Gwendalyn Randolph

2022

Cell specific peripheral immune responses predict survival in critical COVID-19 patients

Amrute, J. M., Perry, A. M., Anand, G., Cruchaga, C., Hock, K. G., Farnsworth, C. W., Randolph, G. J., Lavine, K. J. & Steed, A. L., Dec 2022, In: Nature communications. 13, 1, 882.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Lipid absorption and overall intestinal lymphatic transport are impaired following partial small bowel resection in mice

Onufer, E. J., Czepielewski, R. S., Han, Y. H., Courtney, C. M., Sutton, S., Sescleifer, A., Randolph, G. J. & Warner, B. W., Dec 2022, In: Scientific reports. 12, 1, 11527.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Lubiprostone significantly represses fatty liver diseases via induction of mucin and HDL release in mice

Kim, M. Y., Lee, S. J., Randolph, G. & Han, Y. H., Dec 15 2022, In: Life Sciences. 311, 121176.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Na⁺ is shifted from the extracellular to the intracellular compartment and is not inactivated by glycosaminoglycans during high salt conditions in rats

Thowsen, I. M., Karlsen, T. V., Nikpey, E., Haslene-Hox, H., Skogstrand, T., Randolph, G. J., Zinselmeyer, B. H., Tenstad, O. & Wiig, H., May 15 2022, In: Journal of Physiology. 600, 10, p. 2293-2309 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

Dominantly Inherited Alzheimer Network, Nov 17 2022, In: Nature. 611, 7936, p. 585-593 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

100 Scopus citations

Peripheral monocyte–derived cells counter amyloid plaque pathogenesis in a mouse model of Alzheimer’s disease

Yan, P., Kim, K. W., Xiao, Q., Ma, X., Czerniewski, L. R., Liu, H., Rawnsley, D. R., Yan, Y., Randolph, G. J., Epelman, S., Lee, J. M. & Diwan, A., Jun 1 2022, In: Journal of Clinical Investigation. 132, 11, e152565.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity

Uzzan, M., Martin, J. C., Mesin, L., Livanos, A. E., Castro-Dopico, T., Huang, R., Petralia, F., Magri, G., Kumar, S., Zhao, Q., Rosenstein, A. K., Tokuyama, M., Sharma, K., Ungaro, R., Kosoy, R., Jha, D., Fischer, J., Singh, H., Keir, M. E. & Ramamoorthi, N. & 36 others, Gorman, W. E. O., Cohen, B. L., Rahman, A., Cossarini, F., Seki, A., Leyre, L., Vaquero, S. T., Gurunathan, S., Grasset, E. K., Losic, B., Dubinsky, M., Greenstein, A. J., Gottlieb, Z., Legnani, P., George, J., Irizar, H., Stojmirovic, A., Brodmerkel, C., Kasarkis, A., Sands, B. E., Furtado, G., Lira, S. A., Tuong, Z. K., Ko, H. M., Cerutti, A., Elson, C. O., Clatworthy, M. R., Merad, M., Suárez-Fariñas, M., Argmann, C., Hackney, J. A., Victora, G. D., Randolph, G. J., Kenigsberg, E., Colombel, J. F. & Mehandru, S., Apr 2022, In: Nature medicine. 28, 4, p. 766-779 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

76 Scopus citations

2023

An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells

Ceglia, S., Berthelette, A., Howley, K., Li, Y., Mortzfeld, B., Bhattarai, S. K., Yiew, N. K. H., Xu, Y., Brink, R., Cyster, J. G., Hooper, L. V., Randolph, G. J., Bucci, V. & Reboldi, A., Mar 2023, In: Nature immunology. 24, 3, p. 531-544 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Defects in vein valve PROX1/FOXC2 antithrombotic pathway in endothelial cells drive the hypercoagulable state induced by trauma and critical illness

Hoofnagle, M. H., Hess, A., Nalugo, M., Ghosh, S., Hughes, S. W., Fuchs, A., Welsh, J. D., Kahn, M. L., Bochicchio, G. V., Randolph, G. J., Leonard, J. M. & Turnbull, I. R., Aug 1 2023, In: Journal of Trauma and Acute Care Surgery. 95, 2, p. 197-204 8 p.

