Jason Hassenstab

2025

Associations of Cerebrospinal Fluid Orexin-A, Alzheimer Disease Biomarkers, and Cognitive Performance

Lu, R., Shah, K., Toedebusch, C. D., Hess, A., Richardson, R., Mignot, E., Schindler, S., Benzinger, T. L. S., Flores, S., Hassenstab, J., Xiong, C., Morris, J., Holtzman, D. & Lucey, B. P., 2025, (Accepted/In press) In: Annals of Clinical and Translational Neurology.

Research output: Contribution to journal › Article › peer-review

Open Access

Mayo Normative Studies: regression-based normative data for remote self-administration of the Stricker Learning Span, Symbols Test, and Mayo Test Drive Screening Battery Composite and validation in individuals with mild cognitive impairment and dementia

Stricker, N. H., Frank, R. D., Boots, E. A., Fan, W. Z., Christianson, T. J., Kremers, W. K., Stricker, J. L., Machulda, M. M., Fields, J. A., Lucas, J. A., Hassenstab, J., Aduen, P. A., Day, G., Graff-Radford, N. R., Jack, C. R., Graff-Radford, J. & Petersen, R. C., 2025, (Accepted/In press) In: Clinical Neuropsychologist.

Research output: Contribution to journal › Article › peer-review

Open Access

Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial

Dominantly Inherited Alzheimer's Disease–Trials Unit, Apr 2025, In: The Lancet Neurology. 24, 4, p. 316-330 15 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Usability of the Mayo Test Drive remote self-administered web-based cognitive screening battery in adults aged 35–100 with and without cognitive impairment

Patel, J. S., Christianson, T. J., Monahan, L. T., Frank, R. D., Fan, W. Z., Stricker, J. L., Kremers, W. K., Karstens, A. J., Machulda, M. M., Fields, J. A., Hassenstab, J., Jack, C. R., Botha, H., Graff-Radford, J., Petersen, R. C. & Stricker, N. H., 2025, In: Journal of Clinical and Experimental Neuropsychology. 47, 1-2, p. 67-89 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2024

Adapting prescribing criteria for amyloid-targeted antibodies for adults with Down syndrome

Hillerstrom, H., Fisher, R., Janicki, M. P., Chicoine, B., Christian, B. T., Esbensen, A., Esralew, L., Fortea, J., Hartley, S., Hassenstab, J., Keller, S. M., Krinsky-McHale, S., Lai, F., Levin, J., McCarron, M., McDade, E., Rebillat, A. S., Rosas, H. D., Silverman, W. & Strydom, A. & 2 others, Zaman, S. H. & Zetterberg, H., May 2024, In: Alzheimer's and Dementia. 20, 5, p. 3649-3656 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome

Gorijala, P., Aslam, M. M., Dang, L. H. T., Xicota, L., Fernandez, M. V., Sung, Y. J., Fan, K. H., Feingold, E., Surace, E. I., Chhatwal, J. P., Hom, C. L., Hartley, S. L., Hassenstab, J., Perrin, R. J., Mapstone, M., Zaman, S. H., Ances, B. M., Kamboh, M. I., Lee, J. H. & Cruchaga, C., Feb 2024, In: Alzheimer's and Dementia. 20, 2, p. 1038-1049 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Antecedents of Mind Wandering States in Healthy Aging and Mild Cognitive Impairment

Aschenbrenner, A. J., Welhaf, M. S., Hassenstab, J. J. & Jackson, J. J., Feb 8 2024, In: Neuropsychology. 38, 5, p. 430-442 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease

Son, H. J., Kim, J. S., Bateman, R. J., Kim, S., Llibre-Guerra, J. J., Day, G. S., Chhatwal, J. P., Berman, S. B., Schofield, P. R., Jucker, M., Levin, J., Lee, J. H., Perrin, R. J., Morris, J. C., Cruchaga, C., Hassenstab, J., Salloway, S. P., Lee, J. H. & Daniels, A., Sep 13 2024, In: Neurology. 103, 7

Research output: Contribution to journal › Article › peer-review

Open Access

Axonal damage and inflammation response are biological correlates of decline in small-world values: a cohort study in autosomal dominant Alzheimer’s disease

on behalf of the Dominantly Inherited Alzheimer Network, 2024, In: Brain Communications. 6, 5, fcae357.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease

Dominantly Inherited Alzheimer Network, Dec 2024, In: Nature communications. 15, 1, 9982.

Research output: Contribution to journal › Article › peer-review

Open Access

Comparison of cerebrospinal fluid, plasma and neuroimaging biomarker utility in Alzheimer’s disease

Meeker, K. L., Luckett, P. H., Barthélemy, N. R., Hobbs, D. A., Chen, C., Bollinger, J., Ovod, V., Flores, S., Keefe, S., Henson, R. L., Herries, E. M., McDade, E., Hassenstab, J. J., Xiong, C., Cruchaga, C., Benzinger, T. L. S., Holtzman, D. M., Schindler, S. E., Bateman, R. J. & Morris, J. C. & 2 others, Gordon, B. A. & Ances, B. M., 2024, In: Brain Communications. 6, 2

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study

Alzheimer's Biomarker Consortium–Down Syndrome, Dominantly Inherited Alzheimer Network, Wisch, J. K., McKay, N. S., Boerwinkle, A. H., Kennedy, J., Flores, S., Handen, B. L., Christian, B. T., Head, E., Mapstone, M., Rafii, M. S., O'Bryant, S. E., Price, J. C., Laymon, C. M., Krinsky-McHale, S. J., Lai, F., Rosas, H. D., Hartley, S. L. & Zaman, S. & 152 others, Lott, I. T., Tudorascu, D., Zammit, M., Brickman, A. M., Lee, J. H., Bird, T. D., Cohen, A., Chrem, P., Daniels, A., Chhatwal, J. P., Cruchaga, C., Ibanez, L., Jucker, M., Karch, C. M., Day, G. S., Lee, J. H., Levin, J., Llibre-Guerra, J., Li, Y., Lopera, F., Roh, J. H., Ringman, J. M., Supnet-Bell, C., van Dyck, C. H., Xiong, C., Wang, G., Morris, J. C., McDade, E., Bateman, R. J., Benzinger, T. L. S., Gordon, B. A., Ances, B. M., Aizenstein, H. J., Andrews, H. F., Bell, K., Birn, R. M., Bulova, P., Cheema, A., Chen, K., Clare, I., Clark, L., Cohen, A. D., Constantino, J. N., Doran, E. W., Feingold, E., Foroud, T. M., Hartley, S. L., Hom, C., Honig, L., Ikonomovic, M. D., Johnson, S. C., Jordan, C., Kamboh, M. I., Keator, D., Klunk, W. E., Kofler, J. K., Kreisl, W. C., Krinsky-McHale, S. J., Lao, P., Laymon, C., Lott, I. T., Lupson, V., Mathis, C. A., Minhas, D. S., Nadkarni, N., Pang, D., Petersen, M., Price, J. C., Pulsifer, M., Reiman, E., Rizvi, B., Sabbagh, M. N., Schupf, N., Tudorascu, D. L., Tumuluru, R., Tycko, B., Varadarajan, B., White, D. A., Yassa, M. A., Zhang, F., Bateman, R., Daniels, A., Courtney, L., Llibre-Guerra, J., Xiong, C., Xu, X., Lu, R., Gremminger, E., Perrin, R. J., Franklin, E., Jerome, G., Herries, E., Stauber, J., Baker, B., Minton, M., Goate, A. M., Renton, A. E., Picarello, D. M., Benzinger, T., Gordon, B. A., Hornbeck, R., Hassenstab, J., Smith, J., Stout, S., Aschenbrenner, A. J., Karch, C. M., Marsh, J., Morris, J. C., Holtzman, D. M., Barthelemy, N., Xu, J., Noble, J. M., Berman, S. B., Ikonomovic, S., Nadkarni, N. K., Day, G., Graff-Radford, N. R., Farlow, M., Chhatwal, J. P., Ikeuchi, T., Kasuga, K., Niimi, Y., Huey, E. D., Salloway, S., Schofield, P. R., Brooks, W. S., Bechara, J. A., Martins, R., Fox, N. C., Cash, D. M., Ryan, N. S., Laske, C., Hofmann, A., Kuder-Buletta, E., Graber-Sultan, S., Obermueller, U., Roedenbeck, Y., Vöglein, J., Sanchez-Valle, R., Rosa-Neto, P., Allegri, R. F., Chrem Mendez, P., Surace, E., Vazquez, S., Leon, Y. M., Ramirez, L., Aguillon, D., Levey, A. I., Johnson, E. C. B., Seyfried, N. T., Ringman, J. & Mori, H., May 2024, In: The Lancet Neurology. 23, 5, p. 500-510 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Continuous Associations between Remote Self-Administered Cognitive Measures and Imaging Biomarkers of Alzheimer’s Disease

Boots, E. A., Frank, R. D., Fan, W. Z., Christianson, T. J., Kremers, W. K., Stricker, J. L., Machulda, M. M., Fields, J. A., Hassenstab, J., Graff-Radford, J., Vemuri, P., Jack, C. R., Knopman, D. S., Petersen, R. C. & Stricker, N. H., Oct 2024, In: The journal of prevention of Alzheimer's disease. 11, 5, p. 1467-1479 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Cross-Sectional and Longitudinal Changes in Mind-Wandering in Older Adulthood

Welhaf, M. S., Balota, D. A., Morris, J. C., Hassenstab, J. & Aschenbrenner, A. J., 2024, In: Psychology and Aging. 39, 5, p. 495-509 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

CSF proteomics identifies early changes in autosomal dominant Alzheimer's disease

Dominantly Inherited Alzheimer Network, Oct 31 2024, In: Cell. 187, 22, p. 6309-6326.e15

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging

the Dominantly Inherited Alzheimer Network (DIAN) Investigators, Doering, S., McCullough, A., Gordon, B. A., Chen, C. D., McKay, N., Hobbs, D., Keefe, S., Flores, S., Scott, J., Smith, H., Jarman, S., Jackson, K., Hornbeck, R. C., Ances, B. M., Xiong, C., Aschenbrenner, A. J., Hassenstab, J., Cruchaga, C. & Daniels, A. & 104 others, Bateman, R. J., Noble, J. M., Day, G. S., Graff-Radford, N. R., Voglein, J., Levin, J., Allegri, R. F., Mendez, P. C., Surace, E., Berman, S. B., Ikonomovic, S., Nadkarni, N. K., Lopera, F., Ramirez, L., Aguillon, D., Leon, Y., Ramos, C., Alzate, D., Baena, A., Londono, N., Moreno, S., Jucker, M., Laske, C., Kuder-Buletta, E., Graber-Sultan, S., Preische, O., Hofmann, A., Ikeuchi, T., Kasuga, K., Niimi, Y., Ishii, K., Senda, M., Sanchez-Valle, R., Rosa-Neto, P., Fox, N. C., Cash, D., Lee, J. H., Roh, J. H., Salloway, S., Riddle, M. C., Menard, W., Bodge, C., Surti, M., Takada, L. T., Farlow, M., Chhatwal, J. P., Sanchez-Gonzalez, V. J., Orozco-Barajas, M., Goate, A. M., Renton, A. E., Esposito, B. T., Karch, C. M., Marsh, J., Fernanadez, V., Fagan, A. M., Jerome, G., Herries, E., Llibre-Guerra, J., Levey, A. I., Johnson, E. C. B., Seyfried, N. T., Schofield, P. R., Brooks, W. S., Bechara, J. A., Bateman, R., McDade, E., Perrin, R. J., Franklin, E. E., Benzinger, T., Chen, A., Chen, C., Friedrichsen, N., Gordon, B., Hantler, N., Hornbeck, R., Jarman, S., Koudelis, D., Massoumzadeh, P., Nicklaus, J., Pulizos, C., Wang, Q., Mishall, S., Sabaredzovic, E., Deng, E., Candela, M., Wang, P., Xu, X., Li, Y., Gremminger, E., Ma, Y., Bui, R., Lu, R., Martins, R., Sosa Ortiz, A. L., Courtney, L., Mori, H., Supnet-Bell, C., Xu, J., Ringman, J., Barthelemy, N., Morris, J., Smith, J., Morris, J. C. & Benzinger, T. L. S., May 2024, In: EBioMedicine. 103, 105080.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial

Wagemann, O., Liu, H., Wang, G., Shi, X., Bittner, T., Scelsi, M. A., Farlow, M. R., Clifford, D. B., Supnet-Bell, C., Santacruz, A. M., Aschenbrenner, A. J., Hassenstab, J. J., Benzinger, T. L. S., Gordon, B. A., Coalier, K. A., Cruchaga, C., Ibanez, L., Perrin, R. J., Xiong, C. & Li, Y. & 30 others, Morris, J. C., Lah, J. J., Berman, S. B., Roberson, E. D., Van Dyck, C. H., Galasko, D., Gauthier, S., Hsiung, G. Y. R., Brooks, W. S., Pariente, J., Mummery, C. J., Day, G. S., Ringman, J. M., Mendez, P. C., St. George-Hyslop, P., Fox, N. C., Suzuki, K., Okhravi, H. R., Chhatwal, J., Levin, J., Jucker, M., Sims, J. R., Holdridge, K. C., Proctor, N. K., Yaari, R., Andersen, S. W., Mancini, M., Llibre-Guerra, J., Bateman, R. J. & McDade, E., Jun 10 2024, In: JAMA Neurology. 81, 6, p. 582-593 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer's disease

Wang, G., Li, Y., Xiong, C., Benzinger, T. L. S., Gordon, B. A., Hassenstab, J., Aschenbrenner, A. J., McDade, E., Clifford, D. B., Libre-Guerra, J. J., Shi, X., Mummery, C. J., van Dyck, C. H., Lah, J. J., Honig, L. S., Day, G., Ringman, J. M., Brooks, W. S., Fox, N. C. & Suzuki, K. & 5 others, Levin, J., Jucker, M., Delmar, P., Bittner, T. & Bateman, R. J., Apr 2024, In: Alzheimer's and Dementia. 20, 4, p. 2698-2706 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Free Recall Outperforms Story Recall in Associations with Plasma Biomarkers in Preclinical Alzheimer Disease

Aschenbrenner, A., Hassenstab, J. J., Schindler, S. E., Janelidze, S., Hansson, O., Morris, J. C. & Grober, E., Dec 2024, In: The journal of prevention of Alzheimer's disease. 11, 6, p. 1696-1702 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center

Fernandez, M. V., Liu, M., Beric, A., Johnson, M., Cetin, A., Patel, M., Budde, J., Kohlfeld, P., Bergmann, K., Lowery, J., Flynn, A., Brock, W., Sanchez Montejo, B., Gentsch, J., Sykora, N., Norton, J., Gentsch, J., Valdez, O., Gorijala, P. & Sanford, J. & 24 others, Sun, Y., Wang, C., Western, D., Timsina, J., Mangetti Goncalves, T., Do, A. N., Sung, Y. J., Zhao, G., Morris, J. C., Moulder, K., Holtzman, D. M., Bateman, R. J., Karch, C., Hassenstab, J., Xiong, C., Schindler, S. E., Balls-Berry, J., Benzinger, T. L. S., Perrin, R. J., Denny, A., Snider, B. J., Stark, S. L., Ibanez, L. & Cruchaga, C., Dec 2024, In: Scientific data. 11, 1, 768.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Investigating White Matter Neuroinflammation in Alzheimer Disease Using Diffusion-Based Neuroinflammation Imaging

Wang, Q., Schindler, S. E., Chen, G., Mckay, N. S., McCullough, A., Flores, S., Liu, J., Sun, Z., Wang, S., Wang, W., Hassenstab, J., Cruchaga, C., Perrin, R. J., Niven, A., Morris, J. C., Wang, Y. & Benzinger, T. L. S., Feb 5 2024, In: Neurology. 102, 4, e208013.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Investigation of sex differences in mutation carriers of the Dominantly Inherited Alzheimer Network

Wagemann, O., Li, Y., Hassenstab, J., Aschenbrenner, A. J., McKay, N. S., Gordon, B. A., Benzinger, T. L. S., Xiong, C., Cruchaga, C., Renton, A. E., Perrin, R. J., Berman, S. B., Chhatwal, J. P., Farlow, M. R., Day, G. S., Ikeuchi, T., Jucker, M., Lopera, F., Mori, H. & Noble, J. M. & 8 others, Sánchez-Valle, R., Schofield, P. R., Morris, J. C., Daniels, A., Levin, J., Bateman, R. J., McDade, E. & Llibre-Guerra, J. J., Jan 2024, In: Alzheimer's and Dementia. 20, 1, p. 47-62 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Longitudinal associations between exercise and biomarkers in autosomal dominant Alzheimer's disease

The Dominantly Inherited Alzheimer's Network, Nov 2024, In: Alzheimer's and Dementia. 20, 11, p. 7923-7939 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Molecular neuroimaging in dominantly inherited versus sporadic early-onset Alzheimer's disease

Iaccarino, L., Llibre-Guerra, J. J., Mcdade, E., Edwards, L., Gordon, B., Benzinger, T., Hassenstab, J., Kramer, J. H., Li, Y., Miller, B. L., Miller, Z., Morris, J. C., Mundada, N., Perrin, R. J., Rosen, H. J., Soleimani-Meigooni, D., Strom, A., Tsoy, E., Wang, G. & Xiong, C. & 17 others, Allegri, R., Chrem, P., Vazquez, S., Berman, S. B., Chhatwal, J., Masters, C. L., Farlow, M. R., Jucker, M., Levin, J., Salloway, S., Fox, N. C., Day, G. S., Gorno-Tempini, M. L., Boxer, A. L., La Joie, R., Bateman, R. & Rabinovici, G. D., 2024, In: Brain Communications. 6, 3, fcae159.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Naturalistic assessment of reaction time variability in older adults at risk for Alzheimer's disease

Welhaf, M. S., Wilks, H., Aschenbrenner, A. J., Balota, D. A., Schindler, S. E., Benzinger, T. L. S., Gordon, B. A., Cruchaga, C., Xiong, C., Morris, J. C. & Hassenstab, J., Jun 29 2024, In: Journal of the International Neuropsychological Society. 30, 5, p. 428-438 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Personality predictors of dementia diagnosis and neuropathological burden: An individual participant data meta-analysis

Beck, E. D., Yoneda, T., James, B. D., Bennett, D. A., Hassenstab, J., Katz, M. J., Lipton, R. B., Morris, J., Mroczek, D. K. & Graham, E. K., Mar 2024, In: Alzheimer's and Dementia. 20, 3, p. 1497-1514 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Pick a PACC: Comparing Domain-Specific and General Cognitive Composites in Alzheimer Disease Research

McKay, N. S., Millar, P. R., Nicosia, J., Aschenbrenner, A. J., Gordon, B. A., Benzinger, T. L. S., Cruchaga, C. C., Schindler, S. E., Morris, J. C. & Hassenstab, J., Apr 11 2024, In: Neuropsychology. 38, 5, p. 443-464 22 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Predicting cognitive decline: Which is more useful, baseline amyloid levels or longitudinal change?

Chen, G., McKay, N. S., Gordon, B. A., Liu, J., Joseph-Mathurin, N., Schindler, S. E., Hassenstab, J., Aschenbrenner, A. J., Wang, Q., Schultz, S. A., Su, Y., LaMontagne, P. J., Keefe, S. J., Massoumzadeh, P., Cruchaga, C., Xiong, C., Morris, J. C. & Benzinger, T. L. S., Jan 2024, In: NeuroImage: Clinical. 41, 103551.

Research output: Contribution to journal › Article › peer-review

Open Access

Predictors and outcomes of fluctuations in the clinical dementia rating scale

Wilks, H., Benzinger, T. L. S., Schindler, S. E., Cruchaga, C., Morris, J. C. & Hassenstab, J., Mar 2024, In: Alzheimer's and Dementia. 20, 3, p. 2080-2088 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Relationships of Cognitive Measures with Cerebrospinal Fluid but Not Imaging Biomarkers of Alzheimer Disease Vary between Black and White Individuals

Bonomi, S., Lu, R., Schindler, S. E., Bui, Q., Lah, J. J., Wolk, D., Gleason, C. E., Sperling, R., Roberson, E. D., Levey, A. I., Shaw, L., Van Hulle, C., Benzinger, T., Adams, M., Manzanares, C., Qiu, D., Hassenstab, J., Moulder, K. L., Balls-Berry, J. E. & Johnson, K. & 16 others, Johnson, S. C., Murchison, C. F., Luo, J., Gremminger, E., Agboola, F., Grant, E. A., Hornbeck, R., Massoumzadeh, P., Keefe, S., Dierker, D., Gray, J., Henson, R. L., Streitz, M., Mechanic-Hamilton, D., Morris, J. C. & Xiong, C., Mar 2024, In: Annals of neurology. 95, 3, p. 495-506 12 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Reliability and Validity of Smartphone Cognitive Testing for Frontotemporal Lobar Degeneration

Staffaroni, A. M., Clark, A. L., Taylor, J. C., Heuer, H. W., Sanderson-Cimino, M., Wise, A. B., Dhanam, S., Cobigo, Y., Wolf, A., Manoochehri, M., Forsberg, L., Mester, C., Rankin, K. P., Appleby, B. S., Bayram, E., Bozoki, A., Clark, D., Darby, R. R., Domoto-Reilly, K. & Fields, J. A. & 30 others, Galasko, D., Geschwind, D., Ghoshal, N., Graff-Radford, N., Grossman, M., Hsiung, G. Y., Huey, E. D., Jones, D. T., Lapid, M. I., Litvan, I., Masdeu, J. C., Massimo, L., Mendez, M. F., Miyagawa, T., Pascual, B., Pressman, P., Ramanan, V. K., Ramos, E. M., Rascovsky, K., Roberson, E. D., Tartaglia, M. C., Wong, B., Miller, B. L., Kornak, J., Kremers, W., Hassenstab, J., Kramer, J. H., Boeve, B. F., Rosen, H. J. & Boxer, A. L., 2024, (Accepted/In press) In: JAMA Network Open. p. E244266

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Reliability of the remote digital self-administered Stricker Learning Span, Symbols Test and Mayo Test DRIVE Screening Battery Composite

Hughes, M. A., Frank, R. D., Fan, W. Z., Christianson, T. J., Kremers, W. K., Stricker, J. L., Boots, E. A., Machulda, M. M., Fields, J. A., Hassenstab, J. J., Aduen, P., Lucas, J. A., Graff-Radford, J., Vemuri, P., Jack, C. R., Knopman, D. S., Petersen, R. C. & Stricker, N. H., Dec 2024, In: Alzheimer's and Dementia. 20, S8, e095558.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Sex-Specific Patterns of Body Mass Index Relationship with White Matter Connectivity

Rahmani, F., Wang, Q., McKay, N. S., Keefe, S., Hantler, N., Hornbeck, R., Wang, Y., Hassenstab, J., Schindler, S., Xiong, C., Morris, J. C., Benzinger, T. L. S. & Raji, C. A., 2024, In: Advances in Alzheimer's Disease. 10, p. 457-474 18 p.

Research output: Contribution to journal › Article › peer-review

Unlocking Cognitive Analysis Potential in Alzheimer's Disease Clinical Trials: Investigating Hierarchical Linear Models for Analyzing Novel Measurement Burst Design Data

Wang, G., Hassenstab, J., Li, Y., Aschenbrenner, A. J., McDade, E. M., Llibre-Guerra, J., Bateman, R. J. & Xiong, C., Dec 30 2024, In: Statistics in medicine. 43, 30, p. 5898-5910 13 p.

Research output: Contribution to journal › Article › peer-review

γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS)

Dominantly Inherited Alzheimer Network, Sep 2024, In: The Lancet Neurology. 23, 9, p. 913-924 12 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

2023

Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease

Millar, P. R., Gordon, B. A., Wisch, J. K., Schultz, S. A., Benzinger, T. L., Cruchaga, C., Hassenstab, J. J., Ibanez, L., Karch, C., Llibre-Guerra, J. J., Morris, J. C., Perrin, R. J., Supnet-Bell, C., Xiong, C., Allegri, R. F., Berman, S. B., Chhatwal, J. P., Chrem Mendez, P. A., Day, G. S. & Hofmann, A. & 13 others, Ikeuchi, T., Jucker, M., Lee, J. H., Levin, J., Lopera, F., Niimi, Y., Sánchez-González, V. J., Schofield, P. R., Sosa-Ortiz, A. L., Vöglein, J., Bateman, R. J., Ances, B. M. & McDade, E. M., Dec 2023, In: Molecular neurodegeneration. 18, 1, 98.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

A flexible modeling approach for biomarker-based computation of absolute risk of Alzheimer's disease dementia

Hartz, S. M., Mozersky, J., Schindler, S., Linnenbringer, E., Wang, J., Gordon, B., Raji, C. A., Moulder, K. L., West, T., Benzinger, T. L. S., Cruchaga, C., Hassenstab, J. J., Bierut, L. J., Xiong, C. & Morris, J., Apr 2023, In: Alzheimer's and Dementia. 19, 4, p. 1452-1465 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Alzheimer’s disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals

Pettigrew, C., Nazarovs, J., Soldan, A., Singh, V., Wang, J., Hohman, T., Dumitrescu, L., Libby, J., Kunkle, B., Gross, A. L., Johnson, S., Lu, Q., Engelman, C., Masters, C. L., Maruff, P., Laws, S. M., Morris, J. C., Hassenstab, J., Cruchaga, C. & Resnick, S. M. & 3 others, Kitner-Triolo, M. H., An, Y. & Albert, M., Dec 2023, In: Alzheimer's Research and Therapy. 15, 1, 66.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Association of Stages of Objective Memory Impairment With Incident Symptomatic Cognitive Impairment in Cognitively Normal Individuals

Grober, E., Petersen, K. K., Lipton, R. B., Hassenstab, J., Morris, J. C., Gordon, B. A. & Ezzati, A., May 30 2023, In: Neurology. 100, 22, p. E2279-E2289

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Associations of Stages of Objective Memory Impairment with Cerebrospinal Fluid and Neuroimaging Biomarkers of Alzheimer’s Disease

Petersen, K. K., Ezzati, A., Lipton, R. B., Gordon, B., Hassenstab, J., Morris, J. & Grober, E., Jan 2023, In: The journal of prevention of Alzheimer's disease. 10, 1, p. 112-119 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Biomarker clustering in autosomal dominant Alzheimer's disease

for the Dominantly Inherited Alzheimer Network (DIAN), Jan 2023, In: Alzheimer's and Dementia. 19, 1, p. 274-284 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer’s disease

Dominantly Inherited Alzheimer Network, Wheelock, M. D., Strain, J. F., Mansfield, P., Tu, J. C., Tanenbaum, A., Preische, O., Chhatwal, J. P., Cash, D. M., Cruchaga, C., Fagan, A. M., Fox, N. C., Graff-Radford, N. R., Hassenstab, J., Jack, C. R., Karch, C. M., Levin, J., McDade, E. M., Perrin, R. J. & Schofield, P. R. & 147 others, Xiong, C., Morris, J. C., Bateman, R. J., Jucker, M., Benzinger, T. L. S., Ances, B. M., Eggebrecht, A. T., Gordon, B. A., Adams, S., Allegri, R., Araki, A., Barthelemy, N., Bateman, R., Bechara, J., Benzinger, T., Berman, S., Bodge, C., Brandon, S., Brooks, W., Brosch, J., Buck, J., Buckles, V., Carter, K., Cash, D., Cash, L., Chen, C., Chhatwal, J., Chrem, P., Chua, J., Chui, H., Cruchaga, C., Day, G. S., De La Cruz, C., Denner, D., Diffenbacher, A., Dincer, A., Donahue, T., Douglas, J., Duong, D., Egido, N., Esposito, B., Fagan, A., Farlow, M., Feldman, B., Fitzpatrick, C., Flores, S., Fox, N., Franklin, E., Friedrichsen, N., Fujii, H., Gardener, S., Ghetti, B., Goate, A., Goldberg, S., Goldman, J., Gonzalez, A., Gordon, B., Gräber-Sultan, S., Graff-Radford, N., Graham, M., Gray, J., Gremminger, E., Grilo, M., Groves, A., Haass, C., Häsler, L., Hassenstab, J., Hellm, C., Herries, E., Hoechst-Swisher, L., Hofmann, A., Holtzman, D., Hornbeck, R., Igor, Y., Ihara, R., Ikeuchi, T., Ikonomovic, S., Ishii, K., Jack, C., Jerome, G., Johnson, E., Jucker, M., Karch, C., Käser, S., Kasuga, K., Keefe, S., Klunk, W., Koeppe, R., Koudelis, D., Kuder-Buletta, E., Laske, C., Lee, J. H., Levey, A., Levin, J., Li, Y., Lopez, O., Marsh, J., Martinez, R., Martins, R., Mason, N. S., Masters, C., Mawuenyega, K., McCullough, A., McDade, E., Mejia, A., Morenas-Rodriguez, E., Mori, H., Morris, J., Mountz, J., Mummery, C., Nadkami, N., Nagamatsu, A., Neimeyer, K., Niimi, Y., Noble, J., Norton, J., Nuscher, B., O’Connor, A., Obermüller, U., Patira, R., Perrin, R., Ping, L., Preische, O., Renton, A., Ringman, J., Salloway, S., Sanchez-Valle, R., Schofield, P., Senda, M., Seyfried, N., Shady, K., Shimada, H., Sigurdson, W., Smith, J., Smith, L., Snitz, B., Sohrabi, H., Stephens, S., Taddei, K., Thompson, S., Vöglein, J., Wang, P., Wang, Q., Weamer, E., Xiong, C., Xu, J. & Xu, X., Jul 1 2023, In: Brain. 146, 7, p. 2928-2943 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease

the Dominantly Inherited Alzheimer Network, Johnson, E. C. B., Bian, S., Haque, R. U., Carter, E. K., Watson, C. M., Gordon, B. A., Ping, L., Duong, D. M., Epstein, M. P., McDade, E., Barthélemy, N. R., Karch, C. M., Xiong, C., Cruchaga, C., Perrin, R. J., Wingo, A. P., Wingo, T. S., Chhatwal, J. P. & Day, G. S. & 120 others, Noble, J. M., Berman, S. B., Martins, R., Graff-Radford, N. R., Schofield, P. R., Ikeuchi, T., Mori, H., Levin, J., Farlow, M., Lah, J. J., Haass, C., Jucker, M., Morris, J. C., Benzinger, T. L. S., Roberts, B. R., Bateman, R. J., Fagan, A. M., Seyfried, N. T., Levey, A. I., Noble, J. M., Day, G., Graff-Radford, N. R., Voglein, J., Allegri, R., Mendez, P. C., Surace, E., Ikonomovic, S., Nadkarni, N., Lopera, F., Ramirez, L., Aguillon, D., Leon, Y., Ramos, C., Alzate, D., Baena, A., Londono, N., Moreno, S., Laske, C., Kuder-Buletta, E., Graber-Sultan, S., Preische, O., Hofmann, A., Ikeuchi, T., Kasuga, K., Niimi, Y., Ishii, K., Senda, M., Sanchez-Valle, R., Rosa-Neto, P., Fox, N., Cash, D., Lee, J. H., Roh, J. H., Riddle, M., Menard, W., Bodge, C., Surti, M., Takada, L. T., Chhatwal, J. P., Sanchez-Gonzalez, V. J., Orozco-Barajas, M., Goate, A., Renton, A., Esposito, B., Karch, C. M., Marsh, J., Cruchaga, C., Fernandez, V., Gordon, B., Fagan, A. M., Jerome, G., Herries, E., Llibre-Guerra, J., Johnson, E. C. B., Seyfried, N. T., Schofield, P. R., Brooks, W., Bechara, J., Bateman, R. J., Hassenstab, J., Perrin, R. J., Franklin, E., Benzinger, T. L. S., Chen, A., Chen, C., Flores, S., Friedrichsen, N., Hantler, N., Hornbeck, R., Jarman, S., Keefe, S., Koudelis, D., Massoumzadeh, P., McCullough, A., McKay, N., Nicklaus, J., Pulizos, C., Wang, Q., Mishall, S., Sabaredzovic, E., Deng, E., Candela, M., Smith, H., Hobbs, D., Scott, J., Levin, J., Xiong, C., Wang, P., Xu, X., Li, Y., Gremminger, E., Ma, Y., Bui, R., Lu, R., Ortiz, A. L. S., Daniels, A., Courtney, L., Supnet-Bell, C., Xu, J. & Ringman, J., Aug 2023, In: Nature medicine. 29, 8, p. 1979-1988 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

63 Scopus citations

Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer's Disease

and the Dominantly Inherited Alzheimer Network, Horie, K., Li, Y., Barthelemy, N., Gordon, B., Hassenstab, J., Benzinger, T., Niven, A., Morris, J., Karch, C. M., Xiong, C., Allegri, R., Mendez, P. C., Ikeuchi, T., Kasuga, K., Noble, J., Farlow, M., Chhatwal, J., Day, G. & Schofield, P. R. & 11 others, Masters, C. L., Levin, J., Jucker, M., Lee, J. H., Roh, J. H., Sato, C., Sachdev, P., Koyama, A., Reyderman, L., Bateman, R. J. & McDade, E., Jun 2023, In: Annals of neurology. 93, 6, p. 1158-1172 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study

Alzheimer's Biomarker Consortium-Down Syndrome, Dominantly Inherited Alzheimer Network, Boerwinkle, A. H., Gordon, B. A., Wisch, J., Flores, S., Henson, R. L., Butt, O. H., McKay, N., Chen, C. D., Benzinger, T. L. S., Fagan, A. M., Cruchaga, C., Perrin, R. J., Xiong, C., Hassenstab, J., McDade, E., Bateman, R. J., Ances, B. M. & Barthelemy, N. & 8 others, Buckles, V., Day, G., Joseph-Mathurin, N., Holtzman, D., Karch, C., Li, Y., Wang, Q. & Xu, J., Jan 2023, In: The Lancet Neurology. 22, 1, p. 55-65 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's disease

and Dominantly Inherited Alzheimer Network (DIAN), Xiong, C., McCue, L. M., Buckles, V., Grant, E., Agboola, F., Coble, D., Bateman, R. J., Fagan, A. M., Benzinger, T. L. S., Hassenstab, J., Schindler, S. E., McDade, E., Moulder, K., Gordon, B. A., Cruchaga, C., Day, G. S., Ikeuchi, T., Suzuki, K. & Allegri, R. F. & 3 others, Vöglein, J., Levin, J. & Morris, J. C., Jul 2023, In: Alzheimer's and Dementia. 19, 7, p. 2923-2932 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease

Shirzadi, Z., Schultz, S. A., Yau, W. Y. W., Joseph-Mathurin, N., Fitzpatrick, C. D., Levin, R., Kantarci, K., Preboske, G. M., Jack, C. R., Farlow, M. R., Hassenstab, J., Jucker, M., Morris, J. C., Xiong, C., Karch, C. M., Levey, A. I., Gordon, B. A., Schofield, P. R., Salloway, S. P. & Perrin, R. J. & 26 others, McDade, E., Levin, J., Cruchaga, C., Allegri, R. F., Fox, N. C., Goate, A., Day, G. S., Koeppe, R., Chui, H. C., Berman, S., Mori, H., Sanchez-Valle, R., Lee, J. H., Rosa-Neto, P., Ruthirakuhan, M., Wu, C. Y., Swardfager, W., Benzinger, T. L. S., Sohrabi, H. R., Martins, R. N., Bateman, R. J., Johnson, K. A., Sperling, R. A., Greenberg, S. M., Schultz, A. P. & Chhatwal, J. P., Dec 11 2023, In: JAMA Neurology. 80, 12, p. 1353-1363 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

First presentation with neuropsychiatric symptoms in autosomal dominant Alzheimer's disease: The Dominantly Inherited Alzheimer's Network Study

O'Connor, A., Rice, H., Barnes, J., Ryan, N. S., Liu, K. Y., Allegri, R. F., Berman, S., Ringman, J. M., Cruchaga, C., Farlow, M. R., Hassenstab, J., Lee, J. H., Perrin, R. J., Xiong, C., Gordon, B., Levey, A. I., Goate, A., Graff-Radford, N., Levin, J. & Jucker, M. & 13 others, Benzinger, T., McDade, E., Mori, H., Noble, J. M., Schofield, P. R., Martins, R. N., Salloway, S., Chhatwal, J., Morris, J. C., Bateman, R., Howard, R., Reeves, S. & Fox, N. C., May 1 2023, In: Journal of Neurology, Neurosurgery and Psychiatry. 94, 5, p. 403-405 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Increased Cognitive Effort Costs in Healthy Aging and Preclinical Alzheimer's Disease

Aschenbrenner, A. J., Crawford, J. L., Peelle, J. E., Fagan, A. M., Benzinger, T. L. S., Morris, J. C., Hassenstab, J. & Braver, T. S., Apr 17 2023, In: Psychology and Aging. 38, 5, p. 428-442 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease

Schultz, S. A., Shirzadi, Z., Schultz, A. P., Liu, L., Fitzpatrick, C. D., McDade, E., Barthelemy, N. R., Renton, A., Esposito, B., Joseph-Mathurin, N., Cruchaga, C., Chen, C. D., Goate, A., Allegri, R. F., Benzinger, T. L. S., Berman, S., Chui, H. C., Fagan, A. M., Farlow, M. R. & Fox, N. C. & 27 others, Gordon, B. A., Day, G. S., Graff-Radford, N. R., Hassenstab, J. J., Hanseeuw, B. J., Hofmann, A., Jack, C. R., Jucker, M., Karch, C. M., Koeppe, R. A., Lee, J. H., Levey, A. I., Levin, J., Martins, R. N., Mori, H., Morris, J. C., Noble, J., Perrin, R. J., Rosa-Neto, P., Salloway, S. P., Sanchez-Valle, R., Schofield, P. R., Xiong, C., Johnson, K. A., Bateman, R. J., Sperling, R. A. & Chhatwal, J. P., Aug 2023, In: Aging Cell. 22, 8, e13871.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Jason Hassenstab

Research output

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