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Research interests

Our laboratory is focused on the role of lipid metabolism pathways in the regulation of energy homeostasis. We are particularly interested in how the multifunctional organelles called peroxisomes channel lipids to discrete subcellular compartments to influence metabolism. Peroxisomes are closely associated with lipid droplets and mitochondria. Their ability to carry out fatty acid oxidation and lipid synthesis, especially the production of ether-linked phospholipids, may be critical for generating cellular signals required for normal physiology. We have developed several new mouse models to study various aspects of peroxisome biology, including peroxisomal biogenesis, fatty acid oxidation, and ether lipid synthesis. We are interested in the physiological roles of these processes in various metabolic organs, such as adipose tissue, pancreatic islets, liver, and skeletal muscle. The major focus is on the role of peroxisomes in adipose tissue.

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Research Output

Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation

He, A., Chen, X., Tan, M., Chen, Y., Lu, D., Zhang, X., Dean, J. M., Razani, B. & Lodhi, I. J., Jul 2 2020, In : Molecular cell. 79, 1, p. 30-42.e4

Research output: Contribution to journalArticle

  • 1 Scopus citations

    Alternative splicing of UCP1 by non-cell-autonomous action of PEMT

    Johnson, J. M., Verkerke, A. R. P., Maschek, J. A., Ferrara, P. J., Lin, C. T., Kew, K. A., Neufer, P. D., Lodhi, I. J., Cox, J. E. & Funai, K., Jan 2020, In : Molecular Metabolism. 31, p. 55-66 12 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Author Correction: High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy (Nature Metabolism, (2020), 2, 1, (110-125), 10.1038/s42255-019-0162-4)

    Zhang, X., Sergin, I., Evans, T. D., Jeong, S. J., Rodriguez-Velez, A., Kapoor, D., Chen, S., Song, E., Holloway, K. B., Crowley, J. R., Epelman, S., Weihl, C. C., Diwan, A., Fan, D., Mittendorfer, B., Stitziel, N. O., Schilling, J. D., Lodhi, I. J. & Razani, B., Sep 1 2020, In : Nature Metabolism. 2, 9, p. 991 1 p.

    Research output: Contribution to journalComment/debate

    Open Access
  • Hepatic Peroxisomal β-Oxidation Suppresses Lipophagy via RPTOR Acetylation and MTOR Activation

    He, A., Dean, J. M., Lu, D., Chen, Y. & Lodhi, I. J., 2020, In : Autophagy.

    Research output: Contribution to journalArticle

  • High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy

    Zhang, X., Sergin, I., Evans, T. D., Jeong, S. J., Rodriguez-Velez, A., Kapoor, D., Chen, S., Song, E., Holloway, K. B., Crowley, J. R., Epelman, S., Weihl, C. C., Diwan, A., Fan, D., Mittendorfer, B., Stitziel, N. O., Schilling, J. D., Lodhi, I. J. & Razani, B., Jan 1 2020, In : Nature Metabolism. 2, 1, p. 110-125 16 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations