Research output per year
Research output per year
Personal profile
Research interests
I am interested in the development of new agents and treatment approaches for patients with myelodysplastic syndromes and acute myeloid leukemia. In conjunction with Drs. John DiPersio and Michael Rettig, we are currently conducting a Phase I/II Study of AMD3100 (plerixafor) in combination with mitoxantrone, etoposide and cytarabine for relapsed or refractory AML. AMD3100 is a CXCR4 antagonist currently under clinical development as a stem cell mobilizing agent for use in hematopoietic transplantation. Preclinical evidence suggests that AMD3100 can disrupt the interaction of leukemic blasts with the bone marrow microenvironment sensitizing these cells to genotoxic stresses such as chemotherapy. This trial is designed as a proof of concept study to determine if AMD3100 "priming" can improve response rates in AML.
Clinical interests
Bone marrow transplant, oncology, cancer, lymphoma, leukemia, aplastic anemia
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A randomized phase II/III study of ‘novel therapeutics’ versus azacitidine in newly diagnosed patients with acute myeloid leukemia (AML), high-risk myelodysplastic syndrome (MDS), or chronic myelomonocytic leukemia (CMML), age 60 or older: a report of the comparison of azacitidine and nivolumab to azacitidine: SWOG S1612
Assouline, S., Michaelis, L. C., Othus, M., Hay, A. E., Walter, R. B., Jacoby, M. A., Schroeder, M. A., Uy, G. L., Law, L. Y., Cheema, F., Sweet, K. L., Asch, A. S., Liu, J., Moseley, A. B., Maher, T., Kingsbury, L. L., Fang, M., Radich, J., Little, R. F. & Erba, H. P., 2023, In: Leukemia and Lymphoma. 64, 2, p. 473-477 5 p.Research output: Contribution to journal › Letter › peer-review
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Outcome prediction by the 2022 European LeukemiaNet genetic-risk classification for adults with acute myeloid leukemia: an Alliance study
Mrózek, K., Kohlschmidt, J., Blachly, J. S., Nicolet, D., Carroll, A. J., Archer, K. J., Mims, A. S., Larkin, K. T., Orwick, S., Oakes, C. C., Kolitz, J. E., Powell, B. L., Blum, W. G., Marcucci, G., Baer, M. R., Uy, G. L., Stock, W., Byrd, J. C. & Eisfeld, A. K., 2023, (Accepted/In press) In: Leukemia.Research output: Contribution to journal › Article › peer-review
Open Access -
A phase I study of the fully human, fragment crystallizable-engineered, anti-CD-33 monoclonal antibody BI 836858 in patients with previously-treated acute myeloid leukemia
Vasu, S., Altman, J. K., Uy, G. L., Tallman, M. S., Gojo, I., Lozanski, G., Burkard, U., Osswald, A., James, P., Rüter, B. & Blum, W., Mar 2022, In: Haematologica. 107, 3, p. 770-773 4 p.Research output: Contribution to journal › Letter › peer-review
Open Access5 Scopus citations -
Clinical and molecular relevance of genetic variants in the non-coding transcriptome of patients with cytogenetically normal acute myeloid leukemia
Papaioannou, D., Ozer, H. G., Nicolet, D., Urs, A. P., Herold, T., Mrózek, K., Batcha, A. M. N., Metzeler, K. H., Yilmaz, A. S., Volinia, S., Bill, M., Kohlschmidt, J., Pietrzak, M., Walker, C. J., Carroll, A. J., Braess, J., Powell, B. L., Eisfeld, A. K., Uy, G. L., Wang, E. S., & 6 others, May 2022, In: Haematologica. 107, 5, p. 1034-1044 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Decitabine salvage for TP53-mutated, relapsed/refractory acute myeloid leukemia after cytotoxic induction therapy
Ferraro, F., Gruszczynska, A., Ruzinova, M. B., Miller, C. A., Percival, M. E., Uy, G. L., Pusic, I., Jacoby, M. A., Christopher, M. J., Kim, M. Y., Westervelt, P., Cashen, A. F., Schroeder, M. A., DiPersio, J. F., Abboud, C. N., Wartman, L. D., Gao, F., Link, D. C., Ley, T. J. & Welch, J. S., Jul 2022, In: Haematologica. 107, 7, p. 1709-1713 5 p.Research output: Contribution to journal › Letter › peer-review
Open Access1 Scopus citations