Research output per year
Research output per year
- 1 - 50 out of 174 results
Search results
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2014
Effect of single-chain ovine gonadotropins with dual activity on ovarian function in sheep
Rutigliano, H. M., Adams, B. M., Jablonka-Shariff, A., Boime, I. & Adams, T. E., Aug 1 2014, In: Reproduction. 148, 2, p. 129-136 8 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Effect of time and dose of recombinant follicle stimulating hormone agonist on the superovulatory response of sheep
Rutigliano, H. M., Adams, B. M., Jablonka-Shariff, A., Boime, I. & Adams, T. E., Aug 2014, In: Theriogenology. 82, 3, p. 455-460 6 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice
Wang, H., Larson, M., Jablonka-Shariff, A., Pearl, C. A., Miller, W. L., Conn, P. M., Boime, I. & Kumar, T. R., Apr 15 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 15, p. 5735-5740 6 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
2013
A Novel Carboxyl-Terminal Heptapeptide Initiates the Regulated Secretion of LH from Unique Sub-Domains of the ER
Jablonka-Shariff, A. & Boime, I., May 29 2013, In: PloS one. 8, 5, e65002.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2011
A dileucine determinant in the carboxyl terminal sequence of the LHβ subunit is implicated in the regulated secretion of lutropin from transfected GH3 cells
Jablonka-Shariff, A. & Boime, I., Jun 6 2011, In: Molecular and Cellular Endocrinology. 339, 1-2, p. 7-13 7 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
2010
Rerouting of a follicle-stimulating hormone analog to the regulated secretory pathway
Pearl, C. A., Jablonka-Shariff, A. & Boime, I., Jan 2010, In: Endocrinology. 151, 1, p. 388-393 6 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
2009
Advances in recombinant DNA technology: Corifollitropin alfa, a hybrid molecule with sustained follicle-stimulating activity and reduced injection frequency
Fauser, B. C. J. M., Mannaerts, M. J. L., Devroey, P., Leader, A., Boime, I. & Baird, D. T., 2009, In: Human Reproduction Update. 15, 3, p. 309-321 13 p.Research output: Contribution to journal › Article › peer-review
Open Access125 Scopus citations -
Secretory trafficking signal encoded in the carboxyl-terminal region of the CGβ-subunit
Jablonka-Shariff, A. & Boime, I., Mar 2009, In: Molecular Endocrinology. 23, 3, p. 316-323 8 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Sulfation of LH does not affect intracellular trafficking
Pearl, C. A. & Boime, I., Oct 15 2009, In: Molecular and Cellular Endocrinology. 309, 1-2, p. 76-81 6 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
The efficacy of recombinant equine follicle stimulating hormone (reFSH) to promote follicular growth in mares using a follicular suppression model
Jennings, M. W., Boime, I., Daphna-Iken, D., Jablonka-Shariff, A., Conley, A. J., Colgin, M., Bidstrup, L. A., Meyers-Brown, G. A., Famula, T. R. & Roser, J. F., Dec 2009, In: Animal Reproduction Science. 116, 3-4, p. 291-307 17 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
2008
A carboxyl-terminal sequence in the lutropin β subunit contributes to the sorting of lutropin to the regulated pathway
Jablonka-Shariff, A., Pearl, C. A., Comstock, A. & Boime, I., Apr 25 2008, In: Journal of Biological Chemistry. 283, 17, p. 11485-11492 8 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Single-chain human gonadotropin analogs induce follicle development in sheep
Lemke, E. P., Adams, B. M., Jablonka-Shariff, A., Boime, I. & Adams, T. E., Mar 2008, In: Journal of Endocrinology. 196, 3, p. 593-600 8 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
The Expanding Role of Recombinant Gonadotropins in Assisted Reproduction
Adams, T. E. & Boime, I., Jul 1 2008, In: Reproduction in Domestic Animals. 43, SUPPL.2, p. 186-192 7 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
2007
Expression and bioactivity of a single chain recombinant equine luteinizing hormone (reLH)
Jablonka-Shariff, A., Roser, J. F., Bousfield, G. R., Wolfe, M. W., Sibley, L. E., Colgin, M. & Boime, I., Jan 15 2007, In: Theriogenology. 67, 2, p. 311-320 10 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
N-linked oligosaccharides direct the differential assembly and secretion of inhibin α- and βA-subunit dimers
Antenos, M., Stemler, M., Boime, I. & Woodruff, T. K., Jul 2007, In: Molecular Endocrinology. 21, 7, p. 1670-1684 15 p.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
The efficacy of a single chain recombinant equine luteinizing hormone (reLH) in mares: Induction of ovulation, hormone profiles, and inter-ovulatory intervals
Yoon, M. J., Boime, I., Colgin, M., Niswender, K. D., King, S. S., Alvarenga, M., Jablonka-Shariff, A., Pearl, C. A. & Roser, J. F., Nov 2007, In: Domestic Animal Endocrinology. 33, 4, p. 470-479 10 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
2006
Single-chain, triple-domain gonadotropin analogs with disulfide bond mutations in the α-subunit elicit dual follitropin and lutropin activities in vivo
Jablonka-Shariff, A., Kumar, T. R., Eklund, J., Comstock, A. & Boime, I., Jun 2006, In: Molecular Endocrinology. 20, 6, p. 1437-1446 10 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
2005
A single-chain tetradomain glycoprotein hormone analog elicits multiple hormone activities in vivo
Garcia-Campayo, V., Boime, I., Ma, X., Daphna-Iken, D. & Kumar, T. R., Feb 2005, In: Biology of reproduction. 72, 2, p. 301-308 8 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Gonadotropin-induced adrenocortical neoplasia in NU/J nude mice
Bielinska, M., Genova, E., Boime, I., Parviainen, H., Kiiveri, S., Leppäluoto, J., Rahman, N., Heikinheimo, M. & Wilson, D. B., Sep 2005, In: Endocrinology. 146, 9, p. 3975-3984 10 p.Research output: Contribution to journal › Article › peer-review
Open Access55 Scopus citations -
2004
A single-chain bifunctional gonadotropin analog is secreted from Chinese hamster ovary cells as two distinct bioactive species
Garcia-Campayo, V., Jablonka-Shariff, A. & Boime, I., Oct 22 2004, In: Journal of Biological Chemistry. 279, 43, p. 44286-44293 8 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Luteinizing Hormone and Follicle-Stimulating Hormone Exhibit Different Secretion Patterns from Cultured Madin-Darby Canine Kidney Cells
Jablonka-Shariff, A. & Boime, I., Mar 2004, In: Biology of reproduction. 70, 3, p. 649-655 7 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Nude mice as a model for gonadotropin-induced adrenocortical neoplasia
Bielinska, M., Genova, E., Boime, I., Parviainen, H., Kiiveri, S., Rahman, N., Leppäluoto, J., Heikinheimo, M. & Wilson, D. B., 2004, In: Endocrine Research. 30, 4, p. 913-917 5 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
2002
Evolution of lutropin to chorionic gonadotropin generates a specific routing signal for apical release in vivo
Jablonka-Shariff, A., Garcia-Campayo, V. & Boime, I., Jan 11 2002, In: Journal of Biological Chemistry. 277, 2, p. 879-882 4 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Thyrotropin, follitropin, and chorionic gonadotropin expressed as a single multifunctional unit reveal remarkable permissiveness in receptor-ligand interactions
Garcia-Campayo, V., Rajendra Kumar, T. & Boime, I., Oct 1 2002, In: Endocrinology. 143, 10, p. 3773-3778 6 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
Unmasking a new recognition signal for O-linked glycosylation in the chorionic gonadotropin β subunit
Garcia-Campayo, V., Sugahara, T. & Boime, I., Aug 30 2002, In: Molecular and Cellular Endocrinology. 194, 1-2, p. 63-70 8 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
2001
Independent activities of FSH and LH structurally confined in a single polypeptide: Selective modification of the relative potencies of the hormones
Garcia-Campayo, V. & Boime, I., 2001, In: Endocrinology. 142, 12, p. 5203-5211 9 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
