• 3162 Citations

Research output per year

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Personal profile

Research interests

My laboratory builds on insights from human disease genetics to uncover basic molecular mechanisms of gene expression in the nervous system and understand how disruption of these processes can lead to neurological disease. Our current work is focused on understanding how the Rett syndrome protein, MeCP2, functions together with a newly discovered, brain-enriched form of non-CpG DNA methylation to regulate the transcription of extremely long genes in the brain, and how disruption of this regulation contributes to neural dysfunction in Rett syndrome, intellectual disability, and autism spectrum disorder.

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Research Output

  • 3162 Citations
  • 22 Article
  • 2 Short survey
  • 1 Review article

Emerging Insights into the Distinctive Neuronal Methylome

Clemens, A. W. & Gabel, H. W., 2020, (Accepted/In press) In : Trends in Genetics.

Research output: Contribution to journalReview article

  • Functions of Gtf2i and Gtf2ird1 in the developing brain: Transcription, DNA binding and long-term behavioral consequences

    Kopp, N. D., Nygaard, K. R., Liu, Y., McCullough, K. B., Maloney, S. E., Gabel, H. W. & Dougherty, J. D., Jun 3 2020, In : Human molecular genetics. 29, 9, p. 1498-1519 22 p.

    Research output: Contribution to journalArticle

  • MeCP2 Represses Enhancers through Chromosome Topology-Associated DNA Methylation

    Clemens, A. W., Wu, D. Y., Moore, J. R., Christian, D. L., Zhao, G. & Gabel, H. W., Jan 16 2020, In : Molecular cell. 77, 2, p. 279-293.e8

    Research output: Contribution to journalArticle

  • 5 Scopus citations

    The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain

    Goodman, J. V., Yamada, T., Yang, Y., Kong, L., Wu, D. Y., Zhao, G., Gabel, H. W. & Bonni, A., Dec 1 2020, In : Nature communications. 11, 1, 3419.

    Research output: Contribution to journalArticle

    Open Access
  • ME-Class2 reveals context dependent regulatory roles for 5-hydroxymethylcytosine

    Schlosberg, C. E., Wu, D. Y., Gabel, H. W. & Edwards, J. R., Mar 18 2019, In : Nucleic acids research. 47, 5, e28.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations