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Jason Mills

Professor of Medicine, Professor of Developmental Biology, Professor of Pathology and Immunology

    • 6446 Citations
    1993 …2020

    Research output per year

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    Personal profile

    Research interests

    We study how the stem cells of the upper gastrointestinal tract give rise to mature cell lineage. In particular, we are interested in the zymogenic (chief) cell lineage in the body of the stomach, as we think these cells are susceptible to aberrant differentiation in the setting of chronic inflammation. This aberrant differentiation (metaplasia) is a precursor for gastric cancer. We study the genetic regulation of zymogenic cell differentiation in disease and in normal gastric units and also are quite interested in how the stem cell differentiates into the zymogenic precursor cell, the mucous neck cell.

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    Research Output

    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle

    Miao, Z. F., Lewis, M. A., Cho, C. J., Adkins-Threats, M., Park, D., Brown, J. W., Sun, J. X., Burclaff, J. R., Kennedy, S., Lu, J., Mahar, M., Vietor, I., Huber, L. A., Davidson, N. O., Cavalli, V., Rubin, D. C., Wang, Z. N. & Mills, J. C., 2020, (Accepted/In press) In : Developmental cell.

    Research output: Contribution to journal › Article

    • A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation

    Miao, Z. F., Adkins-Threats, M., Burclaff, J. R., Osaki, L. H., Sun, J. X., Kefalov, Y., He, Z., Wang, Z. N. & Mills, J. C., Jun 4 2020, In : Cell Stem Cell. 26, 6, p. 910-925.e6

    Research output: Contribution to journal › Article

    • 2 Scopus citations

    Helicobacter pylori: Preying on SIVA for survival in the stomach

    Sáenz, J. B. & Mills, J. C., May 1 2020, In : Journal of Clinical Investigation. 130, 5, p. 2183-2185 3 p.

    Research output: Contribution to journal › Review article

    • Interleukin 27 Protects From Gastric Atrophy and Metaplasia During Chronic Autoimmune Gastritis

    Bockerstett, K. A., Petersen, C. P., Noto, C. N., Kuehm, L. M., Wong, C. F., Ford, E. L., Teague, R. M., Mills, J. C., Goldenring, J. R. & DiPaolo, R. J., 2020, In : CMGH. 10, 3, p. 561-579 19 p.

    Research output: Contribution to journal › Article

    Open Access

    • Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis

    Jackson, D. N., Panopoulos, M., Neumann, W. L., Turner, K., Cantarel, B. L., Thompson-Snipes, L., Dassopoulos, T., Feagins, L. A., Souza, R. F., Mills, J. C., Blumberg, R. S., Venuprasad, K., Thompson, W. E. & Theiss, A. L., Jan 1 2020, (Accepted/In press) In : Gut.

    Research output: Contribution to journal › Article

    Open Access
    • 3 Scopus citations