Hrishikesh Kulkarni

Assistant Professor of Medicine, Assistant Professor of Molecular Microbiology

    • 394 Citations
    20062020

    Research output per year

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    Personal profile

    Research interests

    The overarching goal of our research program is to determine how epithelial cell-derived proteins can be harnessed to mitigate the risk of acute lung injury in various settings, to ultimately reduce the burden of end-stage lung disease. A major focus of our work involves distinguishing the role of locally-derived complement proteins in the lung from those present in the blood, and how they modulate the development of pneumonia and acute lung injury. We use multiple in vitro and in vivo approaches to dissect the mechanism by which these proteins contribute to cellular survival. Additionally, we draw upon a robust biorepository of lung tissue, bronchoalveolar lavage fluid and DNA from human subjects to guide and validate our research.

    We have active projects investigating lung injury due to pneumonia, and the short- and long-term consequences of ischemia-reperfusion injury occurring in the context of lung transplantation, with the ultimate goal of mitigating the morbidity and mortality occurring due to these forms of lung injury.

    Areas of Clinical Interest

    Acute respiratory distress syndrome, pneumonia, lung transplantation, critical care medicine

    Keywords

    • COVID-19

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    Research Output

    A Functional Polymorphism in C3 is Associated with Worse CLAD-Free Survival

    Kulkarni, H. S., Tague, L. K., Calabrese, D. R., Bajwa, J., Mittler, B., Chen, C., Huang, H. J., Byers, D. E., Hachem, R. R., Kreisel, D., Witt, C. A., Greenland, J. R., Atkinson, J. P. & Gelman, A. E., Apr 1 2020, In : Journal of Heart and Lung Transplantation. 39, 4, p. S56-S57

    Research output: Contribution to journalArticle

  • Impact of SLCO1B3 polymorphisms on clinical outcomes in lung allograft recipients receiving mycophenolic acid

    Tague, L. K., Byers, D. E., Hachem, R., Kreisel, D., Krupnick, A. S., Kulkarni, H. S., Chen, C., Huang, H. J. & Gelman, A., Feb 1 2020, In : Pharmacogenomics Journal. 20, 1, p. 69-79 11 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Increased Alternative Complement Pathway Function and Improved Survival during Critical Illness

    Bain, W., Li, H., van der Geest, R., Moore, S. R., Olonisakin, T. F., Ahn, B., Papke, E., Moghbeli, K., DeSensi, R., Rapport, S., Saul, M., Hulver, M., Xiong, Z., Mallampalli, R. K., Ray, P., Morris, A., Ma, L., Doi, Y., Zhang, Y., Kitsios, G. D. & 5 others, Kulkarni, H. S., McVerry, B. J., Ferreira, V. P., Nouraie, M. & Lee, J. S., Jul 15 2020, In : American journal of respiratory and critical care medicine. 202, 2, p. 230-240 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Local complement activation is associated with primary graft dysfunction after lung transplantation

    Kulkarni, H. S., Ramphal, K., Ma, L., Brown, M., Oyster, M., Speckhart, K. N., Takahashi, T., Byers, D. E., Porteous, M. K., Kalman, L., Hachem, R. R., Rushefski, M., McPhatter, JN., Cano, M., Kreisel, D., Scavuzzo, M., Mittler, B., Cantu, E., Pilely, K., Garred, P. & 4 others, Christie, J. D., Atkinson, J. P., Gelman, A. E. & Diamond, J. M., Sep 3 2020, In : JCI Insight. 5, 17

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations