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Personal profile

Research interests

Our laboratory focuses on understanding how Taspase1 and MLL regulate critical biological pathways with a special emphasis on cancer biology. Specifically, we’d like to utilize combined biochemical and genetic approaches to investigate how the evolutionarily conserved protease, Taspase1, and its substrates such as MLL coordinate essential cellular and developmental processes.

Areas of Clinical Interest

Kidney cancer, rare kidney cancer, targeted therapy, immunotherapy, precision medicine

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Research Output

2 Scopus citations

Erratum: Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma (Cell (2019) 179(4) (964–983.e31), (S0092867419311237), (10.1016/j.cell.2019.10.007))

Clinical Proteomic Tumor Analysis Consortium, Jan 9 2020, In : Cell. 180, 1, 1 p.

Research output: Contribution to journalComment/debate

Open Access
  • 2 Scopus citations

    Exploiting the circuit breaker cancer evolution model in human clear cell renal cell carcinoma

    Hsieh, J. J. & Cheng, E. H., Aug 2020, In : Cell Stress. 4, 8, p. 191-198 8 p.

    Research output: Contribution to journalArticle

    Open Access
  • Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts

    Kim, K., Hu, W., Audenet, F., Almassi, N., Hanrahan, A. J., Murray, K., Bagrodia, A., Wong, N., Clinton, T. N., Dason, S., Mohan, V., Jebiwott, S., Nagar, K., Gao, J., Penson, A., Hughes, C., Gordon, B., Chen, Z., Dong, Y., Watson, P. A. & 17 others, Alvim, R., Elzein, A., Gao, S. P., Cocco, E., Santin, A. D., Ostrovnaya, I., Hsieh, J. J., Sagi, I., Pietzak, E. J., Hakimi, A. A., Rosenberg, J. E., Iyer, G., Vargas, H. A., Scaltriti, M., Al-Ahmadie, H., Solit, D. B. & Coleman, J. A., Dec 1 2020, In : Nature communications. 11, 1, 1975.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Molecular characterization of sarcomatoid clear cell renal cell carcinoma unveils new candidate oncogenic drivers

    Malouf, G. G., Flippot, R., Dong, Y., Dinatale, R. G., Chen, Y. B., Su, X., Compérat, E., Rouprêt, M., Mano, R., Blum, K. A., Yao, H., Mouawad, R., Spano, J. P., Khayat, D., Karam, J. A., Ho, T. H., Tickoo, S. K., Russo, P., Hsieh, J. J., Tannir, N. M. & 1 others, Hakimi, A. A., Dec 1 2020, In : Scientific reports. 10, 1, 701.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations