• 2415 Citations
19952020

Research output per year

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Personal profile

Research interests

My lab is interested in how ligand-gated ion channel work. We focus on the GABAA and nicotinic acetylcholine receptors. These receptors are mostly located in the postsynaptic cell membrane where they respond to presynaptically released transmitter molecules with a conformational change which results in the flow of ions through the cell membrane. We have been studying the mechanisms by which agonists and antagonists interact with the ligand-gated ion channels, and how these events lead to conformational changes. We are also interested in drug interactions, i.e., how the receptors behave in the presence of clinically used anesthetics and anxiolytics. Most of the work is carried out on recombinant receptors transiently or stably expressed in a heterologous expression system, such as human embryonic kidney cells or Xenopus oocytes. We utilize an array of electrophysiological approaches: cell-attached and excised single-channel patch clamp, whole-cell and outside-out macroscopic recordings, and two-electrode voltage clamp.

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Research Output

  • 2415 Citations
  • 79 Article
  • 9 Review article
  • 2 Editorial
  • 1 Chapter

Analysis of Modulation of the ρ1 GABAA Receptor by Combinations of Inhibitory and Potentiating Neurosteroids Reveals Shared and Distinct Binding Sites

Germann, A. L., Reichert, D. E., Burbridge, A. B., Pierce, S. R., Evers, A. S., Steinbach, J. H. & Akk, G., Oct 1 2020, In : Molecular pharmacology. 98, 4, p. 280-291 12 p.

Research output: Contribution to journalArticle

Open Access
  • Analysis of GABAA receptor activation by combinations of agonists acting at the same or distinct binding sites

    Shin, D. J., Germann, A. L., Covey, D. F., Steinbach, J. H. & Akk, G., Jan 2019, In : Molecular pharmacology. 95, 1, p. 70-81 12 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Application of the co-agonist concerted transition model to analysis of GABAA receptor properties

    Germann, A. L., Steinbach, J. H. & Akk, G., Jan 1 2019, In : Current Neuropharmacology. 17, 9, p. 843-851 9 p.

    Research output: Contribution to journalReview article

  • Applying the Monod-Wyman-Changeux allosteric activation model to pseudo–steady-state responses from GABAA receptors

    Steinbach, J. H. & Akk, G., Jan 2019, In : Molecular pharmacology. 95, 1, p. 106-119 14 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Mild chronic perturbation of inhibition severely alters hippocampal function

    Sun, M. Y., Ziolkowski, L., Lambert, P., Shu, H. J., Keiser, M., Rensing, N., Warikoo, N., Martinek, M., Platnick, C., Benz, A., Bracamontes, J., Akk, G., Steinbach, J. H., Zorumski, C. F., Wong, M. & Mennerick, S., Dec 1 2019, In : Scientific reports. 9, 1, 16431.

    Research output: Contribution to journalArticle

    Open Access