogenic (chief) cell lineage in the body of the stomach, as we think these cells are susceptible to aberrant differentiation in the setting of chronic inflammation. This aberrant differentiation (metaplasia) is a precursor for gastric cancer. We study the genetic regulation of zymogenic cell differentiation in disease and in normal gastric units and also are quite interested in how the stem cell differentiates into the zymogenic precursor cell, the mucous neck cell.
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Research Output
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DDIT4 Licenses Only Healthy Cells to Proliferate During Injury-induced Metaplasia
Miao, Z. F., Sun, J. X., Adkins-Threats, M., Pang, M. J., Zhao, J. H., Wang, X., Tang, K. W., Wang, Z. N. & Mills, J. C., Jan 2021, In: Gastroenterology. 160, 1, p. 260-271.e10Research output: Contribution to journal › Article › peer-review
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A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
Miao, Z. F., Lewis, M. A., Cho, C. J., Adkins-Threats, M., Park, D., Brown, J. W., Sun, J. X., Burclaff, J. R., Kennedy, S., Lu, J., Mahar, M., Vietor, I., Huber, L. A., Davidson, N. O., Cavalli, V., Rubin, D. C., Wang, Z. N. & Mills, J. C., Oct 26 2020, In: Developmental cell. 55, 2, p. 178-194.e7Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation
Miao, Z. F., Adkins-Threats, M., Burclaff, J. R., Osaki, L. H., Sun, J. X., Kefalov, Y., He, Z., Wang, Z. N. & Mills, J. C., Jun 4 2020, In: Cell Stem Cell. 26, 6, p. 910-925.e6Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
A new approach for filtering noise from high-density oligonucleotide microarray datasets
Mills, J. C. & Gordon, J. I., 2020, In: Nucleic acids research. 29, 15, e72.Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
Autophagy repurposes cells during paligenosis
Miao, Z. F., Cho, C. J., Wang, Z. N. & Mills, J. C., 2020, (Accepted/In press) In: Autophagy.Research output: Contribution to journal › Article › peer-review