James Wedner

2023

Insights into the pathogenesis of hereditary angioedema using genetic sequencing and recombinant protein expression analyses

Ren, Z., Zhao, S., Li, T., Wedner, H. J. & Atkinson, J. P., Apr 2023, In: Journal of Allergy and Clinical Immunology. 151, 4, p. 1040-1049.e5

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Lanadelumab in Patients 2 to Less Than 12 Years Old With Hereditary Angioedema: Results From the Phase 3 SPRING Study

SPRING Investigators, 2023, (Accepted/In press) In: Journal of Allergy and Clinical Immunology: In Practice.

Research output: Contribution to journal › Article › peer-review

Open Access

Mepolizumab improvements in health-related quality of life and disease symptoms in a patient population with very severe chronic rhinosinusitis with nasal polyps: psychometric and efficacy analyses from the SYNAPSE study

SYNAPSE study group & Wedner, H. J., Dec 2023, In: Journal of Patient-Reported Outcomes. 7, 1, 4.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2022

Long-term prevention of hereditary angioedema attacks with lanadelumab: The HELP OLE Study

for the HELP OLE Investigators, Mar 2022, In: Allergy: European Journal of Allergy and Clinical Immunology. 77, 3, p. 979-990 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Optimization of care for patients with hereditary angioedema living in rural areas

Riedl, M. A., Johnston, D. T., Anderson, J., Meadows, J. A., Soteres, D., LeBlanc, S. B., Wedner, H. J. & Lang, D. M., May 2022, In: Annals of Allergy, Asthma and Immunology. 128, 5, p. 526-533 8 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Scopus citations

SARS-CoV-2 booster vaccination rescues attenuated IgG1 memory B cell response in primary antibody deficiency patients

Lin, F. J., Doss, A. M. A., Davis-Adams, H. G., Adams, L. J., Hanson, C. H., VanBlargan, L. A., Liang, C. Y., Chen, R. E., Monroy, J. M., Wedner, H. J., Kulczycki, A., Mantia, T. L., O’Shaughnessy, C. C., Raju, S., Zhao, F. R., Rizzi, E., Rigell, C. J., Dy, T. B., Kau, A. L., Ren, Z., & 10 othersTurner, J. S., O’Halloran, J. A., Presti, R. M., Fremont, D. H., Kendall, P. L., Ellebedy, A. H., Mudd, P. A., Diamond, M. S., Zimmerman, O. & Laidlaw, B. J., Dec 22 2022, In: Frontiers in immunology. 13, 1033770.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Effectiveness of lanadelumab for preventing hereditary angioedema attacks: Subgroup analyses from the HELP study

HELP Study Investigators, Oct 2021, In: Clinical and Experimental Allergy. 51, 10, p. 1391-1395 5 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

1 Scopus citations

Impact of lanadelumab on health-related quality of life in patients with hereditary angioedema in the HELP study

on behalf of the HELP Study Investigators, Apr 2021, In: Allergy: European Journal of Allergy and Clinical Immunology. 76, 4, p. 1188-1198 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial

SYNAPSE study investigators, Oct 2021, In: The Lancet Respiratory Medicine. 9, 10, p. 1141-1153 13 p.

Research output: Contribution to journal › Article › peer-review

256 Scopus citations

Oral once-daily berotralstat for the prevention of hereditary angioedema attacks: A randomized, double-blind, placebo-controlled phase 3 trial

Zuraw, B., Lumry, W. R., Johnston, D. T., Aygören-Pürsün, E., Banerji, A., Bernstein, J. A., Christiansen, S. C., Jacobs, J. S., Sitz, K. V., Gower, R. G., Gagnon, R., Wedner, H. J., Kinaciyan, T., Hakl, R., Hanzlíková, J., Anderson, J. T., McNeil, D. L., Fritz, S. B., Yang, W. H., Tachdjian, R., & 16 othersBusse, P. J., Craig, T. J., Li, H. H., Farkas, H., Best, J. M., Clemons, D., Cornpropst, M., Dobo, S. M., Iocca, H. A., Kargl, D., Nagy, E., Murray, S. C., Collis, P., Sheridan, W. P., Maurer, M. & Riedl, M. A., Jul 2021, In: Journal of Allergy and Clinical Immunology. 148, 1, p. 164-172.e9

Research output: Contribution to journal › Article › peer-review

Open Access

74 Scopus citations

Randomized Trial of the Efficacy and Safety of Berotralstat (BCX7353) as an Oral Prophylactic Therapy for Hereditary Angioedema: Results of APeX-2 Through 48 Weeks (Part 2)

Wedner, H. J., Aygören-Pürsün, E., Bernstein, J., Craig, T., Gower, R., Jacobs, J. S., Johnston, D. T., Lumry, W. R., Zuraw, B. L., Best, J. M., Iocca, H. A., Murray, S. C., Desai, B., Nagy, E., Sheridan, W. P. & Kiani-Alikhan, S., Jun 2021, In: Journal of Allergy and Clinical Immunology: In Practice. 9, 6, p. 2305-2314.e4

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

2020

Association Between Self-Reported Dental Hygiene Practices and Dental Procedure-Related Recurrent Angioedema Attacks in HAE Subjects: A Multicenter Survey

Singh, U., Lumry, W. R., Busse, P., Wedner, H. J., Banerji, A., Craig, T. J., Li, H. H., Tachdjian, R., Jacobs, J. S., Riedl, M. A., Davis-Lorton, M., Christiansen, S. C., Zuraw, B. L. & Bernstein, J. A., Oct 2020, In: Journal of Allergy and Clinical Immunology: In Practice. 8, 9, p. 3162-3169.e5

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Hereditary angioedema: Pathophysiology (HAE type I, HAE type II, and HAE nC1-INH)

Wedner, H. J., Nov 2020, In: Allergy and asthma proceedings. 41, 6, p. S14-S17

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Lanadelumab demonstrates rapid and sustained prevention of hereditary angioedema attacks

for the HELP Investigators, Nov 1 2020, In: Allergy: European Journal of Allergy and Clinical Immunology. 75, 11, p. 2879-2887 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

2019

Fixed-Dose Subcutaneous C1-Inhibitor Liquid for Prophylactic Treatment of C1-INH-HAE: SAHARA Randomized Study

SAHARA study group, May 1 2019, In: Journal of Allergy and Clinical Immunology: In Practice. 7, 5, p. 1610-1618.e4

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Immune globulin subcutaneous, human-klhw 20% for primary humoral immunodeficiency: An open-label, Phase III study

Sleasman, J. W., Lumry, W. R., Hussain, I., Wedner, H. J., Harris, J. B., Courtney, K. L., Mondou, E., Lin, J. & Stein, M. R., 2019, In: Immunotherapy. 11, 16, p. 1371-1386 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Impact of weather and climate change with indoor and outdoor air quality in asthma: A Work Group Report of the AAAAI Environmental Exposure and Respiratory Health Committee

Poole, J. A., Barnes, C. S., Demain, J. G., Bernstein, J. A., Padukudru, M. A., Sheehan, W. J., Fogelbach, G. G., Wedner, J., Codina, R., Levetin, E., Cohn, J. R., Kagen, S., Portnoy, J. M. & Nel, A. E., May 2019, In: Journal of Allergy and Clinical Immunology. 143, 5, p. 1702-1710 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Scopus citations

Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen

Satyaraj, E., Wedner, H. J. & Bousquet, J., Oct 1 2019, In: Allergy: European Journal of Allergy and Clinical Immunology. 74, S107, p. 5-17 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Penicillin Allergy Evaluation: A Prospective, Multicenter, Open-Label Evaluation of a Comprehensive Penicillin Skin Test Kit

Solensky, R., Jacobs, J., Lester, M., Lieberman, P., McCafferty, F., Nilsson, T., Park, M., Schwarz, G., Soong, W., Wagelie-Steffen, A., Wedner, H. J., Weiss, M., Windom, H., Tonascia, J., Yates, K. P., Mendelson, L. M., Wolfe, J. & Adkinson, N. F., Jul 1 2019, In: Journal of Allergy and Clinical Immunology: In Practice. 7, 6, p. 1876-1885.e3

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

2018

Effect of Lanadelumab Compared with Placebo on Prevention of Hereditary Angioedema Attacks: A Randomized Clinical Trial

Banerji, A., Riedl, M. A., Bernstein, J. A., Cicardi, M., Longhurst, H. J., Zuraw, B. L., Busse, P. J., Anderson, J., Magerl, M., Martinez-Saguer, I., Davis-Lorton, M., Zanichelli, A., Li, H. H., Craig, T., Jacobs, J., Johnston, D. T., Shapiro, R., Yang, W. H., Lumry, W. R., Manning, M. E., & 15 othersSchwartz, L. B., Shennak, M., Soteres, D., Zaragoza-Urdaz, R. H., Gierer, S., Smith, A. M., Tachdjian, R., Wedner, H. J., Hebert, J., Rehman, S. M., Staubach, P., Schranz, J., Baptista, J., Nothaft, W. & Maurer, M., Nov 27 2018, In: JAMA - Journal of the American Medical Association. 320, 20, p. 2108-2121 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

169 Scopus citations

Evaluation of avoralstat, an oral kallikrein inhibitor, in a Phase 3 hereditary angioedema prophylaxis trial: The OPuS-2 study

Riedl, M. A., Aygören-Pürsün, E., Baker, J., Farkas, H., Anderson, J., Bernstein, J. A., Bouillet, L., Busse, P., Manning, M., Magerl, M., Gompels, M., Huissoon, A. P., Longhurst, H., Lumry, W., Ritchie, B., Shapiro, R., Soteres, D., Banerji, A., Cancian, M., Johnston, D. T., & 17 othersCraig, T. J., Launay, D., Li, H. H., Liebhaber, M., Nickel, T., Offenberger, J., Rae, W., Schrijvers, R., Triggiani, M., Wedner, H. J., Dobo, S., Cornpropst, M., Clemons, D., Fang, L., Collis, P., Sheridan, W. P. & Maurer, M., Sep 2018, In: Allergy: European Journal of Allergy and Clinical Immunology. 73, 9, p. 1871-1880 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

2017

Inhibiting plasma kallikrein for hereditary angioedema prophylaxis

Banerji, A., Busse, P., Shennak, M., Lumry, W., Davis-Lorton, M., Wedner, H. J., Jacobs, J., Baker, J., Bernstein, J. A., Lockey, R., Li, H. H., Craig, T., Cicardi, M., Riedl, M., Al-Ghazawi, A., Soo, C., Iarrobino, R., Sexton, D. J., Tenhoor, C., Kenniston, J. A., & 8 othersFaucette, R., Still, J. G., Kushner, H., Mensah, R., Stevens, C., Biedenkapp, J. C., Chyung, Y. & Adelman, B., Feb 23 2017, In: New England Journal of Medicine. 376, 8, p. 717-728 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

130 Scopus citations

Something new in the air: Paying for community-based environmental approaches to asthma prevention and control

Tschudy, M. M., Sharfstein, J., Matsui, E., Barnes, C. S., Chacker, S., Codina, R., Cohn, J. R., Sandel, M. & Wedner, H. J., Nov 2017, In: Journal of Allergy and Clinical Immunology. 140, 5, p. 1244-1249 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2016

A critical review of perfluorooctanoate and perfluorooctanesulfonate exposure and immunological health conditions in humans

Chang, E. T., Adami, H. O., Boffetta, P., Wedner, H. J. & Mandel, J. S., Apr 20 2016, In: Critical Reviews in Toxicology. 46, 4, p. 279-331 53 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

116 Scopus citations

Safety and Usage of C1-Inhibitor in Hereditary Angioedema: Berinert Registry Data

Riedl, M. A., Bygum, A., Lumry, W., Magerl, M., Bernstein, J. A., Busse, P., Craig, T., Frank, M. M., Edelman, J., Williams-Herman, D., Feuersenger, H., Rojavin, M., Offenberger, J., Levy, R., Hurewitz, D., Li, H. H., Shapiro, R., Bernstein, J., Craig, T., Davis, A., & 27 othersRosch, J., Fox, J., Janss, G., Baker, J., Packer, F., Vegh, A., Frank, M., Sher, E., Busse, P., Wedner, J. H., Riedl, M., Lumry, W., Amrol, D., Gower, R., Silber, G., Portnoy, J., Paris, K., Darter, A., Mumneh, N., Petrov, A., Schneider, L., Martinez-Saguer, I., Staubach-Renz, P., Maurer, M., Bas, M., Aygören-Pürsün, E. & Wuillemin, W., Sep 1 2016, In: Journal of Allergy and Clinical Immunology: In Practice. 4, 5, p. 963-971 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

