• 29896 Citations
1985 …2020

Research output per year

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Personal profile

Research interests

The general theme of the Dorn laboratory revolves around how neurohormonal stimulation of the heart contributes to development of cardiac hypertrophy and its progression to heart failure. Our team uses cell and molecular biology platforms to address mechanistic questions relating to receptor-effector coupling, genetically manipulated mice to define functional relevance of signaling pathways in the integrated cardiovascular system, and human genomics that bridge the bench and bedside. Current translational projects investigate how adrenergic receptor desensitization by G-protein receptor kinases affects the stressed or failing heart, and how regulated expression of cardiac microRNAs compensates for myocardial disease. Basic investigations examine novel mechanisms of apoptotic and non-apoptotic programmed cell death by Bcl2-family proteins, and how cardiac injury is mediated by calpain-mediated proteolytic processing of protein kinase C. The laboratory has special expertise in genetic manipulation of mouse hearts using conditional gene ablation and overexpression approaches, and in microsurgical modeling and analytical techniques.

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Research Output

Discovery of 6-Phenylhexanamide Derivatives as Potent Stereoselective Mitofusin Activators for the Treatment of Mitochondrial Diseases

Dang, X., Zhang, L., Franco, A., Li, J., Rocha, A. G., Devanathan, S., Dolle, R. E., Bernstein, P. R. & Dorn, G. W., Jul 9 2020, In : Journal of Medicinal Chemistry. 63, 13, p. 7033-7051 19 p.

Research output: Contribution to journalArticle

  • Mitofusin 2 Dysfunction and Disease in Mice and Men

    Dorn, G. W., Jul 9 2020, In : Frontiers in Physiology. 11, 782.

    Research output: Contribution to journalReview article

    Open Access
  • Mitofusins as mitochondrial anchors and tethers

    Dorn, G. W., May 2020, In : Journal of Molecular and Cellular Cardiology. 142, p. 146-153 8 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations

    Sex and BNIP3 genotype, rather than acute lipid injection, modulate hepatic mitochondrial function and steatosis risk in mice

    Fuller, K. N. Z., McCoin, C. S., Allen, J., Bell-Glenn, S., Koestler, D. C., Dorn, G. W. & Thyfault, J. P., May 2020, In : Journal of Applied Physiology. 128, 5, p. 1251-1261 11 p.

    Research output: Contribution to journalArticle

  • Targeting mitochondrial fusion and fission proteins for cardioprotection

    Hernandez-Resendiz, S., Prunier, F., Girao, H., Dorn, G. & Hausenloy, D. J., Jun 1 2020, In : Journal of Cellular and Molecular Medicine. 24, 12, p. 6571-6585 15 p.

    Research output: Contribution to journalReview article

    Open Access
  • 5 Scopus citations