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Personal profile

Research interests

The goal of my research is to optimize allogeneic hematopoietic stem cell transplantation (allo-HSCT ) for the treatment of hematopoietic malignancies. The current clinical goal in allo-HSCT is to separate graft-versus-host disease (GvHD), a life-threatening complication, from a beneficial graft-versus-leukemia effect (GvL) following allo-HSCT. My primary research interest is to understand the role of IFNGR and IL6R signaling and downstream JAK-STAT in GvHD and GvL using mouse models. These include T cell trafficking to GVHD target organs, regulation of regulatory T cells, and the novel GvHD suppressor molecules, S100A8 and S100A9, downstream of IFNGR and IL6R. My research also focuses on developing novel therapeutic strategies for GvHD by targeting IFNGR, IL6R, and/or JAK-STAT.

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Research Output

A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease

Schroeder, M. A., Jean Khoury, H., Jagasia, M., Ali, H., Schiller, G. J., Staser, K., Choi, J., Gehrs, L., Arbushites, M. C., Yan, Y., Langmuir, P., Srinivas, N., Pratta, M., Perales, M. A., Chen, Y. B., Meyers, G. & DiPersio, J. F., Apr 28 2020, In : Blood Advances. 4, 8, p. 1657-1669 13 p.

Research output: Contribution to journalArticle

Open Access
  • 3 Scopus citations

    Selective targeting of α4β1 integrin attenuates murine graft versus host disease

    Alahmari, B., Cooper, M. L., Vij, K., Ritchey, J., Ruminski, P., Gao, F., Choi, J. & DiPersio, J. F., 2020, (Accepted/In press) In : Leukemia.

    Research output: Contribution to journalLetter

    Targeting histone deacetylases to modulate graft-versus-host disease and graft-versus-leukemia

    Kim, S., Santhanam, S., Lim, S. & Choi, J., Jun 2 2020, In : International journal of molecular sciences. 21, 12, p. 1-20 20 p., 4281.

    Research output: Contribution to journalReview article

    Open Access
  • An “off-the-shelf” fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies

    Cooper, M. L., Choi, J., Staser, K., Ritchey, J. K., Devenport, J. M., Eckardt, K., Rettig, M., Wang, B., Eissenberg, L., Ghobadi, A., Gehrs, L. N., Prior, J. L., Achilefu, S., Miller, C., Fronick, C. C., O’Neal, J., Gao, F., Weinstock, D. M., Gutierrez, A., Fulton, R. & 1 others, Dipersio, J., Sep 1 2018, In : Leukemia. 32, 9, p. 1970-1983 14 p.

    Research output: Contribution to journalArticle

  • 72 Scopus citations

    Baricitinib-induced blockade of interferon gamma receptor and interleukin-6 receptor for the prevention and treatment of graft-versus-host disease

    Choi, J., Cooper, M. L., Staser, K., Ashami, K., Vij, K. R., Wang, B., Marsala, L., Niswonger, J., Ritchey, J., Alahmari, B., Achilefu, S., Tsunoda, I., Schroeder, M. A. & DiPersio, J. F., Nov 1 2018, In : Leukemia. 32, 11, p. 2483-2494 12 p.

    Research output: Contribution to journalArticle

  • 20 Scopus citations