• 2657 Citations

Research output per year

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Personal profile

Research interests

Prions are protein infectious particles, initially hypothesized to be the causative agent of certain neurodegenerative disorders in mammals. Prion proteins harbor the ability to exist in structurally distinct states associated with functional alterations that undoubtedly have biological consequences. Although in mammals the prion hypothesis is still subject to debate, it is clear that a similar process occurs in yeast. In yeast, prions serve as heritable epigenetic elements and represent a novel mechanism of phenotypic inheritance. Yeast prions have provided a simple model system to study prion propagation. This model has revolutionized the mammalian prion field, as several yeast proteins have been shown to behave as prions. In addition, the properties of yeast prions are reminiscent of several misfolded proteins that result in neurodegenerative disorders and present a tractable model system to understand the nature of such aggregates. My lab is interested in the biological consequences of yeast prions - in both their capacity to function as a novel epigenetic elements, as well as in their utility to serve as a tractable model for the analysis of protein misfolding and aggregation that mimics important events in several neurodegenerative disorders. We are interested in how prions in yeast impact survival and adaptation. We are also interested in understanding what other prions exist and how broadly prions affect cellular physiology. We are also using prions in yeast to understand how the environment influences protein misfolding and aggregation, a question that has been difficult to address with current model systems of several neurodegenerative disorders.

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Research Output

  • 2657 Citations
  • 42 Article
  • 5 Review article
  • 1 Short survey

Client processing is altered by novel myopathy-causing mutations in the HSP40 J domain

Pullen, M. Y., Weihl, C. C. & True, H. L., Jun 2020, In : PloS one. 15, 6, e0234207.

Research output: Contribution to journalArticle

Open Access
  • Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy

    Bengoechea, R., Findlay, A. R., Bhadra, A. K., Shao, H., Stein, K. C., Pittman, S. K., Daw, J. A. W., Gestwicki, J. E., True, H. L. & Weihl, C. C., Aug 3 2020, In : Journal of Clinical Investigation. 140, 8, p. 4470-4485 16 p.

    Research output: Contribution to journalArticle

    Open Access
  • Lithium chloride corrects weakness and myopathology in a preclinical model of LGMD1D

    Findlay, A. R., Bengoechea, R., Pittman, S. K., Chou, T. F., True, H. L. & Weihl, C. C., Apr 1 2019, In : Neurology: Genetics. 5, 2, e318.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    A toxic imbalance of Hsp70s in Saccharomyces cerevisiae is caused by competition for cofactors

    Keefer, K. M. & True, H. L., Sep 2017, In : Molecular Microbiology. 105, 6, p. 860-868 9 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Corrigendum: Rapid generation of hypomorphic mutations

    Arthur, L. L., Chung, J. J., Janakirama, P., Keefer, K. M., Kolotilin, I., Pavlovic-Djuranovic, S., Chalker, D. L., Grbic, V., Green, R., Menassa, R., True, H. L., Skeath, J. B. & Djuranovic, S., Feb 16 2017, In : Nature communications. 8, 1 p.

    Research output: Contribution to journalArticle

    Open Access
    1 Scopus citations