Igor Smirnov

Research output

Research output per year 2001 2014 2015 2018 2020 2021 2023 2023

• 35 Article
• 3 Comment/debate
• 1 Letter
• 1 Review article

Research output per year

Research output per year

Search results

• 2023

  Age-dependent immune and lymphatic responses after spinal cord injury

  Salvador, A. F. M., Dykstra, T., Rustenhoven, J., Gao, W., Blackburn, S. M., Bhasiin, K., Dong, M. Q., Guimarães, R. M., Gonuguntla, S., Smirnov, I., Kipnis, J. & Herz, J., Jul 19 2023, In: Neuron. 111, 14, p. 2155-2169.e9

  Research output: Contribution to journal › Article › peer-review

  • Spinal Cord Injuries 100%
  • Spinal Cord 68%
  • Meninges 53%
  • Myeloid Cells 42%
  • Microglia 21%
  2 Scopus citations

• Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage

  Rustenhoven, J., Pavlou, G., Storck, S. E., Dykstra, T., Du, S., Wan, Z., Quintero, D., Scallan, J. P., Smirnov, I., Kamm, R. D. & Kipnis, J., Jul 3 2023, In: Journal of Experimental Medicine. 220, 7, e20221929.

  Research output: Contribution to journal › Article › peer-review

  • Drive 100%
  • Drainage 82%
  • Cerebrospinal Fluid Leak 80%
  • Immunity 79%
  • Central Nervous System 71%
  2 Scopus citations

• Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy

  Chen, X., Firulyova, M., Manis, M., Herz, J., Smirnov, I., Aladyeva, E., Wang, C., Bao, X., Finn, M. B., Hu, H., Shchukina, I., Kim, M. W., Yuede, C. M., Kipnis, J., Artyomov, M. N., Ulrich, J. D. & Holtzman, D. M., Mar 23 2023, In: Nature. 615, 7953, p. 668-677 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Tauopathies 100%
  • Drive 76%
  • Microglia 74%
  • Amyloid 69%
  • T-Lymphocytes 45%
  49 Scopus citations
• 2022

  Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels

  Mazzitelli, J. A., Smyth, L. C. D., Cross, K. A., Dykstra, T., Sun, J., Du, S., Mamuladze, T., Smirnov, I., Rustenhoven, J. & Kipnis, J., May 2022, In: Nature neuroscience. 25, 5, p. 555-560 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Skull 100%
  • Cerebrospinal Fluid 88%
  • Meninges 87%
  • Bone Marrow 74%
  • Myelopoiesis 48%
  71 Scopus citations

• Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

  Dominantly Inherited Alzheimer Network, Nov 17 2022, In: Nature. 611, 7936, p. 585-593 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cerebrospinal Fluid 100%
  • Macrophages 80%
  • Hydrodynamics 39%
  • Alzheimer Disease 26%
  • Central Nervous System 25%
  47 Scopus citations
• 2021

  ELMO1 signaling is a promoter of osteoclast function and bone loss

  Arandjelovic, S., Perry, J. S. A., Zhou, M., Ceroi, A., Smirnov, I., Walk, S. F., Shankman, L. S., Cambré, I., Onengut-Gumuscu, S., Elewaut, D., Conrads, T. P. & Ravichandran, K. S., Dec 1 2021, In: Nature communications. 12, 1, 4974.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Osteoclasts 100%
  • bones 94%
  • Bone and Bones 57%
  • arthritis 44%
  • osteoporosis 41%
  15 Scopus citations

• Functional characterization of the dural sinuses as a neuroimmune interface

  Rustenhoven, J., Drieu, A., Mamuladze, T., de Lima, K. A., Dykstra, T., Wall, M., Papadopoulos, Z., Kanamori, M., Salvador, A. F., Baker, W., Lemieux, M., Da Mesquita, S., Cugurra, A., Fitzpatrick, J., Sviben, S., Kossina, R., Bayguinov, P., Townsend, R. R., Zhang, Q., Erdmann-Gilmore, P., & 4 othersSmirnov, I., Lopes, M. B., Herz, J. & Kipnis, J., Feb 18 2021, In: Cell. 184, 4, p. 1000-1016.e27

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Antigen 100%
  • Central Nervous System 88%
  • Antigens 75%
  • Cerebrospinal Fluid 52%
  • Immune Privilege 44%
  235 Scopus citations

• GABAergic neuronal IL-4R mediates T cell effect on memory

  Herz, J., Fu, Z., Kim, K., Dykstra, T., Wall, M., Li, H., Salvador, A. F., Zou, B., Yan, N., Blackburn, S. M., Andrews, P. H., Goldman, D. H., Papadopoulos, Z., Smirnov, I., Xie, X. S. & Kipnis, J., Nov 17 2021, In: Neuron. 109, 22, p. 3609-3618.e9

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Memory 100%
  • Small Nuclear RNA 99%
  • T-Lymphocytes 84%
  • Neurons 84%
  • Interleukin-4 63%
  34 Scopus citations

• Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders

  Brioschi, S., Wang, W. L., Peng, V., Wang, M., Shchukina, I., Greenberg, Z. J., Bando, J. K., Jaeger, N., Czepielewski, R. S., Swain, A., Mogilenko, D. A., Beatty, W. L., Bayguinov, P., Fitzpatrick, J. A. J., Schuettpelz, L. G., Fronick, C. C., Smirnov, I., Kipnis, J., Shapiro, V. S., Wu, G. F., & 5 othersGilfillan, S., Cella, M., Artyomov, M. N., Kleinstein, S. H. & Colonna, M., Jul 23 2021, In: Science. 373, 6553, eabf9277.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • B-Lymphocytes 100%
  • Central Nervous System 96%
  • Meninges 83%
  • Skull 42%
  • Parabiosis 35%
  179 Scopus citations

• Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

  Dominantly Inherited Alzheimer Network, Herz, J., Smirnov, I., Benitez, B. A., Karch, C. M., Perrin, R. J., Holtzman, D. M., Cruchaga, C., Harari, O. & Kipnis, J., May 13 2021, In: Nature. 593, 7858, p. 255-260 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Microglia 100%
  • Immunotherapy 86%
  • Alzheimer Disease 76%
  • Passive Immunization 39%
  • Amyloid 31%
  125 Scopus citations

• Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma

  Cugurra, A., Mamuladze, T., Rustenhoven, J., Dykstra, T., Beroshvili, G., Greenberg, Z. J., Baker, W., Papadopoulos, Z., Drieu, A., Blackburn, S., Kanamori, M., Brioschi, S., Herz, J., Schuettpelz, L. G., Colonna, M., Smirnov, I. & Kipnis, J., Jul 23 2021, In: Science. 373, 6553, eabf7844.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Meninges 100%
  • Myeloid Cells 79%
  • Skull 76%
  • Bone Marrow Cells 73%
  • Central Nervous System 57%
  230 Scopus citations
• 2020

  Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling

  Still, K. M., Batista, S. J., O'Brien, C. A., Oyesola, O. O., Früh, S. P., Webb, L. M., Smirnov, I., Kovacs, M. A., Cowan, M. N., Hayes, N. W., Thompson, J. A., Wojno, E. D. T. & Harris, T. H., Oct 27 2020, In: PLoS pathogens. 16, 10, e1009027.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interleukin-33 100%
  • astrocytes 88%
  • Toxoplasmosis 85%
  • Toxoplasma gondii 83%
  • Astrocytes 67%
  22 Scopus citations

• Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis

  Bolte, A. C., Dutta, A. B., Hurt, M. E., Smirnov, I., Kovacs, M. A., McKee, C. A., Ennerfelt, H. E., Shapiro, D., Nguyen, B. H., Frost, E. L., Lammert, C. R., Kipnis, J. & Lukens, J. R., Dec 1 2020, In: Nature communications. 11, 1, 4524.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • brain damage 100%
  • Intracranial 97%
  • pathogenesis 95%
  • Traumatic Brain Injury 60%
  • Pressure 35%
  132 Scopus citations

• Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons

  Alves de Lima, K., Rustenhoven, J., Da Mesquita, S., Wall, M., Salvador, A. F., Smirnov, I., Martelossi Cebinelli, G., Mamuladze, T., Baker, W., Papadopoulos, Z., Lopes, M. B., Cao, W. S., Xie, X. S., Herz, J. & Kipnis, J., Nov 1 2020, In: Nature immunology. 21, 11, p. 1421-1429 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-17 100%
  • Anxiety 67%
  • T-Lymphocytes 58%
  • Neurons 58%
  • Vertebrates 28%
  178 Scopus citations
• 2018

  CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature

  Louveau, A., Herz, J., Alme, M. N., Salvador, A. F., Dong, M. Q., Viar, K. E., Herod, S. G., Knopp, J., Setliff, J. C., Lupi, A. L., Da Mesquita, S., Frost, E. L., Gaultier, A., Harris, T. H., Cao, R., Hu, S., Lukens, J. R., Smirnov, I., Overall, C. C., Oliver, G., & 1 othersKipnis, J., Oct 1 2018, In: Nature neuroscience. 21, 10, p. 1380-1391 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Drainage 100%
  • T-Lymphocytes 72%
  • Multiple Sclerosis 69%
  • Meninges 50%
  • Cerebrospinal Fluid Leak 48%
  466 Scopus citations

• Erratum to: Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease (Nature, (2018), 560, 7717, (185-191), 10.1038/s41586-018-0368-8)

  Da Mesquita, S., Louveau, A., Vaccari, A., Smirnov, I., Cornelison, R. C., Kingsmore, K. M., Contarino, C., Onengut-Gumuscu, S., Farber, E., Raper, D., Viar, K. E., Powell, R. D., Baker, W., Dabhi, N., Bai, R., Cao, R., Hu, S., Rich, S. S., Munson, J. M., Lopes, M. B., & 3 othersOverall, C. C., Acton, S. T. & Kipnis, J., Dec 6 2018, In: Nature. 564, 7734, p. E7

  Research output: Contribution to journal › Comment/debate

  Open Access

  • Alzheimer Disease 100%
  • History 96%
  5 Scopus citations

• Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

  Da Mesquita, S., Louveau, A., Vaccari, A., Smirnov, I., Cornelison, R. C., Kingsmore, K. M., Contarino, C., Onengut-Gumuscu, S., Farber, E., Raper, D., Viar, K. E., Powell, R. D., Baker, W., Dabhi, N., Bai, R., Cao, R., Hu, S., Rich, S. S., Munson, J. M., Lopes, M. B., & 3 othersOverall, C. C., Acton, S. T. & Kipnis, J., Aug 9 2018, In: Nature. 560, 7717, p. 185-191 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Glymphatic System 100%
  • Alzheimer Disease 49%
  • Extracellular Fluid 47%
  • Central Nervous System 46%
  • mouse vascular endothelial growth factor C 44%
  655 Scopus citations

• Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury

  Norris, G. T., Smirnov, I., Filiano, A. J., Shadowen, H. M., Cody, K. R., Thompson, J. A., Harris, T. H., Gaultier, A., Overall, C. C. & Kipnis, J., Jul 1 2018, In: Journal of Experimental Medicine. 215, 7, p. 1789-1801 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microglia 100%
  • Wounds and Injuries 47%
  • Phagocytosis 41%
  • Geniculate Bodies 34%
  • Myeloid Cells 28%
  68 Scopus citations

• Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia

  Cronk, J. C., Filiano, A. J., Louveau, A., Marin, I., Marsh, R., Ji, E., Goldman, D. H., Smirnov, I., Geraci, N., Acton, S., Overall, C. C. & Kipnis, J., Jun 1 2018, In: Journal of Experimental Medicine. 215, 6, p. 1627-1647 21 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microglia 100%
  • Macrophages 68%
  • Brain 48%
  • Central Nervous System 16%
  • Bone Marrow Transplantation 11%
  241 Scopus citations
• 2017

  Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury

  Gadani, S. P., Smirnov, I., Smith, A. T., Overall, C. C. & Kipnis, J., 2017, In: Journal of Experimental Medicine. 214, 2, p. 285-296 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nervous System Trauma 100%
  • Spinal Cord Injuries 77%
  • Meninges 69%
  • Central Nervous System 59%
  • Lymphocytes 56%
  87 Scopus citations

• Influenza A induces dysfunctional immunity and death in MeCP2-overexpressing mice

  Cronk, J. C., Herz, J., Kim, T. S., Louveau, A., Moser, E. K., Sharma, A. K., Smirnov, I., Tung, K. S., Braciale, T. J. & Kipnis, J., Jan 26 2017, In: JCI Insight. 2, 2, e88257.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mouse Mecp2 protein 100%
  • Methyl-CpG-Binding Protein 2 78%
  • Human Influenza 47%
  • Immunity 42%
  • Rett Syndrome 20%
  8 Scopus citations
• 2016

  Erratum: Structural and functional features of central nervous system lymphatic vessels (Nature (2015) 523 (337-341) Doi:10.1038/nature14432)

  Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., Harris, T. H. & Kipnis, J., Feb 24 2016, In: Nature. 533, p. 278 1 p.

  Research output: Contribution to journal › Comment/debate

  Open Access
  14 Scopus citations

• Unexpected role of interferon-γ 3 in regulating neuronal connectivity and social behaviour

  Filiano, A. J., Xu, Y., Tustison, N. J., Marsh, R. L., Baker, W., Smirnov, I., Overall, C. C., Gadani, S. P., Turner, S. D., Weng, Z., Peerzade, S. N., Chen, H., Lee, K. S., Scott, M. M., Beenhakker, M. P., Litvak, V. & Kipnis, J., Jul 13 2016, In: Nature. 535, 7612, p. 425-429 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Social Behavior 100%
  • Interferons 78%
  • Immunity 40%
  • Transcriptome 33%
  • 3-aminobutyric acid 23%
  417 Scopus citations
• 2015

  Erratum: MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4 (Journal of Clinical Investigation (2015) 125:2 (699-714) DOI:10.1172/JCI76210)

  Walsh, J. T., Hendrix, S., Boato, F., Smirnov, I., Zheng, J., Lukens, J. R., Gadani, S., Hechler, D., Gölz, G., Rosenberger, K., Kammertöns, T., Vogt, J., Vogelaar, C., Siffrin, V., Radjavi, A., Fernandez-Castaneda, A., Gaultier, A., Gold, R., Kanneganti, T. D., Nitsch, R., & 2 othersZipp, F. & Kipnis, J., Jun 1 2015, In: Journal of Clinical Investigation. 125, 6, p. 2547 1 p.

  Research output: Contribution to journal › Comment/debate

  Open Access
  25 Scopus citations

• Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli

  Cronk, J. C., Derecki, N. C., Ji, E., Xu, Y., Lampano, A. E., Smirnov, I., Baker, W., Norris, G. T., Marin, I., Coddington, N., Wolf, Y., Turner, S. D., Aderem, A., Klibanov, A. L., Harris, T. H., Jung, S., Litvak, V. & Kipnis, J., Apr 21 2015, In: Immunity. 42, 4, p. 679-691 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Methyl-CpG-Binding Protein 2 100%
  • Microglia 67%
  • Rett Syndrome 59%
  • Macrophages 46%
  • Gene Expression 39%
  133 Scopus citations

• MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4

  Walsh, J. T., Hendrix, S., Boato, F., Smirnov, I., Zheng, J., Lukens, J. R., Gadani, S., Hechler, D., Gölz, G., Rosenberger, K., Kammertöns, T., Vogt, J., Vogelaar, C., Siffrin, V., Radjavi, A., Fernandez-Castaneda, A., Gaultier, A., Gold, R., Kanneganti, T. D., Nitsch, R., & 2 othersZipp, F. & Kipnis, J., Feb 2 2015, In: Journal of Clinical Investigation. 125, 2, p. 699-714 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Histocompatibility 100%
  • Interleukin-4 74%
  • T-Lymphocytes 49%
  • Neurons 49%
  • Neuroprotection 48%
  139 Scopus citations

• Structural and functional features of central nervous system lymphatic vessels

  Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., Harris, T. H. & Kipnis, J., Jul 16 2015, In: Nature. 523, 7560, p. 337-341 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Lymphatic Vessels 100%
  • Central Nervous System 61%
  • Lymphatic System 42%
  • Meninges 21%
  • Cerebrospinal Fluid 14%
  2751 Scopus citations

• The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury

  Gadani, S. P., Walsh, J. T., Smirnov, I., Zheng, J. & Kipnis, J., Feb 18 2015, In: Neuron. 85, 4, p. 703-709 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Alarmins 100%
  • Interleukin-33 90%
  • Neuroglia 58%
  • Wounds and Injuries 32%
  • Oligodendroglia 24%
  240 Scopus citations
• 2014

  Brain antigen-reactive CD4⁺ T cells are sufficient to support learning behavior in mice with limited T cell repertoire

  Radjavi, A., Smirnov, I. & Kipnis, J., Jan 2014, In: Brain, Behavior, and Immunity. 35, p. 58-63 6 p.

  Research output: Contribution to journal › Article › peer-review

  • CD4 Antigens 100%
  • Learning 57%
  • T-Lymphocytes 48%
  • Brain 38%
  • Adoptive Transfer 36%
  94 Scopus citations

• Dynamics of the meningeal CD4 + T-cell repertoire are defined by the cervical lymph nodes and facilitate cognitive task performance in mice

  Radjavi, A., Smirnov, I., Derecki, N. & Kipnis, J., May 2014, In: Molecular Psychiatry. 19, 5, p. 531-533 3 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access
  73 Scopus citations

• Regulatory T cells in central nervous system injury: A double-edged sword

  Walsh, J. T., Zheng, J., Smirnov, I., Lorenz, U., Tung, K. & Kipnis, J., Nov 15 2014, In: Journal of Immunology. 193, 10, p. 5013-5022 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nervous System Trauma 100%
  • Regulatory T-Lymphocytes 80%
  • Central Nervous System 59%
  • Wounds and Injuries 39%
  • Lymph Nodes 21%
  63 Scopus citations
• 2013

  Chronic mild stress eliminates the neuroprotective effect of Copaxone after CNS injury

  Smirnov, I., Walsh, J. T. & Kipnis, J., Jul 2013, In: Brain, Behavior, and Immunity. 31, p. 177-182 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Glatiramer Acetate 100%
  • Neuroprotective Agents 69%
  • Wounds and Injuries 33%
  • Multiple Sclerosis 12%
  • Crush Injuries 9%
  7 Scopus citations
• 2012

  Cauda equina repair in the rat: Part 2. Time course of ventral root conduction failure

  Mackenzie, S. J., Smirnov, I. & Calancie, B., May 20 2012, In: Journal of neurotrauma. 29, 8, p. 1683-1690 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Cauda Equina 100%
  • Spinal Nerve Roots 87%
  • Electromyography 37%
  • Wounds and Injuries 36%
  • Tail 35%
  12 Scopus citations
• 2011

