Haojia Wu

Research Output

Research Output per year

2008 2020

• 840 Citations
• 24 Article
• 1 Letter
• 1 Short survey
• 1 Review article

Research Output per year

Research Output per year

Search results

• 2020

  Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury

  Kirita, Y., Wu, H., Uchimura, K., Wilson, P. C. & Humphreys, B. D., Jul 7 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 27, p. 15874-15883 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Kidney Injury
  • Wounds and Injuries
  • Kidney
  • Fibrosis
  • RNA Sequence Analysis
  1 Scopus citations

• Harnessing Expressed Single Nucleotide Variation and Single Cell RNA Sequencing to Define Immune Cell Chimerism in the Rejecting Kidney Transplant

  Malone, A. F., Wu, H., Fronick, C., Fulton, R., Gaut, J. P. & Humphreys, B. D., Sep 2020, In : Journal of the American Society of Nephrology. 31, 9, p. 1977-1986 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Chimerism
  • RNA Sequence Analysis
  • Nucleotides
  • Tissue Donors
  • Transplants

• Proximal tubule translational profiling during kidney fibrosis reveals proinflammatory and long noncoding RNA expression patterns with sexual dimorphism

  Wu, H., Lai, C. F., Chang-Panesso, M. & Humphreys, B. D., Jan 2020, In : Journal of the American Society of Nephrology. 31, 1, p. 23-38 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Long Noncoding RNA
  • Sex Characteristics
  • Fibrosis
  • Kidney
  • Ribosome Subunits
  7 Scopus citations

• Single cell sequencing and kidney organoids generated from pluripotent stem cells

  Wu, H. & Humphreys, B. D., Apr 1 2020, In : Clinical Journal of the American Society of Nephrology. 15, 4, p. 550-556 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Small Cytoplasmic RNA
  • Organoids
  • Pluripotent Stem Cells
  • Kidney
  • Kidney Diseases
  1 Scopus citations
• 2019

  A conditionally immortalized Gli1-positive kidney mesenchymal cell line models myofibroblast transition

  Ó Hainmhire, E., Wu, H., Muto, Y., Donnelly, E. L., Machado, F. G., Fan, L. X., Chang-Panesso, M. & Humphreys, B. D., Jan 2019, In : American Journal of Physiology - Renal Physiology. 316, 1, p. F63-F75

  Research output: Contribution to journal › Article › peer-review

  • Myofibroblasts
  • Cell Line
  • Kidney
  • Mesenchymal Stem Cells
  • RNA Sequence Analysis
  4 Scopus citations

• Advantages of single-nucleus over single-cell RNA sequencing of adult kidney: Rare cell types and novel cell states revealed in fibrosis

  Wu, H., Kirita, Y., Donnelly, E. L. & Humphreys, B. D., Jan 2019, In : Journal of the American Society of Nephrology. 30, 1, p. 23-32 10 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Sequence Analysis
  • Fibrosis
  • Kidney
  • Ureteral Obstruction
  • Datasets
  55 Scopus citations

• FOXM1 drives proximal tubule proliferation during repair from acute ischemic kidney injury

  Chang-Panesso, M., Kadyrov, F. F., Lalli, M., Wu, H., Ikeda, S., Kefaloyianni, E., Abdelmageed, M. M., Herrlich, A., Kobayashi, A. & Humphreys, B. D., Dec 2 2019, In : Journal of Clinical Investigation. 129, 12, p. 5501-5517 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Kidney Injury
  • Wounds and Injuries
  • ErbB Receptors
  • Transcriptome
  • Clone Cells
  15 Scopus citations

• The single-cell transcriptomic landscape of early human diabetic nephropathy

  Wilson, P. C., Wu, H., Kirita, Y., Uchimura, K., Ledru, N., Rennke, H. G., Welling, P. A., Waikar, S. S. & Humphreys, B. D., Sep 24 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 39, p. 19619-19625 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Diabetic Nephropathies
  • Transcriptome
  • Potassium
  • Kidney
  • Mineralocorticoid Receptors
  21 Scopus citations

• Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies

  Morris, A. P., Le, T. H., Wu, H., Akbarov, A., van der Most, P. J., Hemani, G., Smith, G. D., Mahajan, A., Gaulton, K. J., Nadkarni, G. N., Valladares-Salgado, A., Wacher-Rodarte, N., Mychaleckyj, J. C., Dueker, N. D., Guo, X., Hai, Y., Haessler, J., Kamatani, Y., Stilp, A. M., Zhu, G. & 52 others, Cook, J. P., Ärnlöv, J., Blanton, S. H., de Borst, M. H., Bottinger, E. P., Buchanan, T. A., Cechova, S., Charchar, F. J., Chu, P. L., Damman, J., Eales, J., Gharavi, A. G., Giedraitis, V., Heath, A. C., Ipp, E., Kiryluk, K., Kramer, H. J., Kubo, M., Larsson, A., Lindgren, C. M., Lu, Y., Madden, P. A. F., Montgomery, G. W., Papanicolaou, G. J., Raffel, L. J., Sacco, R. L., Sanchez, E., Stark, H., Sundstrom, J., Taylor, K. D., Xiang, A. H., Zivkovic, A., Lind, L., Ingelsson, E., Martin, N. G., Whitfield, J. B., Cai, J., Laurie, C. C., Okada, Y., Matsuda, K., Kooperberg, C., Chen, Y. D. I., Rundek, T., Rich, S. S., Loos, R. J. F., Parra, E. J., Cruz, M., Rotter, J. I., Snieder, H., Tomaszewski, M., Humphreys, B. D. & Franceschini, N., Dec 1 2019, In : Nature communications. 10, 1, 29.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • kidneys
  • genes
  • Kidney Diseases
  • Glomerular Filtration Rate
  • Genes
  17 Scopus citations
• 2018

  Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics

  Wu, H., Uchimura, K., Donnelly, E. L., Kirita, Y., Morris, S. A. & Humphreys, B. D., Dec 6 2018, In : Cell Stem Cell. 23, 6, p. 869-881.e8

  Research output: Contribution to journal › Article › peer-review

  • Organoids
  • Cell Lineage
  • Health Services Needs and Demand
  • Kidney
  • Regulator Genes
  92 Scopus citations

• Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy

  Yiu, W. H., Li, R. X., Wong, D. W. L., Wu, H. J., Chan, K. W., Chan, L. Y. Y., Leung, J. C. K., Lai, K. N., Sacks, S. H., Zhou, W. & Tang, S. C. W., Jan 1 2018, In : Nephrology Dialysis Transplantation. 33, 8, p. 1323-1332 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Complement C5a
  • NOX-D21
  • Diabetic Nephropathies
  • Lipid Metabolism
  • Fibrosis
  15 Scopus citations

• N-acetyl-seryl-aspartyl-lysyl-proline mediates the anti-fibrotic properties of captopril in unilateral ureteric obstructed BALB/C mice

  Chan, G. C. W., Wu, H. J., Chan, K. W., Yiu, W. H., Zou, A., Huang, X. R., Lan, H. Y., Lai, K. N. & Tang, S. C. W., Apr 2018, In : Nephrology. 23, 4, p. 297-307 11 p.

  Research output: Contribution to journal › Article › peer-review

  • goralatide
  • Inbred BALB C Mouse
  • Captopril
  • S 17092-1
  • Angiotensin-Converting Enzyme Inhibitors
  3 Scopus citations

• Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis

  Kramann, R., Machado, F., Wu, H., Kusaba, T., Hoeft, K., Schneider, R. K. & Humphreys, B. D., May 3 2018, In : JCI Insight. 3, 9

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Parabiosis
  • RNA Sequence Analysis
  • Myofibroblasts
  • Monocytes
  • Fibrosis
  14 Scopus citations

• Single-cell transcriptomics of a human kidney allograft biopsy specimen defines a diverse inflammatory response

  Wu, H., Malone, A. F., Donnelly, E. L., Kirita, Y., Uchimura, K., Ramakrishnan, S. M., Gaut, J. P. & Humphreys, B. D., Aug 2018, In : Journal of the American Society of Nephrology. 29, 8, p. 2069-2080 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Allografts
  • Biopsy
  • Kidney
  • RNA Sequence Analysis
  • Endothelial Cells
  65 Scopus citations
• 2017

  Human induced pluripotent stem cell-derived mesenchymal stem cells prevent adriamycin nephropathy in mice

  Wu, H. J., Yiu, W. H., Wong, D. W. L., Li, R. X., Chan, L. Y. Y., Leung, J. C. K., Zhang, Y., Lian, Q., Lai, K. N., Tse, H. F. & Tang, S. C. W., 2017, In : Oncotarget. 8, 61, p. 103640-103656 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Induced Pluripotent Stem Cells
  • Doxorubicin
  • Mesenchymal Stem Cells
  • Survivin
  • Collagen
  7 Scopus citations
• 2016

  Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy

  Wong, D. W. L., Yiu, W. H., Wu, H. J., Li, R. X., Liu, Y., Chan, K. W., Leung, J. C. K., Chan, L. Y. Y., Lai, K. N. & Tang, S. C. W., Jan 1 2016, In : Cell Death and Disease. 7, 3, e2155.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Catenins
  • Cell Death
  • Down-Regulation
  • Kidney
  • Albumins
  7 Scopus citations

• Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress

  Yiu, W. H., Wong, D. W. L., Wu, H. J., Li, R. X., Yam, I., Chan, L. Y. Y., Leung, J. C. K., Lan, H. Y., Lai, K. N. & Tang, S. C. W., Feb 1 2016, In : Kidney International. 89, 2, p. 386-398 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • kallistatin
  • Diabetic Nephropathies
  • Oxidative Stress
  • Kidney
  • Reactive Oxygen Species
  43 Scopus citations
• 2015

  BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy

  Li, R. X., Yiu, W. H., Wu, H. J., Wong, D. W. L., Chan, L. Y. Y., Lin, M., Leung, J. C. K., Lai, K. N. & Tang, S. C. W., 2015, In : Clinical Science. 128, 4, p. 269-280 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Bone Morphogenetic Protein 7
  • Oxidative Stress
  • Advanced Glycation End Products
  • Inflammation
  • Chemokine CCL2
  21 Scopus citations

• N-Acetyl-seryl-aspartyl-lysyl-proline Alleviates Renal Fibrosis Induced by Unilateral Ureteric Obstruction in BALB/C Mice

  Chan, G. C. W., Yiu, W. H., Wu, H. J., Wong, D. W. L., Lin, M., Huang, X. R., Lan, H. Y. & Tang, S. C. W., 2015, In : Mediators of Inflammation. 2015, 283123.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • goralatide
  • Inbred BALB C Mouse
  • Fibrosis
  • Kidney
  • Captopril
  6 Scopus citations
• 2014

  Mesenchymal stem cells modulate albumin-induced renal tubular inflammation and fibrosis

  Wu, H. J., Yiu, W. H., Li, R. X., Wong, D. W. L., Leung, J. C. K., Chan, L. Y. Y., Zhang, Y., Lian, Q., Lin, M., Tse, H. F., Lai, K. N. & Tang, S. C. W., Mar 19 2014, In : PloS one. 9, 3, e90883.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Stem cells
  • mesenchymal stromal cells
  • bone marrow
  • Bone
  • inflammation
  39 Scopus citations
• 2013

  The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy

  Lin, M., Yiu, W. H., Li, R. X., Wu, H. J., Wong, D. W. L., Chan, L. Y. Y., Leung, J. C. K., Lai, K. N. & Tang, S. C. W., May 2013, In : Kidney International. 83, 5, p. 887-900 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • CRX-526
  • Diabetic Nephropathies
  • Osteopontin
  • Nitric Oxide Synthase Type III
  • Knockout Mice
  77 Scopus citations
• 2012

  Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy

  Lin, M., Yiu, W. H., Wu, H. J., Chan, L. Y. Y., Leung, J. C. K., Au, W. S., Chan, K. W., Lai, K. N. & Tang, S. C. W., Jan 2012, In : Journal of the American Society of Nephrology. 23, 1, p. 86-102 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Toll-Like Receptor 4
  • Diabetic Nephropathies
  • Inflammation
  • Kidney
  • Ligands
  212 Scopus citations
• 2009

  Isolation and culture of primary bovine embryonic stem cell colonies by a novel method

  Cao, S., Wang, F., Chen, Z., Liu, Z., Mei, C., Wu, H., Huang, J., Li, C., Zhou, L. & Lin, L., Jun 1 2009, In : Journal of Experimental Zoology Part A: Ecological Genetics and Physiology. 311, 5, p. 368-376 9 p.

  Research output: Contribution to journal › Article › peer-review

  • embryonic stem cells
  • bovine
  • Embryonic Stem Cells
  • Cattle
  • cell
  38 Scopus citations
• 2008

  Efficient production of mice from embryonic stem cells injected into four-or eight-cell embryos by piezo micromanipulation

  Huang, J., Deng, K., Wu, H., Liu, Z., Chen, Z., Cao, S., Zhou, L., Ye, X., Keefe, D. L. & Liu, L., Jul 1 2008, In : STEM CELLS. 26, 7, p. 1883-1890 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Micromanipulation
  • Mouse Embryonic Stem Cells
  • Embryonic Stem Cells
  • Embryonic Structures
  • Tetraploidy
  38 Scopus citations