Our research promotes a better understanding of ‘brain in action’ by elucidating the complex interplay between oxygenation, blood flow, microvascular structure, and metabolism in health and disease. We conduct in vivo optical imaging across scales in spatial (subcapillary to whole-brain) and temporal (milliseconds to months) domains. These preclinical optical measurements inform a quantitative interpretation of the human neuroimaging signals (such as BOLD fMRI) and support the efforts towards bridging across imaging modalities. In addition to the cerebral energetics, we investigate the projections of brain health into other organs such as the eye and the gut to identify the early markers of neurovascular diseases and preventative strategies.

keywords: optical microscopy, neuroimaging, biomedical optics, biophotonics, preclinical imaging, oxygenation, blood flow, neurovascular coupling, brain, retina, gut, cilia 

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I am interested in mentoring students (Ph.D., Post-Baccalaureate, and undergraduate) and postdoctoral fellows. Feel free to contact me if you want to join our team for interdisciplinary preclinical research.