George Kyei

Assistant Professor of Medicine, Assistant Professor of Molecular Microbiology

    • 1735 Citations
    20042020

    Research output per year

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    Personal profile

    Research interests

    My research interests are in HIV latency and reservoir maintenance. An important obstacle to the cure of HIV is viral replication in long lived, quiescent immune cells such as macrophages, dendritic cells and resting T cells. These cells serve as sources of viral production once medications are discontinued, making life-long therapy a necessity. In addition, slow or inefficient replication makes the virus less susceptible to current antiretrovirals in these cell types. My research efforts are focused on (i) characterization of factors that control HIV replication in macrophages, dendritic and resting T cells and (ii) identification of cellular factors and small molecules required for HIV reactivation in latently infected cells. (iii) Characterization of the HIV reservoir.

    Areas of Clinical Interest

    HIV latency and reservoir maintenance

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    Research Output

    • 1735 Citations
    • 15 Article
    • 2 Short survey
    • 1 Review article

    Characterization of frequency-chirped dynamic nuclear polarization in rotating solids

    Judge, P. T., Sesti, E. L., Alaniva, N., Saliba, E. P., Price, L. E., Gao, C., Halbritter, T., Sigurdsson, S. T., Kyei, G. B. & Barnes, A. B., Apr 2020, In : Journal of Magnetic Resonance. 313, 106702.

    Research output: Contribution to journalArticle

  • Dynamic Nuclear Polarization with Electron Decoupling in Intact Human Cells and Cell Lysates

    Judge, P. T., Sesti, E. L., Price, L. E., Albert, B. J., Alaniva, N., Saliba, E. P., Halbritter, T., Sigurdsson, S. T., Kyei, G. B. & Barnes, A. B., Mar 26 2020, In : Journal of Physical Chemistry B. 124, 12, p. 2323-2330 8 p.

    Research output: Contribution to journalArticle

  • In situ detection of endogenous HIV activation by dynamic nuclear polarization nmr and flow cytometry

    Overall, S. A., Price, L. E., Albert, B. J., Gao, C., Alaniva, N., Judge, P. T., Sesti, E. L., Wender, P. A., Kyei, G. B. & Barnes, A. B., Jul 1 2020, In : International journal of molecular sciences. 21, 13, p. 1-13 13 p., 4649.

    Research output: Contribution to journalArticle

    Open Access
  • Promoting undetectable equals untransmittable in sub-saharan africa: Implication for clinical practice and art adherence

    Thomford, N. E., Mhandire, D., Dandara, C. & Kyei, G. B., Sep 1 2020, In : International journal of environmental research and public health. 17, 17, p. 1-11 11 p., 6163.

    Research output: Contribution to journalArticle

    Open Access
  • The dual-specificity kinase DYRK1A modulates the levels of cyclin L2 to control HIV replication in macrophages

    Kisaka, J. K., Ratner, L. & Kyei, G. B., Mar 1 2020, In : Journal of virology. 94, 6, e01583-19.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations