Guoqiao Wang

2023

Longitudinal head-to-head comparison of ¹¹C-PiB and ¹⁸F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-β monoclonal antibodies in dominantly inherited Alzheimer’s disease

for the DIAN-TU Study Team, Chen, C. D., McCullough, A., Gordon, B., Joseph-Mathurin, N., Flores, S., McKay, N. S., Hobbs, D. A., Hornbeck, R., Fagan, A. M., Cruchaga, C., Perrin, R. J., Wang, G., Li, Y., Shi, X., Xiong, C., Snider, B. J., Clifford, D. B., Mills, S., Supnet-Bell, C., & 3 othersMcDade, E., Bateman, R. J. & Benzinger, T. L. S., Jul 2023, In: European Journal of Nuclear Medicine and Molecular Imaging. 50, 9, p. 2669-2682 14 p.

Research output: Contribution to journal › Article › peer-review

2022

Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan

Dominantly Inherited Alzheimer Network (DIAN) & Dominantly Inherited Alzheimer Network (DIAN), Dec 1 2022, In: Brain. 145, 12, p. 4459-4473 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Amyloid-Related Imaging Abnormalities in the DIAN-TU-001 Trial of Gantenerumab and Solanezumab: Lessons from a Trial in Dominantly Inherited Alzheimer Disease

For the Dominantly Inherited Alzheimer Network Trials Unit, Nov 2022, In: Annals of neurology. 92, 5, p. 729-744 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Avoid or Embrace? Practice Effects in Alzheimer’s Disease Prevention Trials

the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU), Jun 16 2022, In: Frontiers in Aging Neuroscience. 14, 883131.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Comparing statistical methods in assessing the prognostic effect of biomarker variability on time-to-event clinical outcomes

Gao, F., Luo, J., Liu, J., Wan, F., Wang, G., Gordon, M. & Xiong, C., Dec 2022, In: BMC Medical Research Methodology. 22, 1, 201.

Research output: Contribution to journal › Article › peer-review

Open Access

Evaluation of dose-dependent treatment effects after mid-trial dose escalation in biomarker, clinical, and cognitive outcomes for gantenerumab or solanezumab in dominantly inherited Alzheimer's disease

for the DIAN-TU Study Team, 2022, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 14, 1, e12367.

Research output: Contribution to journal › Article › peer-review

Open Access

Proportional constrained longitudinal data analysis models for clinical trials in sporadic Alzheimer's disease

Wang, G., Liu, L., Li, Y., Aschenbrenner, A. J., Bateman, R. J., Delmar, P., Schneider, L. S., Kennedy, R. E., Cutter, G. R. & Xiong, C., 2022, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 8, 1, e12286.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Statistical estimation and comparison of group-specific bivariate correlation coefficients in family-type clustered studies

the Dominantly Inherited Alzheimer Network (DIAN) Steering Committee, 2022, In: Journal of Applied Statistics. 49, 9, p. 2246-2270 25 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Weakly activated core neuroinflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer’s disease

Li, F., Eteleeb, A. M., Buchser, W., Sohn, C., Wang, G., Xiong, C., Payne, P. R., McDade, E., Karch, C. M., Harari, O. & Cruchaga, C., Sep 27 2022, In: Frontiers in Aging Neuroscience. 14, 935279.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2021

A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease

the Dominantly Inherited Alzheimer Network–Trials Unit, Jul 2021, In: Nature medicine. 27, 7, p. 1187-1196 10 p.

Research output: Contribution to journal › Article › peer-review

145 Scopus citations

Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease

Dominantly Inherited Alzheimer Network, Mar 23 2021, In: Neurology. 96, 12, p. E1632-E1645

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Predicting Symptom Onset in Sporadic Alzheimer Disease With Amyloid PET

Schindler, S., Li, Y., Buckles, V., Gordon, B., Benzinger, T. L. S., Wang, G., Coble, D., Klunk, W. E., Fagan, A. M., Holtzman, D. M., Bateman, R. J., Morris, J. & Xiong, C., Nov 2 2021, In: Neurology. 97, 18, p. E1823-E1834

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Relative efficiency of equal versus unequal cluster sizes in cluster randomized trials with a small number of clusters

Liu, J., Xiong, C., Liu, L., Wang, G., Jingqin, L., Gao, F., Chen, L. & Li, Y., 2021, In: Journal of Biopharmaceutical Statistics. 31, 2, p. 191-206 16 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2020

Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN)

Dominantly Inherited Alzheimer Network, Jan 1 2020, In: Alzheimer's and Dementia. 16, 1, p. 219-228 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Relationships between big-five personality factors and Alzheimer's disease pathology in autosomal dominant Alzheimer's disease

for the Dominantly Inherited Alzheimer Network, 2020, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 12, 1, e12038.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Sample size re-estimation for confirmatory two-stage flexible multi-arm trial with normal outcomes

Li, Y., Wang, G. & Szychowski, J. M., Jan 2 2020, In: Journal of Statistical Computation and Simulation. 90, 1, p. 157-178 22 p.

Research output: Contribution to journal › Article › peer-review

Single-subject grey matter network trajectories over the disease course of autosomal dominant Alzheimer's disease

Vermunt, L., Dicks, E., Wang, G., Dincer, A., Flores, S., Keefe, S. J., Berman, S. B., Cash, D. M., Chhatwal, J. P., Cruchaga, C., Fox, N. C., Ghetti, B., Graff-Radford, N. R., Hassenstab, J., Karch, C. M., Laske, C., Levin, J., Masters, C. L., McDade, E., Mori, H., & 92 othersMorris, J. C., Noble, J. M., Perrin, R. J., Schofield, P. R., Xiong, C., Scheltens, P., Visser, P. J., Bateman, R. J., Benzinger, T. L. S., Tijms, B. M., Gordon, B. A., Allegri, R., Amtashar, F., Berman, S., Bodge, C., Brandon, S., Brooks, W., Buck, J., Buckles, V., Chea, S., Chrem, P., Chui, H., Cinco, J., Jack, C., D'Mello, M., Donahue, T., Douglas, J., Edigo, N., Erekin-Taner, N., Fagan, A., Farlow, M., Farrar, A., Feldman, H., Flynn, G., Fox, N., Franklin, E., Fujii, H., Gant, C., Gardener, S., Ghetti, B., Goate, A., Goldman, J., Gordon, B., Gray, J., Gurney, J., Hassenstab, J., Hirohara, M., Holtzman, D., Hornbeck, R., Dibari, S. H., Ikeuchi, T., Ikonomovic, S., Jerome, G., Jucker, M., Kasuga, K., Kawarabayashi, T., Klunk, W., Koeppe, R., Kuder-Buletta, E., Laske, C., Levin, J., Marcus, D., Martins, R., Mason, N. S., Maue-Dreyfus, D., McDade, E., Montoya, L., Mori, H., Nagamatsu, A., Neimeyer, K., Noble, J., Norton, J., Perrin, R., Raichle, M., Ringman, J., Roh, J. H., Schofield, P., Shimada, H., Shiroto, T., Shoji, M., Sigurdson, W., Sohrabi, H., Sparks, P., Suzuki, K., Swisher, L., Taddei, K., Wang, J., Wang, P., Weiner, M., Wolfsberger, M., Xiong, C. & Xu, X., Dec 1 2020, In: Brain Communications. 2, 2, fcaa102.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Using practice effects for targeted trials or sub-group analysis in Alzheimer’s disease: How practice effects predict change over time

Wang, G., Kennedy, R. E., Goldberg, T. E., Fowler, M. E., Cutter, G. R. & Schneider, L. S., Feb 1 2020, In: PloS one. 15, 2, e0228064.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2019

Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy with Disease Progression in Patients with Alzheimer Disease

Llibre-Guerra, J. J., Li, Y., Schindler, S. E., Gordon, B. A., Fagan, A. M., Morris, J. C., Benzinger, T. L. S., Hassenstab, J., Wang, G., Allegri, R., Berman, S. B., Chhatwal, J., Farlow, M. R., Holtzman, D. M., Jucker, M., Levin, J., Noble, J. M., Salloway, S., Schofield, P., Karch, C., & 4 othersFox, N. C., Xiong, C., Bateman, R. J. & McDade, E., Dec 13 2019, In: JAMA Network Open. 2, 12, 17126.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies

Su, Y., Flores, S., Wang, G., Hornbeck, R. C., Speidel, B., Joseph-Mathurin, N., Vlassenko, A. G., Gordon, B. A., Koeppe, R. A., Klunk, W. E., Jack, C. R., Farlow, M. R., Salloway, S., Snider, B. J., Berman, S. B., Roberson, E. D., Brosch, J., Jimenez-Velazques, I., van Dyck, C. H., Galasko, D., & 25 othersYuan, S. H., Jayadev, S., Honig, L. S., Gauthier, S., Hsiung, G. Y. R., Masellis, M., Brooks, W. S., Fulham, M., Clarnette, R., Masters, C. L., Wallon, D., Hannequin, D., Dubois, B., Pariente, J., Sanchez-Valle, R., Mummery, C., Ringman, J. M., Bottlaender, M., Klein, G., Milosavljevic-Ristic, S., McDade, E., Xiong, C., Morris, J. C., Bateman, R. J. & Benzinger, T. L. S., Dec 2019, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 180-190 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

76 Scopus citations

Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease

Dominantly Inherited Alzheimer Network, May 2019, In: Alzheimer's and Dementia. 15, 5, p. 655-665 11 p.

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer's disease: A PET substudy interim analysis

Klein, G., Delmar, P., Voyle, N., Rehal, S., Hofmann, C., Abi-Saab, D., Andjelkovic, M., Ristic, S., Wang, G., Bateman, R., Kerchner, G. A., Baudler, M., Fontoura, P. & Doody, R., Dec 12 2019, In: Alzheimer's Research and Therapy. 11, 1, 101.

Research output: Contribution to journal › Article › peer-review

Open Access

117 Scopus citations

Incorporating Biomarkers to Improve Statistical Power of Immunotherapeutic Neoadjuvant Clinical Trials in Patients with Triple-Negative Breast Cancer

Gao, F., Wang, G., Luo, J., Liu, J., Chen, L. & Xiong, C., Jul 3 2019, In: Statistics in Biopharmaceutical Research. 11, 3, p. 210-219 10 p.

Research output: Contribution to journal › Article › peer-review

Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

Dominantly Inherited Alzheimer Network, Feb 1 2019, In: Nature medicine. 25, 2, p. 277-283 7 p.

Research output: Contribution to journal › Article › peer-review

480 Scopus citations

Staging biomarkers in preclinical autosomal dominant Alzheimer's disease by estimated years to symptom onset

Dominantly Inherited Alzheimer Network (DIAN), Apr 2019, In: Alzheimer's and Dementia. 15, 4, p. 506-514 9 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Tau PET in autosomal dominant Alzheimer's disease: Relationship with cognition, dementia and other biomarkers

Gordon, B. A., Blazey, T. M., Christensen, J., Dincer, A., Flores, S., Keefe, S., Chen, C., Su, Y., McDade, E. M., Wang, G., Li, Y., Hassenstab, J., Aschenbrenner, A., Hornbeck, R., Jack, C. R., Ances, B. M., Berman, S. B., Brosch, J. R., Galasko, D., Gauthier, S., & 14 othersLah, J. J., Masellis, M., Van Dyck, C. H., Mintun, M. A., Klein, G., Ristic, S., Cairns, N. J., Marcus, D. S., Xiong, C., Holtzman, D. M., Raichle, M. E., Morris, J. C., Bateman, R. J. & Benzinger, T. L. S., Apr 1 2019, In: Brain. 142, 4, p. 1063-1076 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

103 Scopus citations

Two-period linear mixed effects models to analyze clinical trials with run-in data when the primary outcome is continuous: Applications to Alzheimer's disease

Wang, G., Aschenbrenner, A. J., Li, Y., McDade, E., Liu, L., Benzinger, T. L. S., Bateman, R. J., Morris, J. C., Hassenstab, J. J. & Xiong, C., 2019, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 5, p. 450-457 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2018

A novel cognitive disease progression model for clinical trials in autosomal-dominant Alzheimer's disease

For the Dominantly Inherited Alzheimer Network Trials Unit, Sep 20 2018, In: Statistics in medicine. 37, 21, p. 3047-3055 9 p.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Estimating diagnostic accuracy for clustered ordinal diagnostic groups in the three-class case—Application to the early diagnosis of Alzheimer disease

Xiong, C., Luo, J., Chen, L., Gao, F., Liu, J., Wang, G., Bateman, R. & Morris, J. C., Mar 1 2018, In: Statistical Methods in Medical Research. 27, 3, p. 701-714 14 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease

McDade, E., Wang, G., Gordon, B. A., Hassenstab, J., Benzinger, T. L. S., Buckles, V., Fagan, A. M., Holtzman, D. M., Cairns, N. J., Goate, A. M., Marcus, D. S., Morris, J. C., Paumier, K., Xiong, C., Allegri, R., Berman, S. B., Klunk, W., Noble, J., Ringman, J., Ghetti, B., & 12 othersFarlow, M., Sperling, R. A., Chhatwal, J., Salloway, S., Graff-Radford, N. R., Schofield, P. R., Masters, C., Rossor, M. N., Fox, N. C., Levin, J., Jucker, M. & Bateman, R. J., Oct 2 2018, In: Neurology. 91, 14, p. E1295-E1306

Research output: Contribution to journal › Article › peer-review

168 Scopus citations

Simultaneously evaluating the effect of baseline levels and longitudinal changes in disease biomarkers on cognition in dominantly inherited Alzheimer's disease

the Dominantly Inherited Alzheimer Network (DIAN), Jan 1 2018, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 4, p. 669-676 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study

Gordon, B. A., Blazey, T. M., Su, Y., Hari-Raj, A., Dincer, A., Flores, S., Christensen, J., McDade, E., Wang, G., Xiong, C., Cairns, N. J., Hassenstab, J., Marcus, D. S., Fagan, A. M., Jack, C. R., Hornbeck, R. C., Paumier, K. L., Ances, B. M., Berman, S. B., Brickman, A. M., & 20 othersCash, D. M., Chhatwal, J. P., Correia, S., Förster, S., Fox, N. C., Graff-Radford, N. R., la Fougère, C., Levin, J., Masters, C. L., Rossor, M. N., Salloway, S., Saykin, A. J., Schofield, P. R., Thompson, P. M., Weiner, M. M., Holtzman, D. M., Raichle, M. E., Morris, J. C., Bateman, R. J. & Benzinger, T. L. S., Mar 2018, In: The Lancet Neurology. 17, 3, p. 241-250 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

313 Scopus citations

Treatment satisfaction and bothersome bladder, bowel, sexual symptoms in multiple sclerosis

Wang, G., Marrie, R. A., Fox, R. J., Tyry, T., Cofield, S. S., Cutter, G. R. & Salter, A., Feb 2018, In: Multiple Sclerosis and Related Disorders. 20, p. 16-21 6 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

2017

Baseline EDSS proportions in MS clinical trials affect the overall outcome and power: A cautionary note

Wang, G., Cutter, G. R., Cofield, S. S., Lublin, F., Wolinsky, J. S., Gustafson, T., Krieger, S. & Salter, A., Jun 1 2017, In: Multiple Sclerosis. 23, 7, p. 982-987 6 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Challenging Assumptions About African American Participation in Alzheimer Disease Trials

Kennedy, R. E., Cutter, G. R., Wang, G. & Schneider, L. S., Oct 2017, In: American Journal of Geriatric Psychiatry. 25, 10, p. 1150-1159 10 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Continuous electroencephalography (cEEG) monitoring and outcomes of critically Ill patients

Khawaja, A. M., Wang, G., Cutter, G. R. & Szaflarski, J. P., Feb 4 2017, In: Medical Science Monitor. 23, p. 649-658 10 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

The DIAN-TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model

DIAN-TU Pharma Consortium for the Dominantly Inherited Alzheimer Network, Jan 1 2017, In: Alzheimer's and Dementia. 13, 1, p. 8-19 12 p.

Research output: Contribution to journal › Article › peer-review

197 Scopus citations

2016

Examining the joint effect of disability, health behaviors, and comorbidity on mortality in MS

Salter, A., Tyry, T., Wang, G., Fox, R. J., Cutter, G. & Marrie, R. A., Oct 1 2016, In: Neurology: Clinical Practice. 6, 5, p. 397-408 12 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Health insurance affects the use of disease-modifying therapy in multiple sclerosis

Wang, G., Marrie, R. A., Salter, A. R., Fox, R., Cofield, S. S., Tyry, T. & Cutter, G. R., Jul 26 2016, In: Neurology. 87, 4, p. 365-374 10 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Post Hoc Analyses of ApoE Genotype-Defined Subgroups in Clinical Trials

Kennedy, R. E., Cutter, G. R., Wang, G. & Schneider, L. S., Feb 22 2016, In: Journal of Alzheimer's Disease. 50, 4, p. 1205-1215 11 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2015

Differences in Alzheimer disease clinical trial outcomes based on age of the participants

Schneider, L. S., Kennedy, R. E., Wang, G. & Cutter, G. R., Mar 17 2015, In: Neurology. 84, 11, p. 1121-1127 7 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Effect of sample size re-estimation in adaptive clinical trials for Alzheimer's disease and mild cognitive impairment

Wang, G., Kennedy, R. E., Cutter, G. R. & Schneider, L. S., Oct 14 2015, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 1, 1, p. 63-71 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

To treat or not to treat, that really is not the question

Wang, G. & Cutter, G. R., Jun 10 2015, In: Neurology: Clinical Practice. 5, 3, p. 253-258 6 p.

Research output: Contribution to journal › Article › peer-review

Using baseline cognitive severity for enriching Alzheimer's disease clinical trials: How does Mini-Mental State Examination predict rate of change?

Kennedy, R. E., Cutter, G. R., Wang, G. & Schneider, L. S., Oct 14 2015, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 1, 1, p. 46-52 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

2013

National variation of technical factors in computed tomography of the head

Thickman, D., Wang, G., White, J. & Cutter, G., Jan 1 2013, In: Journal of computer assisted tomography. 37, 4, p. 486-492 7 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Guoqiao Wang

Research output

Search results