Research output per year
Research output per year
Personal profile
Research interests
I am interested in the development of new agents and treatment approaches for patients with myelodysplastic syndromes and acute myeloid leukemia. In conjunction with Drs. John DiPersio and Michael Rettig, we are currently conducting a Phase I/II Study of AMD3100 (plerixafor) in combination with mitoxantrone, etoposide and cytarabine for relapsed or refractory AML. AMD3100 is a CXCR4 antagonist currently under clinical development as a stem cell mobilizing agent for use in hematopoietic transplantation. Preclinical evidence suggests that AMD3100 can disrupt the interaction of leukemic blasts with the bone marrow microenvironment sensitizing these cells to genotoxic stresses such as chemotherapy. This trial is designed as a proof of concept study to determine if AMD3100 "priming" can improve response rates in AML.
Clinical interests
Bone marrow transplant, oncology, cancer, lymphoma, leukemia, aplastic anemia
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Collaborations and top research areas from the last five years
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Deficit accumulation frailty index and treatment tolerability in AML: data from CALGB 11001 and 11002 (Alliance)
Lai, C., Lee, M., Bobek, O., Le-Rademacher, J., Mandrekar, S., Roboz, G. J., Uy, G. L., Mandelblatt, J. S. & Klepin, H. D., Jan 28 2025, In: Blood Advances. 9, 2, p. 398-401 4 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Itacitinib for prevention of graft-versus-host disease and cytokine release syndrome in haploidentical transplantation
Abboud, R., Schroeder, M. A., Rettig, M. P., Jayasinghe, R. G., Gao, F., Eisele, J., Gehrs, L., Ritchey, J., Choi, J., Abboud, C. N., Pusic, I., Jacoby, M., Westervelt, P., Christopher, M., Cashen, A., Ghobadi, A., Stockerl-Goldstein, K., Uy, G. L. & DiPersio, J. F., Mar 27 2025, In: Blood. 145, 13, p. 1382-1394 13 p.Research output: Contribution to journal › Article › peer-review
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Monitoring clonal burden as an alternative to blast count for myelodysplastic neoplasm treatment response: EARLY PHASE STUDIES
Jacoby, M. A., Duncavage, E. D., Khanna, A., Chang, G. S., Nonavinkere Srivatsan, S., Miller, C. A., Gao, F., Robinson, J., Shao, J., Fulton, R. S., Fronick, C. C., O’Laughlin, M., Heath, S. E., Brendel, K., Chavez, M., DiPersio, J. F., Abboud, C. N., Stockerl-Goldstein, K., Westervelt, P. & Cashen, A. & 7 others, , Jan 2025, In: Leukemia. 39, 1, p. 166-177 12 p.Research output: Contribution to journal › Article › peer-review
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Prognostic, biological, and structural implications of FLT3-JMD point mutations in acute myeloid leukemia: an analysis of Alliance studies
Anabtawi, N., Nicolet, D., Alotaibi, N., Buelow, D. R., Orwick, S., Gregory, T., Raj, R., Coleman, K., Kolitz, J. E., Powell, B. L., Blum, W. G., Baer, M. R., Byrd, J. C., Stock, W., Uy, G. L., Mrózek, K., Eisfeld, A. K., Cheng, X., Baker, S. D. & Blachly, J. S., Mar 2025, In: Leukemia. 39, 3, p. 623-631 9 p., 612880.Research output: Contribution to journal › Article › peer-review
Open Access -
Results of Cancer and Leukemia Group B 10102 (Alliance), a Phase 1/2 Study
Luskin, M. R., Yin, J., Lozanski, G., Curran, E., Malnassy, G., Mrózek, K., Bloomfield, C. D., Cataland, S. R., Fulton, N., Kolitz, J., Laplant, B., Kour, O., Powell, B. L., Vij, R., Wang, E. S., Grinblatt, D., Stone, R. M., Uy, G. L., Larson, R. A. & Stock, W., Feb 15 2025, In: Cancer. 131, 4, e35750.Research output: Contribution to journal › Article › peer-review
Open Access