Research output per year
Research output per year
Personal profile
Research interests
We study how the stem cells of the upper gastrointestinal tract give rise to mature cell lineage. In particular, we are interested in the zymogenic (chief) cell lineage in the body of the stomach, as we think these cells are susceptible to aberrant differentiation in the setting of chronic inflammation. This aberrant differentiation (metaplasia) is a precursor for gastric cancer. We study the genetic regulation of zymogenic cell differentiation in disease and in normal gastric units and also are quite interested in how the stem cell differentiates into the zymogenic precursor cell, the mucous neck cell.
Fingerprint
Dive into the research topics where Jason Mills is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 7 Similar Profiles
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer
Blanc, V., Riordan, J. D., Soleymanjahi, S., Nadeau, J. H., Nalbantoglu, ILK., Xie, Y., Molitor, E. A., Madison, B. B., Brunt, E. M., Mills, J. C., Rubin, D. C., Ng, I. O., Ha, Y., Roberts, L. R. & Davidson, N. O., Jan 4 2021, In: Journal of Clinical Investigation. 131, 1, e138699.Research output: Contribution to journal › Article › peer-review
Open Access -
Autophagy repurposes cells during paligenosis
Miao, Z. F., Cho, C. J., Wang, Z. N. & Mills, J. C., 2021, In: Autophagy. 17, 2, p. 588-589 2 p.Research output: Contribution to journal › Article › peer-review
-
Cellular plasticity at the nexus of development and disease
Spatz, L. B., Jin, R. U. & Mills, J. C., Feb 2021, In: Development (Cambridge). 148, 3, dev197392.Research output: Contribution to journal › Review article › peer-review
Open Access -
DDIT4 Licenses Only Healthy Cells to Proliferate During Injury-induced Metaplasia
Miao, Z. F., Sun, J. X., Adkins-Threats, M., Pang, M. J., Zhao, J. H., Wang, X., Tang, K. W., Wang, Z. N. & Mills, J. C., Jan 2021, In: Gastroenterology. 160, 1, p. 260-271.e10Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Interleukin 33 Triggers Early Eosinophil-Dependent Events Leading to Metaplasia in a Chronic Model of Gastritis-Prone Mice
De Salvo, C., Pastorelli, L., Petersen, C. P., Buttò, L. F., Buela, K. A., Omenetti, S., Locovei, S. A., Ray, S., Friedman, H. R., Duijser, J., Xin, W., Osme, A., Cominelli, F., Mahabeleshwar, G. H., Mills, J. C., Goldenring, J. R. & Pizarro, T. T., Jan 2021, In: Gastroenterology. 160, 1, p. 302-316.e7Research output: Contribution to journal › Article › peer-review
3 Scopus citations