Ghazal Ashrafi

Assistant Professor of Cell Biology and Physiology, Assistant Professor of Genetics

    • Source: Scopus

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    The brain is the most energy consuming organ of the body and is highly sensitive to energetic perturbations. However, regulatory mechanism that modulate neuronal metabolism are poorly understood. In firing nerve terminals, both glycolysis and oxidative phosphorylation (OxPhos) are rapidly upregulated to meet the energetic requirements of synaptic activity1. While this upregulation represents transient modulation of neuronal metabolism, it is not clear how neurons adapt to chronic changes in energetic burden that also occur in neurodegenerative diseases such as Alzheimer’s disease (AD). The research in my lab will be focused on uncovering novel regulators of glycolytic and mitochondrial metabolism at the synapse and their role in the pathology of Alzheimer’s disease.


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    • Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures Metabolic Flexibility of Neurotransmission

      Ashrafi, G., de Juan-Sanz, J., Farrell, R. J. & Ryan, T. A., Feb 19 2020, In: Neuron. 105, 4, p. 678-687.e5

      Research output: Contribution to journalArticlepeer-review

      23 Scopus citations
    • SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

      Koopmans, F., van Nierop, P., Andres-Alonso, M., Byrnes, A., Cijsouw, T., Coba, M. P., Cornelisse, L. N., Farrell, R. J., Goldschmidt, H. L., Howrigan, D. P., Hussain, N. K., Imig, C., de Jong, A. P. H., Jung, H., Kohansalnodehi, M., Kramarz, B., Lipstein, N., Lovering, R. C., MacGillavry, H., Mariano, V. & 53 others, Mi, H., Ninov, M., Osumi-Sutherland, D., Pielot, R., Smalla, K. H., Tang, H., Tashman, K., Toonen, R. F. G., Verpelli, C., Reig-Viader, R., Watanabe, K., van Weering, J., Achsel, T., Ashrafi, G., Asi, N., Brown, T. C., De Camilli, P., Feuermann, M., Foulger, R. E., Gaudet, P., Joglekar, A., Kanellopoulos, A., Malenka, R., Nicoll, R. A., Pulido, C., de Juan-Sanz, J., Sheng, M., Südhof, T. C., Tilgner, H. U., Bagni, C., Bayés, À., Biederer, T., Brose, N., Chua, J. J. E., Dieterich, D. C., Gundelfinger, E. D., Hoogenraad, C., Huganir, R. L., Jahn, R., Kaeser, P. S., Kim, E., Kreutz, M. R., McPherson, P. S., Neale, B. M., O'Connor, V., Posthuma, D., Ryan, T. A., Sala, C., Feng, G., Hyman, S. E., Thomas, P. D., Smit, A. B. & Verhage, M., Jul 17 2019, In: Neuron. 103, 2, p. 217-234.e4

      Research output: Contribution to journalArticlepeer-review

      79 Scopus citations
    • Glucose metabolism in nerve terminals

      Ashrafi, G. & Ryan, T. A., Aug 2017, In: Current Opinion in Neurobiology. 45, p. 156-161 6 p.

      Research output: Contribution to journalReview articlepeer-review

      55 Scopus citations
    • GLUT4 Mobilization Supports Energetic Demands of Active Synapses

      Ashrafi, G., Wu, Z., Farrell, R. J. & Ryan, T. A., Feb 8 2017, In: Neuron. 93, 3, p. 606-615.e3

      Research output: Contribution to journalArticlepeer-review

      Open Access
      106 Scopus citations
    • Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons

      Cao, M., Wu, Y., Ashrafi, G., McCartney, A. J., Wheeler, H., Bushong, E. A., Boassa, D., Ellisman, M. H., Ryan, T. A. & De Camilli, P., Feb 22 2017, In: Neuron. 93, 4, p. 882-896.e5

      Research output: Contribution to journalArticlepeer-review

      Open Access
      65 Scopus citations