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Research interests

The goal of my research is to optimize allogeneic hematopoietic stem cell transplantation (allo-HSCT ) for the treatment of hematopoietic malignancies. The current clinical goal in allo-HSCT is to separate graft-versus-host disease (GvHD), a life-threatening complication, from a beneficial graft-versus-leukemia effect (GvL) following allo-HSCT. My primary research interest is to understand the role of IFNGR and IL6R signaling and downstream JAK-STAT in GvHD and GvL using mouse models. These include T cell trafficking to GVHD target organs, regulation of regulatory T cells, and the novel GvHD suppressor molecules, S100A8 and S100A9, downstream of IFNGR and IL6R. My research also focuses on developing novel therapeutic strategies for GvHD by targeting IFNGR, IL6R, and/or JAK-STAT.


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