Personal profile
Research interests
Jai Rudra's lab is interested in the development of nano-scale biomaterials such as nanofibers, nanoparticles, virus-like particles, and hydrogels for engaging the immune system to induce protective antibody and cell-mediated immune responses against diseases such as tuberculosis, melanoma and flavivirus infections (West Nile and Zika). His is also investigating the development of vaccines against drugs of addiction such as cocaine.
Biomaterials immunoengineering is a multidisciplinary field that lies at the intersection of materials science, chemistry, immunology and vaccinology. His lab collaborates with virologists, immunologists, and clinicians not only to develop synthetic vaccination platforms but also to understand how biomaterials interact with the immune system and continue to develop novel materials and creative tools to tackle multidisciplinary problems in vaccine development and immunotherapy.
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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Substituent-Based Modulation of Self-Assembly and Immunogenicity of Amphipathic Peptides
Das, A., Pramanik, U., Brown, E. M., Liu, C. Y., Gong, H., Fascetti, J., Gibson, M., Stealey, S., Zustiak, S. P., Berkland, C., Sharma, P., Jackrel, M. E., White, M. A. & Rudra, J. S., Mar 27 2026, In: Advanced Science. 13, 18, e18567.Research output: Contribution to journal › Article › peer-review
Open Access -
Histidine-rich enantiomeric peptide coacervates enhance antigen sequestration and presentation to T cells
Pramanik, U., Das, A., Brown, E. M., Struckman, H. L., Wang, H., Stealey, S., Sprunger, M. L., Wasim, A., Fascetti, J., Mondal, J., Silva, J. R., Zustiak, S. P., Jackrel, M. E. & Rudra, J. S., Mar 25 2025, In: Chemical Science. 16, 17, p. 7523-7536 14 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Link opens in a new tab Scopus citations -
Modulating Peptide Self-Assembly via Triblock Chiral Patterning
O'Neill, C. L., Fascetti, J. L., Clapacs, Z., Kaplita, L. K., Liu, C. Y., Kim, D., White, M. A. & Rudra, J. S., Jul 2 2025, In: Chemistry - A European Journal. 31, 37, e202404603.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations -
Protein structure and bioactivity upon adsorption and desorption from nanosilicate sustained release delivery devices
Stealey, S., Dharmesh, E., Gaharwar, A. K., Rudra, J. S. & Zustiak, S. P., May 13 2025, In: Nanoscale. 17, 21, p. 13477-13488 12 p.Research output: Contribution to journal › Article › peer-review
1 Link opens in a new tab Scopus citations -
6D single-fluorogen orientation-localization microscopy for elucidating the architecture of beta-sheet assemblies and biomolecular condensates
Wu, T., Zhou, W., Rudra, J. S., Pappu, R. V. & Lew, M. D., 2024, High-Speed Biomedical Imaging and Spectroscopy IX. Tsia, K. K. & Goda, K. (eds.). SPIE, 1285302. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 12853).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review