Research output: Contribution to journal › Article › peer-review

ERG K⁺ channels mediate a major component of action potential repolarization in lymphatic muscle

Kim, H. J., Li, M., Erlich, E. C., Randolph, G. J. & Davis, M. J., Dec 2023, In: Scientific reports. 13, 1, 14890.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Fibrosis induced by resident macrophages has divergent roles in pancreas inflammatory injury and PDAC

Baer, J. M., Zuo, C., Kang, L. I., de la Lastra, A. A., Borcherding, N. C., Knolhoff, B. L., Bogner, S. J., Zhu, Y., Yang, L., Laurent, J., Lewis, M. A., Zhang, N., Kim, K. W., Fields, R. C., Yokoyama, W. M., Mills, J. C., Ding, L., Randolph, G. J. & DeNardo, D. G., Sep 2023, In: Nature immunology. 24, 9, p. 1443-1457 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes

ImmGen Consortium, Gainullina, A., Mogilenko, D. A., Huang, L. H., Todorov, H., Narang, V., Kim, K. W., Yng, L. S., Kent, A., Jia, B., Seddu, K., Krchma, K., Wu, J., Crozat, K., Tomasello, E., Dress, R., See, P., Scott, C., Gibbings, S. & Bajpai, G. & 26 others, Desai, J. V., Maier, B., This, S., Wang, P., Aguilar, S. V., Poupel, L., Dussaud, S., Zhou, T. A., Angeli, V., Blander, J. M., Choi, K., Dalod, M., Dzhagalov, I., Gautier, E. L., Jakubzick, C., Lavine, K., Lionakis, M. S., Paidassi, H., Sieweke, M. H., Ginhoux, F., Guilliams, M., Benoist, C., Merad, M., Randolph, G. J., Sergushichev, A. & Artyomov, M. N., Feb 28 2023, In: Cell Reports. 42, 2, 112046.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Peripheral blood mononuclear cell tissue factor (F3 gene) transcript levels and circulating extracellular vesicles are elevated in severe coronavirus 2019 (COVID-19) disease

Girard, T. J., Antunes, L., Zhang, N., Amrute, J. M., Subramanian, R., Eldem, I., Remy, K., Mazer, M., Erlich, E. C., Cruchaga, C., Steed, A. L., Randolph, G. J. & Di Paola, J., Mar 2023, In: Journal of Thrombosis and Haemostasis. 21, 3, p. 629-638 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Staphylococcus aureus α-toxin impairs early neutrophil localization via electrogenic disruption of store-operated calcium entry

Yang, F., Suo, M., Weli, H., Wong, M., Junidi, A., Cummings, C., Johnson, R., Mallory, K., Liu, A. Y., Greenberg, Z. J., Schuettpelz, L. G., Miller, M. J., Luke, C. J., Randolph, G. J., Zinselmeyer, B. H., Wardenburg, J. B. & Clemens, R. A., Nov 28 2023, In: Cell Reports. 42, 11, 113394.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity

Finlay, C. M., Parkinson, J. E., Zhang, L., Chan, B. H. K., Ajendra, J., Chenery, A., Morrison, A., Kaymak, I., Houlder, E. L., Murtuza Baker, S., Dickie, B. R., Boon, L., Konkel, J. E., Hepworth, M. R., MacDonald, A. S., Randolph, G. J., Rückerl, D. & Allen, J. E., May 9 2023, In: Immunity. 56, 5, p. 1064-1081.e10

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

2024

Apolipoprotein E secreted by astrocytes forms antiparallel dimers in discoidal lipoproteins

Strickland, M. R., Rau, M. J., Summers, B., Basore, K., Wulf, J., Jiang, H., Chen, Y., Ulrich, J. D., Randolph, G. J., Zhang, R., Fitzpatrick, J. A. J., Cashikar, A. G. & Holtzman, D. M., Apr 3 2024, In: Neuron. 112, 7, p. 1100-1109.e5

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis

Canales-Herrerias, P., Uzzan, M., Seki, A., Czepielewski, R. S., Verstockt, B., Livanos, A. E., Raso, F., Dunn, A., Dai, D., Wang, A., Al-Taie, Z., Martin, J., Laurent, T., Ko, H. M., Tokuyama, M., Tankelevich, M., Meringer, H., Cossarini, F., Jha, D. & Krek, A. & 25 others, Paulsen, J. D., Taylor, M. D., Nakadar, M. Z., Wong, J., Erlich, E. C., Mintz, R. L., Onufer, E. J., Helmink, B. A., Sharma, K., Rosenstein, A., Ganjian, D., Chung, G., Dawson, T., Juarez, J., Yajnik, V., Cerutti, A., Faith, J. J., Suarez-Farinas, M., Argmann, C., Petralia, F., Randolph, G. J., Polydorides, A. D., Reboldi, A., Colombel, J. F. & Mehandru, S., Apr 2024, In: Science immunology. 9, 94, eadg7549.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species

Han, J., Gallerand, A., Erlich, E. C., Helmink, B. A., Mair, I., Li, X., Eckhouse, S. R., Dimou, F. M., Shakhsheer, B. A., Phelps, H. M., Chan, M. M., Mintz, R. L., Lee, D. D., Schilling, J. D., Finlay, C. M., Allen, J. E., Jakubzick, C. V., Else, K. J., Onufer, E. J. & Zhang, N. & 1 others, Randolph, G. J., Jan 2024, In: Nature immunology. 25, 1, p. 155-165 11 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Gwendalyn Randolph

Research output

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