The Position of the α and β Subunits in a Single Chain Variant of Human Chorionic Gonadotropin Affects the Heterodimeric Interaction of the Subunits and Receptor-binding Epitopes
Ben-Menahem, D., Jablonka-Shariff, A., Hyde, R. K., Pixley, M. R., Srivastava, S., Berger, P. & Boime, I., Aug 10 2001, In: Journal of Biological Chemistry. 276, 32, p. 29871-29879 9 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
2000
Cellular localization of the human chorionic gonadotropin β-subunit in transgenic mouse placenta
Strauss, B. L. & Boime, I., 2000, In: Endocrinology. 141, 1, p. 430-437 8 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Disulfide bond mutations in follicle-stimulating hormone result in uncoupling of biological activity from intracellular behavior
Hiro'oka, T., Maassen, D., Berger, P. & Boime, I., 2000, In: Endocrinology. 141, 12, p. 4751-4756 6 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
1999
Genetic fusion of an α-subunit gene to the follicle-stimulating hormone and chorionic gonadotropin-β subunit genes: Production of a bifunctional protein
Kanda, M., Jablonka-Shariff, A., Sato, A., Pixley, M. R., Bos, E., Hiro'oka, T., Ben-Menahem, D. & Boime, I., 1999, In: Molecular Endocrinology. 13, 11, p. 1873-1881 9 p.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
Glycoprotein hormone structure-function and analog design
Boime, I. & Ben-Menahem, D., Dec 1 1999, In: Recent Progress in Hormone Research. 54, p. 271-289 19 p.Research output: Contribution to journal › Article › peer-review
64 Scopus citations -
Synthesis of multi-subunit domain gonadotropin complexes: A model for α/β heterodimer formation
Ben-Menahem, D., Hyde, R., Pixley, M., Berger, P. & Boime, I., Nov 16 1999, In: Biochemistry. 38, 46, p. 15070-15077 8 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
The biological action of choriogonadotropin is not dependent on the complete native quaternary interactions between the subunits
Jackson, A. M., Berger, P., Pixley, M., Klein, C., Hsueh, A. J. W. & Boime, I., 1999, In: Molecular Endocrinology. 13, 12, p. 2175-2188 14 p.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
Transgenic models to study gonadotropin function: The role of follicle-stimulating hormone in gonadal growth and tumorigenesis
Kumar, T. R., Palapattu, G., Wang, P., Woodruff, T. K., Boime, I., Byrne, M. C. & Matzuk, M. M., 1999, In: Molecular Endocrinology. 13, 6, p. 851-865 15 p.Research output: Contribution to journal › Article › peer-review
Open Access163 Scopus citations -
1998
Conversion of thyrotropin heterodimer to a biologically active single- chain
Fares, F. A., Yamabe, S., Ben-Menahem, D., Pixley, M., Hsueh, A. J. W. & Boime, I., 1998, In: Endocrinology. 139, 5, p. 2459-2464 6 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Dissociation of early folding events from assembly of the human lutropin β-subunit
Muyan, M., Ruddon, R. W., Norton, S. E., Boime, I. & Bedows, E., 1998, In: Molecular Endocrinology. 12, 10, p. 1640-1649 10 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Maternal-fetal tolerance is maintained despite transgene-driven trophoblast expression of MHC class I, and defects in Fas and its ligand
Rogers, A. M., Boime, I., Connolly, J., Cook, J. R. & Russell, J. H., Nov 1998, In: European Journal of Immunology. 28, 11, p. 3479-3487 9 p.Research output: Contribution to journal › Article › peer-review
60 Scopus citations -
The carboxyl-terminal region is a determinant for the intracellular behavior of the chorionic gonadotropin β subunit: Effects on the processing of the Asn-linked oligosaccharides
Muyan, M. & Boime, I., Dec 1 1998, In: Molecular Endocrinology. 12, 5, p. 766-772 7 p.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
1997
Alteration of N-linked oligosaccharide structures of human chorionic gonadotropin β-subunit by disruption of disulfide bonds
Moriwaki, T., Suganuma, N., Furuhashi, M., Kikkawa, F., Tomoda, Y., Boime, I., Nakata, M. & Mizuochi, T., 1997, In: Glycoconjugate Journal. 14, 2, p. 225-229 5 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
