Research output per year
Research output per year
Personal profile
Research interests
Our laboratory focuses on understanding how Taspase1 and MLL regulate critical biological pathways with a special emphasis on cancer biology. Specifically, we’d like to utilize combined biochemical and genetic approaches to investigate how the evolutionarily conserved protease, Taspase1, and its substrates such as MLL coordinate essential cellular and developmental processes.
Areas of Clinical Interest
Kidney cancer, rare kidney cancer, targeted therapy, immunotherapy, precision medicine
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A Single-arm, Multicenter, Phase 2 Study of Lenvatinib Plus Everolimus in Patients with Advanced Non-Clear Cell Renal Cell Carcinoma
Hutson, T. E., Michaelson, M. D., Kuzel, T. M., Agarwal, N., Molina, A. M., Hsieh, J. J., Vaishampayan, U. N., Xie, R., Bapat, U., Ye, W., Jain, R. K. & Fishman, M. N., Aug 2021, In: European Urology. 80, 2, p. 162-170 9 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Lenvatinib plus pembrolizumab in patients with either treatment-naive or previously treated metastatic renal cell carcinoma (Study 111/KEYNOTE-146): a phase 1b/2 study
Lee, C. H., Shah, A. Y., Rasco, D., Rao, A., Taylor, M. H., Di Simone, C., Hsieh, J. J., Pinto, A., Shaffer, D. R., Girones Sarrio, R., Cohn, A. L., Vogelzang, N. J., Bilen, M. A., Gunnestad Ribe, S., Goksel, M., Tennøe, Ø. K., Richards, D., Sweis, R. F., Courtright, J., Heinrich, D. & 8 others, , Jul 2021, In: The Lancet Oncology. 22, 7, p. 946-958 13 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma
CheckMate 9ER Investigators, Mar 4 2021, In: New England Journal of Medicine. 384, 9, p. 829-841 13 p.Research output: Contribution to journal › Article › peer-review
74 Scopus citations -
Single-cell spatial proteomic revelations on the multiparametric MRI heterogeneity of clinically significant prostate cancer
Pachynski, R. K., Kim, E. H., Miheecheva, N., Kotlov, N., Ramachandran, A., Postovalova, E., Galkin, I., Svekolkin, V., Lyu, Y., Zou, Q., Cao, D., Gaut, J., Ippolito, J. E., Bagaev, A., Bruttan, M., Gancharova, O., Nomie, K., Tsiper, M., Andriole, G. L., Ataullakhanov, R. & 1 others, , Jun 2021, In: Clinical Cancer Research. 27, 12, p. 3478-3490 13 p.Research output: Contribution to journal › Article › peer-review
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Structural insights into the function of the catalytically active human Taspase1
Nagaratnam, N., Delker, S. L., Jernigan, R., Edwards, T. E., Snider, J., Thifault, D., Williams, D., Nannenga, B. L., Stofega, M., Sambucetti, L., Hsieh, J. J., Flint, A. J., Fromme, P. & Martin-Garcia, J. M., Aug 5 2021, In: Structure. 29, 8, p. 873-885.e5Research output: Contribution to journal › Article › peer-review