The Wu Lab aims to explore the interface between the nervous and immune systems in order to advance the understanding of neuroimmunologic diseases. We apply various immunological methods to both animal models and human studies to define the regulation of adaptive immune responses during inflammation within the central nervous system. In particular, the lab is focused on Multiple Sclerosis (MS), a disease that affects nearly one million Americans. It is unclear how the immune system contributes to the development of inflammatory plaques throughout the brain and spinal cord in patients with MS. Our objective is to define the pathogenic steps involving in MS and related diseases in order to develop therapeutics. Current work is aimed at understanding how various immune cells, including B cells and microglia, drive autoimmune processes in an animal model for multiple sclerosis known as experimental autoimmune encephalomyelitis. Additional studies include characterization of myeloid cells within human cerebrospinal fluid contributing to inflammation and neurodegeneration. Collaborative efforts to develop highly specific immune therapies for pre-clinical translation to humans by selectively targeting autoreactive T and B cells are also underway

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Multiple sclerosis, neuromyelitis optica, transverse myelitis, optic neuritis, autoimmune demyelination, lymphocyte-endothelial cell adhesions, immune tolerance therapies

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A lack of diversity can be harmful for all of us by potentially perpetuating social injustice and limiting the impact of our work. The Wu lab is committed to diversity, inclusion, and unity. We value individual uniqueness and strive to bring together a diverse team to build a strong, collaborative group. We welcome individuals from all backgrounds.
We aim to foster a positive environment so that each individual can pursue scientific training and knowledge with confidence, creativity, and integrity.