Hiroko Yano

Associate Professor of Neurological Surgery, Associate Professor of Genetics, Associate Professor of Neurology

    • Source: Scopus
    1995 …2021

    Research activity per year

    If you made any changes in Pure these will be visible here soon.

    Personal profile

    Research interests

    The age-dependent dysfunction and progressive loss of selective neurons are key characteristics of neurodegenerative diseases including Huntington’s disease (HD). Despite intensive efforts to identify the molecular mechanisms of neuronal death in HD, no curative treatments are currently available. Transcriptional dysregulation in the brain has been suggested to be a common feature of neurodegenerative diseases. In addition, emerging evidence has highlighted the important role of epigenetic mechanisms in the control of transcription. My laboratory focuses on identifying novel epigenetic pathways that cause changes in histone modifications and aberrant gene expression in HD, using cell and animal models of the disease. The underlying hypothesis is that deregulation of epigenetic mechanisms contributes to neuronal death and dysfunction in neurodegenerative diseases. My long-term goal is to develop novel epigenetic-directed therapies to prevent neurodegenerative disease progression.


    Dive into the research topics where Hiroko Yano is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
    • 1 Similar Profiles


    Recent external collaboration on country/territory level. Dive into details by clicking on the dots or