CTP extended form of glycoprotein hormones
Boime, I., 1997, In: Biotechnology Advances. 15, 3-4, p. 768 1 p.Research output: Contribution to journal › Article › peer-review
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Cystine knot of the gonadotropin α subunit is critical for intracellular behavior but not for in vitro biological activity
Sato, A., Perlas, E., Ben-Menahem, D., Kudo, M., Pixley, M. R., Furuhashi, M., Hsueh, A. J. W. & Boime, I., Jul 18 1997, In: Journal of Biological Chemistry. 272, 29, p. 18098-18103 6 p.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
Design of stable biologically active recombinant lutropin analogs
Garcia-Campayo, V., Sato, A., Hirsch, B., Sugahara, T., Muyan, M., Hsueh, A. J. W. & Boime, I., Jul 1997, In: Nature Biotechnology. 15, 7, p. 663-667 5 p.Research output: Contribution to journal › Article › peer-review
44 Scopus citations -
Secretion of chorionic gonadotropin from human trophoblasts
Muyan, M. & Boime, I., 1997, In: Placenta. 18, 4, p. 237-241 5 p.Research output: Contribution to journal › Article › peer-review
61 Scopus citations -
The biologic action of single-chain choriogonadotropin is not dependent on the individual disulfide bonds of the β subunit
Ben-Menahem, D., Kudo, M., Pixley, M. R., Sato, A., Suganuma, N., Perlas, E., Hsueh, A. J. W. & Boime, I., Mar 14 1997, In: Journal of Biological Chemistry. 272, 11, p. 6827-6830 4 p.Research output: Contribution to journal › Article › peer-review
Open Access40 Scopus citations -
1996
Characterization of the O-glycosylation sites in the chorionic gonadotropin β subunit in vivo using site-directed mutagenesis and gene transfer
Sugahara, T., Pixley, M. R., Fares, F. & Boime, I., 1996, In: Journal of Biological Chemistry. 271, 34, p. 20797-20804 8 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Expression of biologically active fusion genes encoding the common or subunit and either the CGβ or FSHβ subunits: Role of a linker sequence
Sugahara, T., Grootenhuis, P. D. J., Sato, A., Kudo, M., Ben-Menahem, D., Pixley, M. R., Hsueh, A. J. W. & Boime, I., Dec 20 1996, In: Molecular and Cellular Endocrinology. 125, 1-2, p. 71-77 7 p.Research output: Contribution to journal › Article › peer-review
40 Scopus citations -
Expression of biologically active fusion genes encoding the common α subunit and the follicle-stimulating hormone β subunit: Role of a linker sequence
Sugahara, T., Sato, A., Rudolf, M., Ben-Menahem, D., Pixley, M. R., Hsueh, A. J. W. & Boime, I., 1996, In: Journal of Biological Chemistry. 271, 18, p. 10445-10448 4 p.Research output: Contribution to journal › Article › peer-review
Open Access71 Scopus citations -
The carboxy-terminal region of the β-subunits of luteinizing hormone and chorionic gonadotropin differentially influence secretion and assembly of the heterodimers
Muyan, M., Furuhashi, M., Sugahara, T. & Boime, I., Dec 17 1996, In: Molecular Endocrinology. 10, 12, p. 1678-1687 10 p.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
1995
Biosynthesis of a biologically active single peptide chain containing the human common α and chorionic gonadotropin β subunits in tandem
Sugahara, T., Pixley, M. R., Minami, S., Perlas, E., Ben-Menahem, D., Hsueh, A. J. W. & Boime, I., 1995, In: Proceedings of the National Academy of Sciences of the United States of America. 92, 6, p. 2041-2045 5 p.Research output: Contribution to journal › Article › peer-review
Open Access111 Scopus citations -
Fusing the carboxy-terminal peptide of the chorionic gonadotropin (CG) beta-subunit to the common alpha-subunit: Retention of O-linked glycosylation and enhanced in vivo bioactivity of chimeric human CG
Furuhashi, M., Shikone, T., Fares, F. A., Sugahara, T., Hsueh, A. J. W. & Boime, I., Jan 1995, In: Molecular Endocrinology. 9, 1, p. 54-63 10 p.Research output: Contribution to journal › Article › peer-review
Open Access56 Scopus citations