Research output per year
Research output per year
Personal profile
Research interests
My laboratory builds on insights from human disease genetics to uncover basic molecular mechanisms of gene expression in the nervous system and understand how disruption of these processes can lead to neurological disease. Our current work is focused on understanding how the Rett syndrome protein, MeCP2, functions together with a newly discovered, brain-enriched form of non-CpG DNA methylation to regulate the transcription of extremely long genes in the brain, and how disruption of this regulation contributes to neural dysfunction in Rett syndrome, intellectual disability, and autism spectrum disorder.
Available to Mentor:
- PhD/MSTP Students
Fingerprint
Dive into the research topics where Harrison Gabel is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Erratum: A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation (Neuron (2021) 109(23) (3775–3792.e14), (S0896627321006814), (10.1016/j.neuron.2021.09.009))
Chen, J., Lambo, M. E., Ge, X., Dearborn, J. T., Liu, Y., McCullough, K. B., Swift, R. G., Tabachnick, D. R., Tian, L., Noguchi, K., Garbow, J. R., Constantino, J. N., Gabel, H. W., Hengen, K. B., Maloney, S. E. & Dougherty, J. D., Jul 3 2024, In: Neuron. 112, 13, p. 2257 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
Skeletal abnormalities in mice with Dnmt3a missense mutations
Bell-Hensley, A., Beard, D. C., Feeney, K., Zheng, H., Jiang, Y., Zhang, X., Liu, J., Gabel, H. & McAlinden, A., Jun 2024, In: Bone. 183, 117085.Research output: Contribution to journal › Article › peer-review
Open Access -
Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits
Beard, D. C., Zhang, X., Wu, D. Y., Martin, J. R., Erickson, A., Boua, J. V., Hamagami, N., Swift, R. G., McCullough, K. B., Ge, X., Bell-Hensley, A., Zheng, H., Palmer, C. W., Fuhler, N. A., Lawrence, A. B., Hill, C. A., Papouin, T., Noguchi, K. K., McAlinden, A. & Garbow, J. R. & 3 others, , Nov 28 2023, In: Cell Reports. 42, 11, 113411.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
MeCP2 represses the activity of topoisomerase IIβ in long neuronal genes
Nettles, S. A., Ikeuchi, Y., Lefton, K. B., Abbasi, L., Erickson, A., Agwu, C., Papouin, T., Bonni, A. & Gabel, H. W., Dec 26 2023, In: Cell Reports. 42, 12, 113538.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons
Hamagami, N., Wu, D. Y., Clemens, A. W., Nettles, S. A., Li, A. & Gabel, H. W., May 4 2023, In: Molecular cell. 83, 9, p. 1412-1428.e7Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations