• 1353 Citations
20052020

Research output per year

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Personal profile

Research interests

Historically, reactive astrocytes and neuroinflammation were thought to arise secondary to neuronal cell death in neurodegenerative diseases with little relevance. However, astrocytes and neuroinflammation are beginning to emerge as critical components of neurological disorders that were once thought to selectively afflict neurons. Our goal is to understand the molecular mechanisms that regulate reactive astrocytes and their neurotoxicity in neurodegenerative diseases, including Alzheimer’s disease, by utilizing a combination of biochemistry, molecular biology, cellular models of inflammation and mouse models of neurodegenerative diseases. We are also interested in developing novel therapies targeting these pathways to reduce neuroinflammation for potential therapeutic intervention.

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Research Output

  • 1353 Citations
  • 12 Article
  • 3 Comment/debate
  • 3 Review article
  • 1 Chapter

Unfolding the mystery of UPR in astrocytes

Gallardo, G., Jan 29 2020, In : Science translational medicine. 12, 528, eaba2916.

Research output: Contribution to journalComment/debate

1 Scopus citations

Amyloid-β and Tau at the Crossroads of Alzheimer’s Disease

Gallardo, G. & Holtzman, D. M., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer, p. 187-203 17 p. (Advances in Experimental Medicine and Biology; vol. 1184).

Research output: Chapter in Book/Report/Conference proceedingChapter

  • 5 Scopus citations

    Microglia seeding the brain for α-synuclein pathology

    Gallardo, G., Jun 12 2019, In : Science translational medicine. 11, 496, eaax9563.

    Research output: Contribution to journalReview article

  • 1 Scopus citations

    Mitochondria fragments fuel the fire of neuroinflammation

    Gallardo, G., Oct 2 2019, In : Science translational medicine. 11, 512, eaaz3714.

    Research output: Contribution to journalComment/debate

    Neurogenesis takes a hit in Alzheimer's disease

    Gallardo, G., Jan 1 2019, In : Science translational medicine. 11, 490, eaax1726.

    Research output: Contribution to journalReview article

  • 1 Scopus citations