Haojia Wu

2022

Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies

Wu, H., Villalobos, R. G., Yao, X., Reilly, D., Chen, T., Rankin, M., Myshkin, E., Breyer, M. D. & Humphreys, B. D., Jul 5 2022, In: Cell metabolism. 34, 7, p. 1064-1078.e6

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Spatially Resolved Transcriptomic Analysis of Acute Kidney Injury in a Female Murine Model

Dixon, E. E., Wu, H., Muto, Y., Wilson, P. C. & Humphreys, B. D., Feb 2022, In: Journal of the American Society of Nephrology. 33, 2

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2021

Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive biomarkers of kidney fibrosis

Kidney Precision Medicine Project (KPMP), Sep 2021, In: Kidney International. 100, 3, p. 672-683 12 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney

Muto, Y., Wilson, P. C., Ledru, N., Wu, H., Dimke, H., Waikar, S. S. & Humphreys, B. D., Dec 2021, In: Nature communications. 12, 1, 2190.

Research output: Contribution to journal › Article › peer-review

Open Access

51 Scopus citations

2020

Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury

Kirita, Y., Wu, H., Uchimura, K., Wilson, P. C. & Humphreys, B. D., Jul 7 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 27, p. 15874-15883 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

92 Scopus citations

Harnessing Expressed Single Nucleotide Variation and Single Cell RNA Sequencing to Define Immune Cell Chimerism in the Rejecting Kidney Transplant

Malone, A. F., Wu, H., Fronick, C., Fulton, R., Gaut, J. P. & Humphreys, B. D., Sep 2020, In: Journal of the American Society of Nephrology. 31, 9, p. 1977-1986 10 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Human Pluripotent Stem Cell-Derived Kidney Organoids with Improved Collecting Duct Maturation and Injury Modeling

Uchimura, K., Wu, H., Yoshimura, Y. & Humphreys, B. D., Dec 15 2020, In: Cell Reports. 33, 11, 108514.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Proximal tubule translational profiling during kidney fibrosis reveals proinflammatory and long noncoding RNA expression patterns with sexual dimorphism

Wu, H., Lai, C. F., Chang-Panesso, M. & Humphreys, B. D., Jan 2020, In: Journal of the American Society of Nephrology. 31, 1, p. 23-38 16 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Single cell sequencing and kidney organoids generated from pluripotent stem cells

Wu, H. & Humphreys, B. D., Apr 1 2020, In: Clinical Journal of the American Society of Nephrology. 15, 4, p. 550-556 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Single-nucleus RNA-sequencing profiling of mouse lung reduced dissociation bias and improved rare cell-type detection compared with single-cell RNA sequencing

Koenitzer, J. R., Wu, H., Atkinson, J. J., Brody, S. L. & Humphreys, B. D., Dec 2020, In: American Journal of Respiratory Cell and Molecular Biology. 63, 6, p. 739-747 9 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

2019

A conditionally immortalized Gli1-positive kidney mesenchymal cell line models myofibroblast transition

Ó Hainmhire, E., Wu, H., Muto, Y., Donnelly, E. L., Machado, F. G., Fan, L. X., Chang-Panesso, M. & Humphreys, B. D., Jan 2019, In: American Journal of Physiology - Renal Physiology. 316, 1, p. F63-F75

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Advantages of single-nucleus over single-cell RNA sequencing of adult kidney: Rare cell types and novel cell states revealed in fibrosis

Wu, H., Kirita, Y., Donnelly, E. L. & Humphreys, B. D., Jan 2019, In: Journal of the American Society of Nephrology. 30, 1, p. 23-32 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

189 Scopus citations

FOXM1 drives proximal tubule proliferation during repair from acute ischemic kidney injury

Chang-Panesso, M., Kadyrov, F. F., Lalli, M., Wu, H., Ikeda, S., Kefaloyianni, E., Abdelmageed, M. M., Herrlich, A., Kobayashi, A. & Humphreys, B. D., Dec 2 2019, In: Journal of Clinical Investigation. 129, 12, p. 5501-5517 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

The single-cell transcriptomic landscape of early human diabetic nephropathy

Wilson, P. C., Wu, H., Kirita, Y., Uchimura, K., Ledru, N., Rennke, H. G., Welling, P. A., Waikar, S. S. & Humphreys, B. D., Sep 24 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 39, p. 19619-19625 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

139 Scopus citations

Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies

Morris, A. P., Le, T. H., Wu, H., Akbarov, A., van der Most, P. J., Hemani, G., Smith, G. D., Mahajan, A., Gaulton, K. J., Nadkarni, G. N., Valladares-Salgado, A., Wacher-Rodarte, N., Mychaleckyj, J. C., Dueker, N. D., Guo, X., Hai, Y., Haessler, J., Kamatani, Y., Stilp, A. M., Zhu, G., & 52 othersCook, J. P., Ärnlöv, J., Blanton, S. H., de Borst, M. H., Bottinger, E. P., Buchanan, T. A., Cechova, S., Charchar, F. J., Chu, P. L., Damman, J., Eales, J., Gharavi, A. G., Giedraitis, V., Heath, A. C., Ipp, E., Kiryluk, K., Kramer, H. J., Kubo, M., Larsson, A., Lindgren, C. M., Lu, Y., Madden, P. A. F., Montgomery, G. W., Papanicolaou, G. J., Raffel, L. J., Sacco, R. L., Sanchez, E., Stark, H., Sundstrom, J., Taylor, K. D., Xiang, A. H., Zivkovic, A., Lind, L., Ingelsson, E., Martin, N. G., Whitfield, J. B., Cai, J., Laurie, C. C., Okada, Y., Matsuda, K., Kooperberg, C., Chen, Y. D. I., Rundek, T., Rich, S. S., Loos, R. J. F., Parra, E. J., Cruz, M., Rotter, J. I., Snieder, H., Tomaszewski, M., Humphreys, B. D. & Franceschini, N., Dec 1 2019, In: Nature communications. 10, 1, 29.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

2018

Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics

Wu, H., Uchimura, K., Donnelly, E. L., Kirita, Y., Morris, S. A. & Humphreys, B. D., Dec 6 2018, In: Cell Stem Cell. 23, 6, p. 869-881.e8

Research output: Contribution to journal › Article › peer-review

Open Access

244 Scopus citations

Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy

Yiu, W. H., Li, R. X., Wong, D. W. L., Wu, H. J., Chan, K. W., Chan, L. Y. Y., Leung, J. C. K., Lai, K. N., Sacks, S. H., Zhou, W. & Tang, S. C. W., Aug 1 2018, In: Nephrology Dialysis Transplantation. 33, 8, p. 1323-1332 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

N-acetyl-seryl-aspartyl-lysyl-proline mediates the anti-fibrotic properties of captopril in unilateral ureteric obstructed BALB/C mice

Chan, G. C. W., Wu, H. J., Chan, K. W., Yiu, W. H., Zou, A., Huang, X. R., Lan, H. Y., Lai, K. N. & Tang, S. C. W., Apr 2018, In: Nephrology. 23, 4, p. 297-307 11 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis

Kramann, R., Machado, F., Wu, H., Kusaba, T., Hoeft, K., Schneider, R. K. & Humphreys, B. D., May 3 2018, In: JCI Insight. 3, 9

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Single-cell transcriptomics of a human kidney allograft biopsy specimen defines a diverse inflammatory response

Wu, H., Malone, A. F., Donnelly, E. L., Kirita, Y., Uchimura, K., Ramakrishnan, S. M., Gaut, J. P. & Humphreys, B. D., Aug 2018, In: Journal of the American Society of Nephrology. 29, 8, p. 2069-2080 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

156 Scopus citations

2017

Human induced pluripotent stem cell-derived mesenchymal stem cells prevent adriamycin nephropathy in mice

Wu, H. J., Yiu, W. H., Wong, D. W. L., Li, R. X., Chan, L. Y. Y., Leung, J. C. K., Zhang, Y., Lian, Q., Lai, K. N., Tse, H. F. & Tang, S. C. W., 2017, In: Oncotarget. 8, 61, p. 103640-103656 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2016

Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy

Wong, D. W. L., Yiu, W. H., Wu, H. J., Li, R. X., Liu, Y., Chan, K. W., Leung, J. C. K., Chan, L. Y. Y., Lai, K. N. & Tang, S. C. W., 2016, In: Cell Death and Disease. 7, 3, e2155.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress

Yiu, W. H., Wong, D. W. L., Wu, H. J., Li, R. X., Yam, I., Chan, L. Y. Y., Leung, J. C. K., Lan, H. Y., Lai, K. N. & Tang, S. C. W., Feb 1 2016, In: Kidney International. 89, 2, p. 386-398 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

63 Scopus citations

2015

BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy

Li, R. X., Yiu, W. H., Wu, H. J., Wong, D. W. L., Chan, L. Y. Y., Lin, M., Leung, J. C. K., Lai, K. N. & Tang, S. C. W., 2015, In: Clinical Science. 128, 4, p. 269-280 12 p.

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

N-Acetyl-seryl-aspartyl-lysyl-proline Alleviates Renal Fibrosis Induced by Unilateral Ureteric Obstruction in BALB/C Mice

Chan, G. C. W., Yiu, W. H., Wu, H. J., Wong, D. W. L., Lin, M., Huang, X. R., Lan, H. Y. & Tang, S. C. W., 2015, In: Mediators of Inflammation. 2015, 283123.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2014

Mesenchymal stem cells modulate albumin-induced renal tubular inflammation and fibrosis

Wu, H. J., Yiu, W. H., Li, R. X., Wong, D. W. L., Leung, J. C. K., Chan, L. Y. Y., Zhang, Y., Lian, Q., Lin, M., Tse, H. F., Lai, K. N. & Tang, S. C. W., Mar 19 2014, In: PloS one. 9, 3, e90883.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

2013

The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy

Lin, M., Yiu, W. H., Li, R. X., Wu, H. J., Wong, D. W. L., Chan, L. Y. Y., Leung, J. C. K., Lai, K. N. & Tang, S. C. W., May 2013, In: Kidney International. 83, 5, p. 887-900 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

93 Scopus citations

2012

Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy

Lin, M., Yiu, W. H., Wu, H. J., Chan, L. Y. Y., Leung, J. C. K., Au, W. S., Chan, K. W., Lai, K. N. & Tang, S. C. W., Jan 2012, In: Journal of the American Society of Nephrology. 23, 1, p. 86-102 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

260 Scopus citations

2009

Isolation and culture of primary bovine embryonic stem cell colonies by a novel method

Cao, S., Wang, F., Chen, Z., Liu, Z., Mei, C., Wu, H., Huang, J., Li, C., Zhou, L. & Lin, L., Jun 1 2009, In: Journal of Experimental Zoology Part A: Ecological Genetics and Physiology. 311, 5, p. 368-376 9 p.

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

2008

Efficient production of mice from embryonic stem cells injected into four-or eight-cell embryos by piezo micromanipulation

Huang, J., Deng, K., Wu, H., Liu, Z., Chen, Z., Cao, S., Zhou, L., Ye, X., Keefe, D. L. & Liu, L., Jul 2008, In: STEM CELLS. 26, 7, p. 1883-1890 8 p.

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Haojia Wu

Research output

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