Ghazal Ashrafi

Assistant Professor of Cell Biology and Physiology, Assistant Professor of Genetics

    • Source: Scopus

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    The brain is the most energy consuming organ of the body and is highly sensitive to energetic perturbations. However, regulatory mechanism that modulate neuronal metabolism are poorly understood. In firing nerve terminals, both glycolysis and oxidative phosphorylation (OxPhos) are rapidly upregulated to meet the energetic requirements of synaptic activity1. While this upregulation represents transient modulation of neuronal metabolism, it is not clear how neurons adapt to chronic changes in energetic burden that also occur in neurodegenerative diseases such as Alzheimer’s disease (AD). The research in my lab will be focused on uncovering novel regulators of glycolytic and mitochondrial metabolism at the synapse and their role in the pathology of Alzheimer’s disease.


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    • Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy

      Harbauer, A. B., Hees, J. T., Wanderoy, S., Segura, I., Gibbs, W., Cheng, Y., Ordonez, M., Cai, Z., Cartoni, R., Ashrafi, G., Wang, C., Perocchi, F., He, Z. & Schwarz, T. L., May 4 2022, In: Neuron. 110, 9, p. 1516-1531.e9

      Research output: Contribution to journalArticlepeer-review

      1 Scopus citations
    • Mitochondria in Neuronal Health: From Energy Metabolism to Parkinson's Disease

      Murali Mahadevan, H., Hashemiaghdam, A., Ashrafi, G. & Harbauer, A. B., Sep 2021, In: Advanced Biology. 5, 9, 2100663.

      Research output: Contribution to journalReview articlepeer-review

      Open Access
      8 Scopus citations
    • Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures Metabolic Flexibility of Neurotransmission

      Ashrafi, G., de Juan-Sanz, J., Farrell, R. J. & Ryan, T. A., Feb 19 2020, In: Neuron. 105, 4, p. 678-687.e5

      Research output: Contribution to journalArticlepeer-review

      42 Scopus citations
    • SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

      Koopmans, F., van Nierop, P., Andres-Alonso, M., Byrnes, A., Cijsouw, T., Coba, M. P., Cornelisse, L. N., Farrell, R. J., Goldschmidt, H. L., Howrigan, D. P., Hussain, N. K., Imig, C., de Jong, A. P. H., Jung, H., Kohansalnodehi, M., Kramarz, B., Lipstein, N., Lovering, R. C., MacGillavry, H., Mariano, V. & 53 others, Mi, H., Ninov, M., Osumi-Sutherland, D., Pielot, R., Smalla, K. H., Tang, H., Tashman, K., Toonen, R. F. G., Verpelli, C., Reig-Viader, R., Watanabe, K., van Weering, J., Achsel, T., Ashrafi, G., Asi, N., Brown, T. C., De Camilli, P., Feuermann, M., Foulger, R. E., Gaudet, P., Joglekar, A., Kanellopoulos, A., Malenka, R., Nicoll, R. A., Pulido, C., de Juan-Sanz, J., Sheng, M., Südhof, T. C., Tilgner, H. U., Bagni, C., Bayés, À., Biederer, T., Brose, N., Chua, J. J. E., Dieterich, D. C., Gundelfinger, E. D., Hoogenraad, C., Huganir, R. L., Jahn, R., Kaeser, P. S., Kim, E., Kreutz, M. R., McPherson, P. S., Neale, B. M., O'Connor, V., Posthuma, D., Ryan, T. A., Sala, C., Feng, G., Hyman, S. E., Thomas, P. D., Smit, A. B. & Verhage, M., Jul 17 2019, In: Neuron. 103, 2, p. 217-234.e4

      Research output: Contribution to journalArticlepeer-review

      Open Access
      125 Scopus citations
    • Glucose metabolism in nerve terminals

      Ashrafi, G. & Ryan, T. A., Aug 2017, In: Current Opinion in Neurobiology. 45, p. 156-161 6 p.

      Research output: Contribution to journalReview articlepeer-review

      64 Scopus citations