• 1675
    Citations
20062023

Research activity per year

Personal profile

Research interests

The overarching goal of our research program is to determine how epithelial cell-derived proteins can be harnessed to mitigate the risk of acute lung injury in various settings, to ultimately reduce the burden of end-stage lung disease. A major focus of our work involves distinguishing the role of locally-derived complement proteins in the lung from those present in the blood, and how they modulate the development of pneumonia and acute lung injury. We use multiple in vitro and in vivo approaches to dissect the mechanism by which these proteins contribute to cellular survival. Additionally, we draw upon a robust biorepository of lung tissue, bronchoalveolar lavage fluid and DNA from human subjects to guide and validate our research.

We have active projects investigating lung injury due to pneumonia, and the short- and long-term consequences of ischemia-reperfusion injury occurring in the context of lung transplantation, with the ultimate goal of mitigating the morbidity and mortality occurring due to these forms of lung injury.

Clinical interests

Lung transplantation, end-stage lung disease, critical care medicine

Mentoring

Mentorship is provided on an individualized basis based on the goals of the trainee and the ongoing projects in the research program. Trainees from all backgrounds and all levels of experience are welcome. Please email hkulkarn@wustl.edu for additional information. 

Keywords

  • COVID-19

Available to Mentor:

  • Undergraduate Students
  • Post-Baccalaureate Students
  • PhD/MSTP Students
  • Health Professions Students
  • Postdocs
  • Residents and Fellows

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