Research output per year
Research output per year
Personal profile
Research interests
The epigenetic regulation of hematopoietic stem cell function and the impact of mutations in the epigenetic machinery in hematopoietic disease
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Dive into the research topics where Grant Challen is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Pevonedistat targets malignant cells in myeloproliferative neoplasms in vitro and in vivo via NFκB pathway inhibition
Kong, T., Laranjeira, A. B. A., Collins, T. B., De Togni, E. S., Wong, A. J., Fulbright, M. C., Ruzinova, M., Celik, H., Challen, G. A., Fisher, D. A. C. & Oh, S., Jan 25 2022, In: Blood Advances. 6, 2, p. 611-623 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms
Celik, H., Krug, E., Zhang, C. R., Han, W., Issa, N., Koh, W. K., Bjeije, H., Kukhar, O., Allen, M., Li, T., Fisher, D. A. C., Fowles, J. S., Wong, T. N., Stubbs, M. C., Koblish, H. K., Oh, S. T. & Challen, G. A., Dec 2021, In: Cancer discovery. 11, 12, p. 3126-3141 16 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling
Hormaechea-Agulla, D., Matatall, K. A., Le, D. T., Kain, B., Long, X., Kus, P., Jaksik, R., Challen, G. A., Kimmel, M. & King, K. Y., Aug 5 2021, In: Cell Stem Cell. 28, 8, p. 1428-1442.e6Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
Epigenomic regulation of human T-cell leukemia virus by chromatin-insulator CTCF
Cheng, X., Joseph, A., Castro, V., Chen-Liaw, A., Skidmore, Z., Payton, J. E., Ratner, L., Edwards, J. R., Ueno, T., Fujisawa, J. I., Rauch, D. A., Challen, G. A., Martinez, M. P., Green, P. & Griffith, M., May 2021, In: PLoS pathogens. 17, 5, e1009577.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Lkb1/stk11 is a tumor suppressor in the progression of myeloproliferative neoplasms
Marinaccio, C., Suraneni, P., Celik, H., Volk, A., Wen, Q. J., Ling, T., Bulic, M., Lasho, T., Koche, R. P., Famulare, C. A., Farnoud, N., Stein, B., Schieber, M., Gurbuxani, S., Root, D. E., Younger, S. T., Hoffman, R., Gangat, N., Ntziachristos, P., Chandel, N. S. & 5 others, , 2021, In: Cancer discovery. 11, 6, p. 1398-1410 13 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations