Personal profile
Research interests
Jason Hassenstab, PhD, is the Norman J. Stupp Professor of Neurology and Professor of Psychological and Brain Sciences and the director of the Cognitive Technology Research Laboratory (CTRLab) at Washington University in St. Louis. He is the Principal Investigator of the ARC-Down syndrome study, an international study of Down syndrome associated Alzheimer's disease. He also leads the Cognition Cores for the Dominantly-Inherited Alzheimer Network-Trials Unit (DIAN-TU) and the DIAN observational study and the Charles F. and Joanne Knight Alzheimer’s Disease Research Center. The CTRLab’s focus in on using technology to improve cognitive assessments in Alzheimer’s disease and other disorders. We use measurement burst designs, based on principles from ecological momentary assessment, to measure cognition rapidly and frequently on smartphones in normal and clinical populations. We also develop web-based cognitive assessments designed to be sensitive to the very earliest stages of neurodegenerative disease. Dr. Hassenstab has been continuously funded by the NIH since 2007 and also receives funding from foundations. Prior to pursuing academics, Dr. Hassenstab toured internationally as a professional jazz saxophonist, often sporting a purple pinstriped zoot suit, and made hundreds of dollars. He completed a bachelor’s degree in Jazz and Contemporary Music Performance at New York University and a PhD in psychology under mentorship of Dr. Antonio Convit at New York University and Fordham University. He then completed a Fellowship at Brown University and joined the faculty at Washington University in St. Louis in 2010.
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Collaborations and top research areas from the last five years
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A coordinated analysis of bidirectional associations between life satisfaction and cognitive function
Hill, K. C., Pfund, G. N., Rule, P. D., Hill, P. L., James, B. D., Hassenstab, J. J., Huisman, M. & Willroth, E. C., Feb 1 2026, In: Journal of Personality and Social Psychology. 130, 2, p. 357-372 16 p.Research output: Contribution to journal › Article › peer-review
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Harmonizing neuropsychological test data across prospective studies
for the Alzheimer's Disease Neuroimaging Initiative, OASIS-3, and the Australian Imaging Biomarkers and Lifestyle flagship study of ageing, Feb 2026, In: Alzheimer's and Dementia. 22, 2, e71186.Research output: Contribution to journal › Article › peer-review
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Remote assessments of sleep and cognition in cognitively normal older adults at risk for Alzheimer disease
Wilks, H. M., Welhaf, M. S., Aschenbrenner, A. J., Carpenter, B. D., Gordon, B. A., Schindler, S. E., Lucey, B. P., Morris, J. C. & Hassenstab, J., Mar 2026, In: Sleep Medicine. 139, 108734.Research output: Contribution to journal › Article › peer-review
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Analyzing heterogeneity in Alzheimer disease using multimodal normative modeling on imaging-based ATN biomarkers
for the Alzheimer's Disease Neuroimaging Initiative, Apr 2025, In: Alzheimer's and Dementia. 21, 4, e70143.Research output: Contribution to journal › Article › peer-review
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A scoping review of remote and unsupervised digital cognitive assessments in preclinical Alzheimer’s disease
Polk, S. E., Öhman, F., Hassenstab, J., König, A., Papp, K. V., Schöll, M. & Berron, D., Dec 2025, In: npj Digital Medicine. 8, 1, 266.Research output: Contribution to journal › Article › peer-review
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