2015

Evaluating results of outcome studies of biological drugs

Korenblat, P. E. & Wedner, H. J., Sep 1 2015, In: The Lancet Respiratory Medicine. 3, 9, p. 664-665 2 p., 197.

Research output: Contribution to journal › Comment/debate

1 Scopus citations

2013

Safety of aspirin desensitization in patients with reported aspirin allergy and cardiovascular disease

McMullan, K. L. & Wedner, H. J., Jan 2013, In: Clinical Cardiology. 36, 1, p. 25-30 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

2011

Factors that predict the success of cyclosporine treatment for chronic urticaria

Hollander, S. M., Joo, S. S. & Wedner, H. J., Dec 2011, In: Annals of Allergy, Asthma and Immunology. 107, 6, p. 523-528 6 p.

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

2010

Air filters and air cleaners: Rostrum by the American Academy of Allergy, Asthma & Immunology Indoor Allergen Committee

Sublett, J. L., Seltzer, J., Burkhead, R., Williams, P. B., Wedner, H. J. & Phipatanakul, W., Jan 2010, In: Journal of Allergy and Clinical Immunology. 125, 1-3, p. 32-38 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Scopus citations

2006

Elective penicillin skin testing in a pediatric outpatient setting

Jost, B. C., Wedner, H. J. & Bloomberg, G. R., Dec 2006, In: Annals of Allergy, Asthma and Immunology. 97, 6, p. 807-812 6 p.

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

2004

Eosinophilia in an Iranian woman

Mian, R. R., Ramos, M. S. & Wedner, H. J., Jun 2004, In: Annals of Allergy, Asthma and Immunology. 92, 6, p. 598-603 6 p.

Research output: Contribution to journal › Article › peer-review

2000

Deuteromycete aerobiology and skin-reactivity patterns: A two year concurrent study in Corpus Christi, Texas, USA

Dixit, A., Lewis, W., Baty, J., Crozier, W. & Wedner, 2000, In: Grana. 39, 4, p. 209-218 10 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

1999

A randomized clinical trial to reduce asthma morbidity among inner-city children: Results of the national cooperative inner-city asthma study

Evans, R., Gergen, P. J., Mitchell, H., Kattan, M., Kercsmar, C., Crain, E., Anderson, J., Eggleston, P., Malveaux, F. J. & Wedner, H. J., 1999, In: Journal of Pediatrics. 135, 3, p. 332-338 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

295 Scopus citations

1998

Successful techniques for retention of study participants in an inner-city population

Senturia, Y. D., McNiff Mortimer, K., Baker, D., Gergen, P., Mitchell, H., Joseph, C. & Wedner, H. J., Dec 1998, In: Controlled clinical trials. 19, 6, p. 544-554 11 p.

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

1997

Characteristics of inner-city children with asthma: The National Cooperative Inner-City Asthma Study

Kattan, M., Mitchell, H., Eggleston, P., Gergen, P., Crain, E., Redline, S., Weiss, K., Evans, R., Kaslow, R., Kercsmar, C., Leickly, F., Malveaux, F., Wedner, H. J. & Smartt, E., Oct 1 1997, In: Pediatric Pulmonology. 24, 4, p. 253-262 10 p.

Research output: Contribution to journal › Article › peer-review

320 Scopus citations

Design and methods of the National Cooperative Inner-City Asthma Study

Mitchell, H., Senturia, Y., Gergen, P., Baker, D., Joseph, C., McNiff-Mortimer, K., Wedner, H. J., Crain, E., Eggleston, P., Evans, R., Kattan, M., Kercsmar, C., Leickly, F., Malveaux, F., Smartt, E. & Weiss, K., Oct 1997, In: Pediatric Pulmonology. 24, 4, p. 237-252 16 p.

Research output: Contribution to journal › Article › peer-review

136 Scopus citations

Psychosocial characteristics of inner-city children with asthma: A description of the NCICAS psychosocial protocol

Wade, S., Weil, C., Holden, G., Mitchell, H., Evans, R., Kruszon-Moran, D., Bauman, L., Crain, E., Eggleston, P., Kattan, M., Kercsmar, C., Leickly, F., Malveaux, F., Wedner, H. J. & Smartt, E., Oct 1 1997, In: Pediatric Pulmonology. 24, 4, p. 263-276 14 p.

Research output: Contribution to journal › Article › peer-review

155 Scopus citations

1996

Articulation of asthma and its care among low-income emergency care recipients

Munro, J. F., Haire-Joshu, D., Fisher, E. B. & Wedner, H. J., 1996, In: Journal of Asthma. 33, 5, p. 313-325 13 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

1994

Chronic fatigue syndrome: Point and counterpoint

Straus, S. E., Komaroff, A. L. & Wedner, H. J., Jul 1994, In: Journal of Infectious Diseases. 170, 1, p. 1-6 6 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

1993

A comparison of patient attitudes toward asthma self-management among acute and preventive care settings

Haire-Joshu, D., Fisher, E. B., Munro, J. & Wedner, H. J., 1993, In: Journal of Asthma. 30, 5, p. 359-371 13 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

1992

Grass aeropollen of the western United States Gulf Coast

Lewis, W. H., Dixit, A. B. & Wednet, H. J., 1992, In: International Archives of Allergy and Immunology. 98, 1, p. 80-88 9 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

The allergens of Epicoccum nigrum link. I. Identification of the allergens by immunoblotting

Dixit, A. B., Lewis, W. H. & Wedner, H. J., Jul 1992, In: The Journal of Allergy and Clinical Immunology. 90, 1, p. 11-20 10 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

1991

Aeropollen of weeds of the western United States Gulf Coast

Lewis, W. H., Dixit, A. B. & Wedner, H. J., Jan 1 1991, In: Annals of Allergy. 67, 1, p. 47-52 6 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Asteraceae aeropollen of the western United States Gulf Coast

Lewis, W. H., Dixit, A. B. & Wedner, H. J., 1991, In: Annals of Allergy. 67, 1, p. 37-46 10 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Drug allergy prevention and treatment

Wedner, H. J., Jan 1 1991, In: Immunology and Allergy Clinics of North America. 11, 3, p. 679-694 16 p.

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Ritualistic use of the holly Ilex guayusa by Amazonian Jivaro Indians

Lewis, W. H., Kennelly, E. J., Bass, G. N., Wedner, H. J., Elvin-Lewis, M. P. & W., D. F., 1991, In: Journal of Ethnopharmacology. 33, 1-2, p. 25-30 6 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

The role of glutathione in lymphocyte activation- II. Effects of buthionine sulfoximine and 2-cyclohexene-1-one on early and late activation events

Hamilos, D. L., Mascali, J. J. & Wedner, H. J., 1991, In: International Journal of Immunopharmacology. 13, 1, p. 75-90 16 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

1990

Aeropollen of herbaceous plants at Corpus Christi, Texas

Lewis, W. H., Dixit, A. B. & Wedner, H. J., Dec 1990, In: Aerobiologia. 6, 2, p. 141-146 6 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Committee report of the training program director's committee of the American Academy of Allergy and Immunology: Recommendations of five subcommittees at a retreat held in January 1989

Shearer, W. T., Wedner, H. J., Shapiro, G., Yunginger, J., Kaliner, M. & Anderson, J., 1990, In: Journal of Allergy and Clinical Immunology. 85, 1 I, p. 132-136 5 p.

Research output: Contribution to journal › Comment/debate

Phytohemagglutinin rapidly lyses S49 T-lymphoma cells and the cytotoxicity is not mediated by generation of cAMP or increase in cytosolic calcium

Gupta, A., Hruska, K. A. & Wedner, H. J., Aug 16 1990, In: Biochemical and Biophysical Research Communications. 170, 3, p. 1035-1043 9 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

James Wedner

Research output

Search results