Irving Boime

Professor of Developmental Biology, Professor of Reproductive Biology in Obstetrics and Gynecology

    • 6573 Citations
    1967 …2014

    Research output per year

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    Personal profile

    Research interests

    Human chorionic gonadotropin (CG), lutropin (LH), follitropin (FSH), and thyrotropin (TSH) are a family of heterodimeric glycoprotein hormones that share a common α subunit but differ in their hormone-specific β subunits. One or more of these hormones is essential for gonadal development, and for maintaining pregnancy and thyroid function. Using site-directed mutagenesis, our laboratory investigates structural determinants that govern the unique post-translational modifications of the related placental and pituitary glycoprotein hormones. These hormones undergo specific modifications and have unique biologic activities. Together with DNA mediated transfection techniques, monoclonal antibody screening, and protein and carbohydrate characterization, the laboratory is examining the regions critical for chaperone interactions in the folding and the differential sorting of these heterodimeric hormones. Studies are also underway for determining the ligand determinants that are responsible for the transducing signals in the hormone-receptor complex. A critical feature of these hormones is their unique secretion patterns. LH is secreted through a regulated secretory pathway, i.e. it is released by secretagogue, whereas FSH is primarily secreted constitutively. The oligosaccharides on these glycoproteins are hormone specific. We are currently testing models addressing the hypothesis that the carbohydrates play a critical role in FSH/LH sorting. FSH-LH β chimeras and point mutants are currently designed to identify sequences that govern their unique secretion patterns. Informative LH and FSH variants in cell-culture assays will be expressed in pituitaries from transgenic mice. The ability to reroute FSH and LH in vivo would represent an important model for gonadal dysfunction and potentially provide a novel way to examine normal and ultimately pathophysiological events in the human reproductive tract.

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    Research Output

    • 6573 Citations
    • 174 Article
    • 3 Review article
    • 2 Comment/debate
    • 1 Short survey

    Effect of single-chain ovine gonadotropins with dual activity on ovarian function in sheep

    Rutigliano, H. M., Adams, B. M., Jablonka-Shariff, A., Boime, I. & Adams, T. E., Aug 1 2014, In : Reproduction. 148, 2, p. 129-136 8 p.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations

    Effect of time and dose of recombinant follicle stimulating hormone agonist on the superovulatory response of sheep

    Rutigliano, H. M., Adams, B. M., Jablonka-Shariff, A., Boime, I. & Adams, T. E., Aug 2014, In : Theriogenology. 82, 3, p. 455-460 6 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice

    Wang, H., Larson, M., Jablonka-Shariff, A., Pearl, C. A., Miller, W. L., Conn, P. M., Boime, I. & Kumar, T. R., Apr 15 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 15, p. 5735-5740 6 p.

    Research output: Contribution to journalArticle

    Open Access
  • 28 Scopus citations

    A Novel Carboxyl-Terminal Heptapeptide Initiates the Regulated Secretion of LH from Unique Sub-Domains of the ER

    Jablonka-Shariff, A. & Boime, I., May 29 2013, In : PloS one. 8, 5, e65002.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations
  • 5 Scopus citations