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Personal profile

Research interests

The epigenetic regulation of hematopoietic stem cell function and the impact of mutations in the epigenetic machinery in hematopoietic disease

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Research Output

Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness

Ostrander, E. L., Kramer, A. C., Mallaney, C., Celik, H., Koh, W. K., Fairchild, J., Haussler, E., Zhang, C. R. C. & Challen, G. A., Apr 14 2020, In : Stem Cell Reports. 14, 4, p. 551-560 10 p.

Research output: Contribution to journalArticle

Open Access
  • 4 Scopus citations

    Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma

    Rauch, D. A., Olson, S. L., Harding, J. C., Sundaramoorthi, H., Kim, Y., Zhou, T., MacLeod, A. R., Challen, G. & Ratner, L., Aug 28 2020, In : Retrovirology. 17, 1, p. 27 1 p.

    Research output: Contribution to journalArticle

    Open Access
  • Radiation induces iatrogenic immunosuppression by indirectly affecting hematopoiesis in bone marrow

    Kapoor, V., Collins, A., Griffith, K., Ghosh, S., Wong, N., Wang, X., Challen, G. A., Krambs, J., Link, D., Hallahan, D. E. & Thotala, D., May 12 2020, In : Oncotarget. 11, 19, p. 1681-1690 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients

    Zhang, C. R. C., Nix, D., Gregory, M., Ciorba, M. A., Ostrander, E. L., Newberry, R. D., Spencer, D. H. & Challen, G. A., Dec 2019, In : Experimental Hematology. 80, p. 36-41.e3

    Research output: Contribution to journalArticle

  • 8 Scopus citations

    IRAK4 mediates colitis-induced tumorigenesis and chemoresistance in colorectal cancer

    Li, Q., Chen, Y., Zhang, D., Grossman, J., Li, L., Khurana, N., Jiang, H., Grierson, P. M., Herndon, J., DeNardo, D. G., Challen, G. A., Liu, J., Ruzinova, M. B., Fields, R. C. & Lim, K. H., 2019, In : JCI Insight. 4, 19, e130867.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations