Gregory Wu

Associate Professor of Neurology, Associate Professor of Pathology and Immunology

    • 1607 Citations
    19962020

    Research output per year

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    Personal profile

    Research interests

    The Wu lab is dedicated to understanding what triggers the development of immune responses in the central nervous system during health and disease. In particular the lab is focused on Multiple Sclerosis (MS), a disease that affects nearly 400,000 Americans. It is unclear how the immune system contributes to the development of inflammatory plaques throughout the brain and spinal cord in patients with MS. Ongoing research has centered on dendritic cells, a special class of immune cells capable of initiating a wide spectrum of lymphocyte responses. Several lines of evidence suggest that dendritic cells are critical during the pathogenesis of central nervous system inflammation. Much of this data has been derived from studying an animal model for MS, experimental autoimmune encephalomyelitis (EAE). Current work is aimed at understanding how dendritic cells are capable of initiating autoimmune reactions targeting the brain and spinal cord in EAE and MS.

    Areas of Clinical Interest

    Multiple sclerosis, neuromyelitis optica, transverse myelitis, optic neuritis, autoimmune demyelination, lymphocyte-endothelial cell adhesions, immune tolerance therapies.

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    Research Output

    cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity

    Ferris, S. T., Durai, V., Wu, R., Theisen, D. J., Ward, J. P., Bern, M. D., Davidson, J. T., Bagadia, P., Liu, T., Briseño, C. G., Li, L., Gillanders, W., Wu, G. F., Yokoyama, W. M., Murphy, T. L., Schreiber, R. D. & Murphy, K. M., Aug 27 2020, In : Nature. 584, 7822, p. 624-629 6 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations
  • 1 Scopus citations

    Mindfulness, Education, and Exercise for age-related cognitive decline: Study protocol, pilot study results, and description of the baseline sample

    On Behalf of the MEDEX Research Group, 2020, (Accepted/In press) In : Clinical Trials.

    Research output: Contribution to journalArticle

  • Open Access
  • 1 Scopus citations

    Neutrophils promote VLA-4–dependent B cell antigen presentation and accumulation within the meninges during neuroinflammation

    Parker Harp, C. R., Archambault, A. S., Cheung, M., Williams, J. W., Czepielewski, R. S., Duncker, P. C., Kilgore, A. J., Miller, A. T., Segal, B. M., Kim, A. H. J., Randolph, G. J. & Wu, G. F., Nov 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 48, p. 24221-24230 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations