Gregory Lanza

Professor of Medicine, Professor of Biomedical Engineering, James R Hornsby Family Professor in Biomedical Sciences

    • 13651 Citations
    1979 …2020

    Research output per year

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    Personal profile

    Research interests

    Dr. Lanza is a Director of CTRAIN, which is installing a clinical MRI as part of a WU-United Imaging in Healthcare collaboration. The program will be IAC accredited and heavily focused on cardio-oncology. The primary research will be to utilize MRI to assess cardiac toxicity imparted from cancer therapeutics, e.g. TKI, anthracyclines, PD-1, and secondary disease manifestations, e.g., amyloid. in myeloma. The program seeks to simplify MR acquisition and reporting techniques and to project patient therapeutic outcomes using Artificial Intelligence. AI will be used to assist in hybridizing myocardial tissue characterization data, reflective of inflammation, fibrosis, and inflitrate, with demographic and blood based clinical pathology indicators. In addition, Dr. Lanza has coinvented numerous nanoparticle platforms for molecular imaging with MRI, ultrasound, CT, optical, and photoacoustics. In addition, he has developed nanoparticle platforms and compatible prodrugs to address a variety of unmet medical needs in cardiovascular disease, cancer, and arthritis.

    Areas of Clinical Interest

    Heart disease, molecular imaging, in vivo molecular imaging, site targeted ultrasound; supervising and interpreting diagnostic tests, such as echocardiograms, stress echocardiograms, treadmill stress test, holter, event and loop monitors

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    Research Output

    Nanotherapy delivery of c-myc inhibitor targets protumor macrophages and preserves antitumor macrophages in breast cancer

    Esser, A. K., Ross, M. H., Fontana, F., Su, X., Gabay, A., Fox, G. C., Xu, Y., Xiang, J., Schmieder, A. H., Yang, X., Cui, G., Scott, M., Achilefu, S., Chauhan, J., Fletcher, S., Lanza, G. M. & Weilbaecher, K., 2020, In : Theranostics. 10, 17, p. 7510-7526 17 p.

    Research output: Contribution to journalArticle

    Open Access
  • Ultrasound Imaging: Something Old or Something New?

    Lanza, G. M., Sep 1 2020, In : Investigative Radiology. 55, 9, p. 573-577 5 p.

    Research output: Contribution to journalArticle

    An unmet clinical need: The history of thrombus imaging

    Lanza, G. M., Cui, G., Schmieder, A. H., Zhang, H., Allen, J. S., Scott, M. J., Williams, T. & Yang, X., Jun 15 2019, In : Journal of Nuclear Cardiology. 26, 3, p. 986-997 12 p.

    Research output: Contribution to journalReview article

  • 3 Scopus citations

    Diagnosis of LVAD thrombus using a high-avidity fibrin-specific 99mTc probe

    Cui, G., Akers, W. J., Scott, M. J., Nassif, M., Allen, J. S., Schmieder, A. H., Paranandi, K. S., Itoh, A., Beyder, D. D., Achilefu, S., Ewald, G. A. & Lanza, G. M., 2018, In : Theranostics. 8, 4, p. 1168-1179 12 p.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Dual-Contrast 19F/1H Magnetic Resonance Imaging to Characterize Myocardial Infarct Healing

    Lanza, G. M., Nov 1 2018, In : Circulation. Cardiovascular imaging. 11, 11, p. e008457

    Research output: Contribution to journalEditorial

    Open Access