Personal profile
Research interests
Imagine a future where brain cancer and many other neurological diseases can be diagnosed and treated without the need for invasive surgeries or complex procedures. This future is now within reach, thanks to revolutionary advances in ultrasound technology. Ultrasound can penetrate the intact scalp and skull and focus ultrasound energy to precisely target specific brain areas.
Our mission is to advance the field of NeuroSonics by integrating breakthroughs in neuroscience and ultrasonics to develop noninvasive ultrasound technologies that deepen our understanding of brain function and transform the diagnosis and treatment of neurological diseases.
Clinical interests
Our team is conducting clinical trials to evaluate ultrasound techniques for patients with brain tumors.
Mentoring
My mentoring philosophy is that my trainees' success is my success. My role is to help my mentees cultivate the habits and attitudes necessary for achieving greater success than they would without mentorship. I guide, support, teach, and challenge my mentees to foster their educational and professional growth through mutual respect and trust. I have been honored with the Outstanding Faculty Mentor Award and the Chair's Teaching Award.
Available to Mentor:
- PhD Students
- High School Students
- Undergraduate Students
- Post-Baccalaureate Students
- Health Professions (Medical, OT, PT, Dental, Audiology, etc.) Students
- Postdocs
- Residents and Fellows
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Collaborations and top research areas from the last five years
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Differential effects of focused ultrasound neuromodulation in Parkinson’s disease mice versus healthy mice
Yang, L., Xu, K., Zhang, D., Stark, A., Yue, Y., Kravitz, A., Yang, Y. & Chen, H., Feb 1 2026, In: Journal of Neural Engineering. 23, 1, 016031.Research output: Contribution to journal › Article › peer-review
Open Access -
Ultrasound Applications in the Treatment of Major Depressive Disorder: A Systematic Review of Techniques and Therapeutic Potentials in Clinical Trials and Animal Model Studies
Tan, G., Chen, H. & Leuthardt, E. C., Feb 2026, In: Neuromodulation. 29, 2, p. 187-204 18 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Intranasal versus intravenous AAV delivery: A comparative analysis of brain-targeting efficiency and peripheral exposure in mice
Chukwu, C., Yuan, J. & Chen, H., 2025, (Accepted/In press) In: Gene therapy.Research output: Contribution to journal › Article › peer-review
Open Access -
In vivo two-photon microscopy imaging of focused ultrasound-mediated glymphatic transport in the mouse brain
Gong, Y., Xu, K., Ye, D., Yang, Y., Miller, M. J., Feng, Z., Hu, S. & Chen, H., 2025, (Accepted/In press) In: Journal of Cerebral Blood Flow and Metabolism.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations -
Synthetic torpor: advancing metabolic regulation for medical innovations
Wu, W., Sunagawa, G. A. & Chen, H., Aug 2025, In: Nature Metabolism. 7, 8, p. 1511-1523 13 p.Research output: Contribution to journal › Article › peer-review
1 Link opens in a new tab Scopus citations