Personal profile
Research interests
My laboratory builds on insights from human disease genetics to uncover basic molecular mechanisms of gene expression in the nervous system and understand how disruption of these processes can lead to neurological disease. Our current work is focused on understanding how the Rett syndrome protein, MeCP2, functions together with a newly discovered, brain-enriched form of non-CpG DNA methylation to regulate the transcription of extremely long genes in the brain, and how disruption of this regulation contributes to neural dysfunction in Rett syndrome, intellectual disability, and autism spectrum disorder.
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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State-specific enhancer landscapes govern microglial plasticity
Hamagami, N., Kapadia, D., Barclay, K. M., Huang, Y., Abduljawad, N., Cheng, Z., McLaughlin, L., Singhania, D., Ding, X., Yang, J., Sun, Z., Karra, V., Du, S., Bayguinov, P., Yu, G., Li, Y. E., Gabel, H. W. & Li, Q., Feb 10 2026, In: Immunity. 59, 2, p. 288-305.e11Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
From Serendipity to Scalability in Rare Disease Patient Collaborations
Grens, K., Weisenberg, J. L., Ryther, R. C. & Gabel, H. W., Jan 1 2025, In: Missouri Medicine. 122, 1, p. 53-59 7 p.Research output: Contribution to journal › Article › peer-review
1 Link opens in a new tab Scopus citations -
MeCP2 and non-CG DNA methylation stabilize the expression of long genes that distinguish closely related neuron types
Moore, J. R., Nemera, M. T., D’Souza, R. D., Hamagami, N., Clemens, A. W., Beard, D. C., Urman, A., Razia, Y., Rodriguez Mendoza, V., Law, T. E., Edwards, J. R. & Gabel, H. W., Jun 2025, In: Nature neuroscience. 28, 6, p. 1185-1198 14 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations -
Single-cell technology grows up: Leveraging high-resolution omics approaches to understand neurodevelopmental disorders
Dougherty, J. D., Sarafinovska, S., Chaturvedi, S. M., Law, T. E., Akinwe, T. M. & Gabel, H. W., Jun 2025, In: Current Opinion in Neurobiology. 92, 102990.Research output: Contribution to journal › Review article › peer-review
Open Access -
Erratum: A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation (Neuron (2021) 109(23) (3775–3792.e14), (S0896627321006814), (10.1016/j.neuron.2021.09.009))
Chen, J., Lambo, M. E., Ge, X., Dearborn, J. T., Liu, Y., McCullough, K. B., Swift, R. G., Tabachnick, D. R., Tian, L., Noguchi, K., Garbow, J. R., Constantino, J. N., Gabel, H. W., Hengen, K. B., Maloney, S. E. & Dougherty, J. D., Jul 3 2024, In: Neuron. 112, 13, p. 2257 1 p.Research output: Contribution to journal › Comment/debate
Open Access