Research output per year
Research output per year
- 42 results
Search results
-
2024
Identification of direct connections between the dura and the brain
Smyth, L. C. D., Xu, D., Okar, S. V., Dykstra, T., Rustenhoven, J., Papadopoulos, Z., Bhasiin, K., Kim, M. W., Drieu, A., Mamuladze, T., Blackburn, S., Gu, X., Gaitán, M. I., Nair, G., Storck, S. E., Du, S., White, M. A., Bayguinov, P., Smirnov, I. & Dikranian, K. & 2 others, , Mar 7 2024, In: Nature. 627, 8002, p. 165-173 9 p.Research output: Contribution to journal › Article › peer-review
Open Access40 Scopus citations -
Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance
Jiang-Xie, L. F., Drieu, A., Bhasiin, K., Quintero, D., Smirnov, I. & Kipnis, J., Mar 7 2024, In: Nature. 627, 8002, p. 157-164 8 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
2023
Age-dependent immune and lymphatic responses after spinal cord injury
Salvador, A. F. M., Dykstra, T., Rustenhoven, J., Gao, W., Blackburn, S. M., Bhasiin, K., Dong, M. Q., Guimarães, R. M., Gonuguntla, S., Smirnov, I., Kipnis, J. & Herz, J., Jul 19 2023, In: Neuron. 111, 14, p. 2155-2169.e9Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage
Rustenhoven, J., Pavlou, G., Storck, S. E., Dykstra, T., Du, S., Wan, Z., Quintero, D., Scallan, J. P., Smirnov, I., Kamm, R. D. & Kipnis, J., Jul 3 2023, In: Journal of Experimental Medicine. 220, 7, e20221929.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy
Chen, X., Firulyova, M., Manis, M., Herz, J., Smirnov, I., Aladyeva, E., Wang, C., Bao, X., Finn, M. B., Hu, H., Shchukina, I., Kim, M. W., Yuede, C. M., Kipnis, J., Artyomov, M. N., Ulrich, J. D. & Holtzman, D. M., Mar 23 2023, In: Nature. 615, 7953, p. 668-677 10 p.Research output: Contribution to journal › Article › peer-review
Open Access193 Scopus citations -
2022
Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels
Mazzitelli, J. A., Smyth, L. C. D., Cross, K. A., Dykstra, T., Sun, J., Du, S., Mamuladze, T., Smirnov, I., Rustenhoven, J. & Kipnis, J., May 2022, In: Nature neuroscience. 25, 5, p. 555-560 6 p.Research output: Contribution to journal › Article › peer-review
Open Access115 Scopus citations -
Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid
Dominantly Inherited Alzheimer Network, Nov 17 2022, In: Nature. 611, 7936, p. 585-593 9 p.Research output: Contribution to journal › Article › peer-review
Open Access112 Scopus citations -
2021
ELMO1 signaling is a promoter of osteoclast function and bone loss
Arandjelovic, S., Perry, J. S. A., Zhou, M., Ceroi, A., Smirnov, I., Walk, S. F., Shankman, L. S., Cambré, I., Onengut-Gumuscu, S., Elewaut, D., Conrads, T. P. & Ravichandran, K. S., Dec 1 2021, In: Nature communications. 12, 1, 4974.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Functional characterization of the dural sinuses as a neuroimmune interface
Rustenhoven, J., Drieu, A., Mamuladze, T., de Lima, K. A., Dykstra, T., Wall, M., Papadopoulos, Z., Kanamori, M., Salvador, A. F., Baker, W., Lemieux, M., Da Mesquita, S., Cugurra, A., Fitzpatrick, J., Sviben, S., Kossina, R., Bayguinov, P., Townsend, R. R., Zhang, Q. & Erdmann-Gilmore, P. & 4 others, , Feb 18 2021, In: Cell. 184, 4, p. 1000-1016.e27Research output: Contribution to journal › Article › peer-review
Open Access352 Scopus citations -
GABAergic neuronal IL-4R mediates T cell effect on memory
Herz, J., Fu, Z., Kim, K., Dykstra, T., Wall, M., Li, H., Salvador, A. F., Zou, B., Yan, N., Blackburn, S. M., Andrews, P. H., Goldman, D. H., Papadopoulos, Z., Smirnov, I., Xie, X. S. & Kipnis, J., Nov 17 2021, In: Neuron. 109, 22, p. 3609-3618.e9Research output: Contribution to journal › Article › peer-review
Open Access54 Scopus citations -
Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders
Brioschi, S., Wang, W. L., Peng, V., Wang, M., Shchukina, I., Greenberg, Z. J., Bando, J. K., Jaeger, N., Czepielewski, R. S., Swain, A., Mogilenko, D. A., Beatty, W. L., Bayguinov, P., Fitzpatrick, J. A. J., Schuettpelz, L. G., Fronick, C. C., Smirnov, I., Kipnis, J., Shapiro, V. S. & Wu, G. F. & 5 others, , Jul 23 2021, In: Science. 373, 6553, eabf9277.Research output: Contribution to journal › Article › peer-review
Open Access245 Scopus citations -
Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy
Dominantly Inherited Alzheimer Network, Herz, J., Smirnov, I., Benitez, B. A., Karch, C. M., Perrin, R. J., Holtzman, D. M., Cruchaga, C., Harari, O. & Kipnis, J., May 13 2021, In: Nature. 593, 7858, p. 255-260 6 p.Research output: Contribution to journal › Article › peer-review
Open Access216 Scopus citations -
Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma
Cugurra, A., Mamuladze, T., Rustenhoven, J., Dykstra, T., Beroshvili, G., Greenberg, Z. J., Baker, W., Papadopoulos, Z., Drieu, A., Blackburn, S., Kanamori, M., Brioschi, S., Herz, J., Schuettpelz, L. G., Colonna, M., Smirnov, I. & Kipnis, J., Jul 23 2021, In: Science. 373, 6553, eabf7844.Research output: Contribution to journal › Article › peer-review
Open Access325 Scopus citations -
2020
Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling
Still, K. M., Batista, S. J., O'Brien, C. A., Oyesola, O. O., Früh, S. P., Webb, L. M., Smirnov, I., Kovacs, M. A., Cowan, M. N., Hayes, N. W., Thompson, J. A., Wojno, E. D. T. & Harris, T. H., Oct 27 2020, In: PLoS pathogens. 16, 10, e1009027.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis
Bolte, A. C., Dutta, A. B., Hurt, M. E., Smirnov, I., Kovacs, M. A., McKee, C. A., Ennerfelt, H. E., Shapiro, D., Nguyen, B. H., Frost, E. L., Lammert, C. R., Kipnis, J. & Lukens, J. R., Dec 1 2020, In: Nature communications. 11, 1, 4524.Research output: Contribution to journal › Review article › peer-review
Open Access197 Scopus citations -
Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons
Alves de Lima, K., Rustenhoven, J., Da Mesquita, S., Wall, M., Salvador, A. F., Smirnov, I., Martelossi Cebinelli, G., Mamuladze, T., Baker, W., Papadopoulos, Z., Lopes, M. B., Cao, W. S., Xie, X. S., Herz, J. & Kipnis, J., Nov 1 2020, In: Nature immunology. 21, 11, p. 1421-1429 9 p.Research output: Contribution to journal › Article › peer-review
Open Access230 Scopus citations -
2018
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature
Louveau, A., Herz, J., Alme, M. N., Salvador, A. F., Dong, M. Q., Viar, K. E., Herod, S. G., Knopp, J., Setliff, J. C., Lupi, A. L., Da Mesquita, S., Frost, E. L., Gaultier, A., Harris, T. H., Cao, R., Hu, S., Lukens, J. R., Smirnov, I., Overall, C. C. & Oliver, G. & 1 others, , Oct 1 2018, In: Nature neuroscience. 21, 10, p. 1380-1391 12 p.Research output: Contribution to journal › Article › peer-review
Open Access602 Scopus citations -
Erratum to: Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease (Nature, (2018), 560, 7717, (185-191), 10.1038/s41586-018-0368-8)
Da Mesquita, S., Louveau, A., Vaccari, A., Smirnov, I., Cornelison, R. C., Kingsmore, K. M., Contarino, C., Onengut-Gumuscu, S., Farber, E., Raper, D., Viar, K. E., Powell, R. D., Baker, W., Dabhi, N., Bai, R., Cao, R., Hu, S., Rich, S. S., Munson, J. M. & Lopes, M. B. & 3 others, , Dec 6 2018, In: Nature. 564, 7734, p. E7Research output: Contribution to journal › Comment/debate
Open Access8 Scopus citations -
Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease
Da Mesquita, S., Louveau, A., Vaccari, A., Smirnov, I., Cornelison, R. C., Kingsmore, K. M., Contarino, C., Onengut-Gumuscu, S., Farber, E., Raper, D., Viar, K. E., Powell, R. D., Baker, W., Dabhi, N., Bai, R., Cao, R., Hu, S., Rich, S. S., Munson, J. M. & Lopes, M. B. & 3 others, , Aug 9 2018, In: Nature. 560, 7717, p. 185-191 7 p.Research output: Contribution to journal › Article › peer-review
Open Access860 Scopus citations -
Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury
Norris, G. T., Smirnov, I., Filiano, A. J., Shadowen, H. M., Cody, K. R., Thompson, J. A., Harris, T. H., Gaultier, A., Overall, C. C. & Kipnis, J., Jul 1 2018, In: Journal of Experimental Medicine. 215, 7, p. 1789-1801 13 p.Research output: Contribution to journal › Article › peer-review
Open Access88 Scopus citations -
Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia
Cronk, J. C., Filiano, A. J., Louveau, A., Marin, I., Marsh, R., Ji, E., Goldman, D. H., Smirnov, I., Geraci, N., Acton, S., Overall, C. C. & Kipnis, J., Jun 1 2018, In: Journal of Experimental Medicine. 215, 6, p. 1627-1647 21 p.Research output: Contribution to journal › Article › peer-review
Open Access274 Scopus citations -
2017
Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury
Gadani, S. P., Smirnov, I., Smith, A. T., Overall, C. C. & Kipnis, J., 2017, In: Journal of Experimental Medicine. 214, 2, p. 285-296 12 p.Research output: Contribution to journal › Article › peer-review
Open Access98 Scopus citations -
Influenza A induces dysfunctional immunity and death in MeCP2-overexpressing mice
Cronk, J. C., Herz, J., Kim, T. S., Louveau, A., Moser, E. K., Sharma, A. K., Smirnov, I., Tung, K. S., Braciale, T. J. & Kipnis, J., Jan 26 2017, In: JCI Insight. 2, 2, e88257.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2016
Erratum: Structural and functional features of central nervous system lymphatic vessels (Nature (2015) 523 (337-341) Doi:10.1038/nature14432)
Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., Harris, T. H. & Kipnis, J., Feb 24 2016, In: Nature. 533, p. 278 1 p.Research output: Contribution to journal › Comment/debate
Open Access15 Scopus citations -
Unexpected role of interferon-γ 3 in regulating neuronal connectivity and social behaviour
Filiano, A. J., Xu, Y., Tustison, N. J., Marsh, R. L., Baker, W., Smirnov, I., Overall, C. C., Gadani, S. P., Turner, S. D., Weng, Z., Peerzade, S. N., Chen, H., Lee, K. S., Scott, M. M., Beenhakker, M. P., Litvak, V. & Kipnis, J., Jul 13 2016, In: Nature. 535, 7612, p. 425-429 5 p.Research output: Contribution to journal › Article › peer-review
Open Access494 Scopus citations -
2015
Erratum: MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4 (Journal of Clinical Investigation (2015) 125:2 (699-714) DOI:10.1172/JCI76210)
Walsh, J. T., Hendrix, S., Boato, F., Smirnov, I., Zheng, J., Lukens, J. R., Gadani, S., Hechler, D., Gölz, G., Rosenberger, K., Kammertöns, T., Vogt, J., Vogelaar, C., Siffrin, V., Radjavi, A., Fernandez-Castaneda, A., Gaultier, A., Gold, R., Kanneganti, T. D. & Nitsch, R. & 2 others, , Jun 1 2015, In: Journal of Clinical Investigation. 125, 6, p. 2547 1 p.Research output: Contribution to journal › Comment/debate
Open Access27 Scopus citations -
Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli
Cronk, J. C., Derecki, N. C., Ji, E., Xu, Y., Lampano, A. E., Smirnov, I., Baker, W., Norris, G. T., Marin, I., Coddington, N., Wolf, Y., Turner, S. D., Aderem, A., Klibanov, A. L., Harris, T. H., Jung, S., Litvak, V. & Kipnis, J., Apr 21 2015, In: Immunity. 42, 4, p. 679-691 13 p.Research output: Contribution to journal › Article › peer-review
Open Access151 Scopus citations -
MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4
Walsh, J. T., Hendrix, S., Boato, F., Smirnov, I., Zheng, J., Lukens, J. R., Gadani, S., Hechler, D., Gölz, G., Rosenberger, K., Kammertöns, T., Vogt, J., Vogelaar, C., Siffrin, V., Radjavi, A., Fernandez-Castaneda, A., Gaultier, A., Gold, R., Kanneganti, T. D. & Nitsch, R. & 2 others, , Feb 2 2015, In: Journal of Clinical Investigation. 125, 2, p. 699-714 16 p.Research output: Contribution to journal › Article › peer-review
Open Access148 Scopus citations -
Structural and functional features of central nervous system lymphatic vessels
Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., Harris, T. H. & Kipnis, J., Jul 16 2015, In: Nature. 523, 7560, p. 337-341 5 p.Research output: Contribution to journal › Article › peer-review
Open Access3129 Scopus citations -
The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury
Gadani, S. P., Walsh, J. T., Smirnov, I., Zheng, J. & Kipnis, J., Feb 18 2015, In: Neuron. 85, 4, p. 703-709 7 p.Research output: Contribution to journal › Article › peer-review
Open Access267 Scopus citations -
2014
Brain antigen-reactive CD4+ T cells are sufficient to support learning behavior in mice with limited T cell repertoire
Radjavi, A., Smirnov, I. & Kipnis, J., Jan 2014, In: Brain, Behavior, and Immunity. 35, p. 58-63 6 p.Research output: Contribution to journal › Article › peer-review
Open Access103 Scopus citations -
Dynamics of the meningeal CD4 + T-cell repertoire are defined by the cervical lymph nodes and facilitate cognitive task performance in mice
Radjavi, A., Smirnov, I., Derecki, N. & Kipnis, J., May 2014, In: Molecular Psychiatry. 19, 5, p. 531-533 3 p.Research output: Contribution to journal › Letter › peer-review
Open Access80 Scopus citations -
Regulatory T cells in central nervous system injury: A double-edged sword
Walsh, J. T., Zheng, J., Smirnov, I., Lorenz, U., Tung, K. & Kipnis, J., Nov 15 2014, In: Journal of Immunology. 193, 10, p. 5013-5022 10 p.Research output: Contribution to journal › Article › peer-review
Open Access66 Scopus citations -
2013
Chronic mild stress eliminates the neuroprotective effect of Copaxone after CNS injury
Smirnov, I., Walsh, J. T. & Kipnis, J., Jul 2013, In: Brain, Behavior, and Immunity. 31, p. 177-182 6 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
2012
Cauda equina repair in the rat: Part 2. Time course of ventral root conduction failure
Mackenzie, S. J., Smirnov, I. & Calancie, B., May 20 2012, In: Journal of neurotrauma. 29, 8, p. 1683-1690 8 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
2011
Cell survival or cell death: Differential vulnerability of long descending and thoracic propriospinal neurons to low thoracic axotomy in the adult rat
Conta Steencken, A. C., Smirnov, I. & Stelzner, D. J., Oct 27 2011, In: Neuroscience. 194, p. 359-371 13 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
2009
Cauda equina repair in the rat: Part 1. Stimulus-evoked EMG for identifying spinal nerves innervating intrinsic tail muscles
Blaskiewicz, D. J., Smirnov, I., Cisu, T., DeRuisseau, L. R., Stelzner, D. J. & Calancie, B., Aug 1 2009, In: Journal of neurotrauma. 26, 8, p. 1405-1416 12 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
2007
A novel immune-based therapy for stroke induces neuroprotection and supports neurogenesis
Ziv, Y., Finkelstein, A., Geffen, Y., Kipnis, J., Smirnov, I., Shpilman, S., Vertkin, I., Kimron, M., Lange, A., Hecht, T., Reyman, K. G., Marder, J. B., Schwartz, M. & Yoles, E., Feb 2007, In: Stroke. 38, 2 PART 2, p. 774-782 9 p.Research output: Contribution to journal › Article › peer-review
Open Access61 Scopus citations -
2006
Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis
Butovsky, O., Landa, G., Kunis, G., Ziv, Y., Avidan, H., Greenberg, N., Schwartz, A., Smirnov, I., Pollack, A., Jung, S. & Schwartz, M., Apr 1 2006, In: Journal of Clinical Investigation. 116, 4, p. 905-915 11 p.Research output: Contribution to journal › Article › peer-review
Open Access225 Scopus citations -
2003
Features of skin-coincubated macrophages that promote recovery from spinal cord injury
Bomstein, Y., Marder, J. B., Vitner, K., Smirnov, I., Lisaey, G., Butovsky, O., Fulga, V. & Yoles, E., Sep 2003, In: Journal of Neuroimmunology. 142, 1-2, p. 10-16 7 p.Research output: Contribution to journal › Article › peer-review
131 Scopus citations -
Vaccination with dendritic cells pulsed with peptides of myelin basic protein promotes functional recovery from spinal cord injury
Hauben, E., Gothilf, A., Cohen, A., Butovsky, O., Nevo, U., Smirnov, I., Yoles, E., Akselrod, S. & Schwartz, M., Sep 24 2003, In: Journal of Neuroscience. 23, 25, p. 8808-8819 12 p.Research output: Contribution to journal › Article › peer-review
Open Access83 Scopus citations -
2001
Posttraumatic therapeutic vaccination with modified myelin self-antigen prevents complete paralysis while avoiding autoimmune disease
Hauben, E., Agranov, E., Gothilf, A., Nero, U., Cohen, A., Smirnov, I., Steinman, L. & Schwartz, M., 2001, In: Journal of Clinical Investigation. 108, 4, p. 591-599 9 p.Research output: Contribution to journal › Article › peer-review
Open Access185 Scopus citations