Hiroko Yano

Assistant Professor of Neurological Surgery, Assistant Professor of Genetics, Assistant Professor of Neurology

  • 1883 Citations
19982018

Research output per year

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Personal profile

Research interests

The age-dependent dysfunction and progressive loss of selective neurons are key characteristics of neurodegenerative diseases including Huntington’s disease (HD). Despite intensive efforts to identify the molecular mechanisms of neuronal death in HD, no curative treatments are currently available. Transcriptional dysregulation in the brain has been suggested to be a common feature of neurodegenerative diseases. In addition, emerging evidence has highlighted the important role of epigenetic mechanisms in the control of transcription. My laboratory focuses on identifying novel epigenetic pathways that cause changes in histone modifications and aberrant gene expression in HD, using cell and animal models of the disease. The underlying hypothesis is that deregulation of epigenetic mechanisms contributes to neuronal death and dysfunction in neurodegenerative diseases. My long-term goal is to develop novel epigenetic-directed therapies to prevent neurodegenerative disease progression.

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Research Output

  • 1883 Citations
  • 23 Article
  • 1 Comment/debate
  • 1 Review article

The role of Twist1 in mutant huntingtin–induced transcriptional alterations and neurotoxicity

Pan, Y., Zhu, Y., Yang, W., Tycksen, E., Liu, S., Palucki, J., Zhu, L., Sasaki, Y., Sharma, M. K., Kim, A. H., Zhang, B. & Yano, H., Jul 27 2018, In : Journal of Biological Chemistry. 293, 30, p. 11850-11866 17 p.

Research output: Contribution to journalArticle

  • 1 Scopus citations

    An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma

    Gujar, A. D., Le, S., Mao, D. D., Dadey, D. Y. A., Turski, A., Sasaki, Y., Aum, D., Luo, J., Dahiya, S., Yuan, L., Rich, K., Milbrandt, J., Hallahan, D., Yano, H., Tran, D. D. & Kim, A., Dec 20 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 51, p. E8247-E8256

    Research output: Contribution to journalArticle

    Open Access
  • 36 Scopus citations

    Inhibition of DNA Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity

    Pan, Y., Daito, T., Sasaki, Y., Chung, Y. H., Xing, X., Pondugula, S., Swamidass, S. J., Wang, T., Kim, A. H. & Yano, H., Aug 12 2016, In : Scientific reports. 6, 31022.

    Research output: Contribution to journalArticle

    Open Access
  • 16 Scopus citations

    The CDC20-APC/SOX2 signaling axis: An achilles' heel for glioblastoma

    Gujar, A. D., Yano, H. & Kim, A. H., May 3 2016, In : Molecular and Cellular Oncology. 3, 3, e1075644.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells

    Mao, D. D., Gujar, A. D., Mahlokozera, T., Chen, I., Pan, Y., Luo, J., Brost, T., Thompson, E. A., Turski, A., Leuthardt, E. C., Dunn, G. P., Chicoine, M. R., Rich, K. M., Dowling, J. L., Zipfel, G. J., Dacey, R. G., Achilefu, S., Tran, D. D., Yano, H. & Kim, A. H., Jun 23 2015, In : Cell Reports. 11, 11, p. 1809-1821 13 p.

    Research output: Contribution to journalArticle

    Open Access
  • 44 Scopus citations