  Cell survival or cell death: Differential vulnerability of long descending and thoracic propriospinal neurons to low thoracic axotomy in the adult rat

  Conta Steencken, A. C., Smirnov, I. & Stelzner, D. J., Oct 27 2011, In: Neuroscience. 194, p. 359-371 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Axotomy 100%
  • Cell Survival 57%
  • Cell Death 57%
  • Thorax 51%
  • Neurons 46%
  19 Scopus citations
• 2009

  Cauda equina repair in the rat: Part 1. Stimulus-evoked EMG for identifying spinal nerves innervating intrinsic tail muscles

  Blaskiewicz, D. J., Smirnov, I., Cisu, T., DeRuisseau, L. R., Stelzner, D. J. & Calancie, B., Aug 1 2009, In: Journal of neurotrauma. 26, 8, p. 1405-1416 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Cauda Equina 100%
  • Spinal Nerves 93%
  • Tail 71%
  • Spinal Nerve Roots 52%
  • Muscles 44%
  4 Scopus citations
• 2007

  A novel immune-based therapy for stroke induces neuroprotection and supports neurogenesis

  Ziv, Y., Finkelstein, A., Geffen, Y., Kipnis, J., Smirnov, I., Shpilman, S., Vertkin, I., Kimron, M., Lange, A., Hecht, T., Reyman, K. G., Marder, J. B., Schwartz, M. & Yoles, E., Feb 2007, In: Stroke. 38, 2 PART 2, p. 774-782 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • poly(tyrosyl-glutamic acid) 100%
  • Neurogenesis 56%
  • Neuroprotection 56%
  • Stroke 36%
  • Middle Cerebral Artery Infarction 29%
  60 Scopus citations
• 2006

  Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis

  Butovsky, O., Landa, G., Kunis, G., Ziv, Y., Avidan, H., Greenberg, N., Schwartz, A., Smirnov, I., Pollack, A., Jung, S. & Schwartz, M., Apr 1 2006, In: Journal of Clinical Investigation. 116, 4, p. 905-915 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microglia 100%
  • Multiple Sclerosis 86%
  • Animal Models 71%
  • Insulin-Like Growth Factor I 39%
  • Interleukin-4 36%
  214 Scopus citations
• 2003

  Features of skin-coincubated macrophages that promote recovery from spinal cord injury

  Bomstein, Y., Marder, J. B., Vitner, K., Smirnov, I., Lisaey, G., Butovsky, O., Fulga, V. & Yoles, E., Sep 2003, In: Journal of Neuroimmunology. 142, 1-2, p. 10-16 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinal Cord Injuries 100%
  • Macrophages 72%
  • Skin 57%
  • Spinal Cord 56%
  • Inflammation 40%
  130 Scopus citations

• Vaccination with dendritic cells pulsed with peptides of myelin basic protein promotes functional recovery from spinal cord injury

  Hauben, E., Gothilf, A., Cohen, A., Butovsky, O., Nevo, U., Smirnov, I., Yoles, E., Akselrod, S. & Schwartz, M., Sep 24 2003, In: Journal of Neuroscience. 23, 25, p. 8808-8819 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myelin Basic Protein 100%
  • Spinal Cord Injuries 78%
  • Dendritic Cells 73%
  • Vaccination 65%
  • Peptides 52%
  81 Scopus citations
• 2001

  Posttraumatic therapeutic vaccination with modified myelin self-antigen prevents complete paralysis while avoiding autoimmune disease

  Hauben, E., Agranov, E., Gothilf, A., Nero, U., Cohen, A., Smirnov, I., Steinman, L. & Schwartz, M., 2001, In: Journal of Clinical Investigation. 108, 4, p. 591-599 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Autoantigens 100%
  • Myelin Sheath 93%
  • Paralysis 87%
  • Spinal Cord Injuries 86%
  • Autoimmune Diseases 78%
  184 Scopus citations