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Geoffrey Uy

Professor of Medicine, Director of the Bone Marrow Transplantation and Myeloid Malignancies

 https://orcid.org/0000-0002-7809-0996
    • 9459
      Citations
    1997 …2024

    Research activity per year

    Personal profile

    Research interests

    I am interested in the development of new agents and treatment approaches for patients with myelodysplastic syndromes and acute myeloid leukemia. In conjunction with Drs. John DiPersio and Michael Rettig, we are currently conducting a Phase I/II Study of AMD3100 (plerixafor) in combination with mitoxantrone, etoposide and cytarabine for relapsed or refractory AML. AMD3100 is a CXCR4 antagonist currently under clinical development as a stem cell mobilizing agent for use in hematopoietic transplantation. Preclinical evidence suggests that AMD3100 can disrupt the interaction of leukemic blasts with the bone marrow microenvironment sensitizing these cells to genotoxic stresses such as chemotherapy. This trial is designed as a proof of concept study to determine if AMD3100 "priming" can improve response rates in AML.

    Clinical interests

    Bone marrow transplant, oncology, cancer, lymphoma, leukemia, aplastic anemia

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    • Blinatumomab for MRD-Negative Acute Lymphoblastic Leukemia in Adults

      Litzow, M. R., Sun, Z., Mattison, R. J., Paietta, E. M., Roberts, K. G., Zhang, Y., Racevskis, J., Lazarus, H. M., Rowe, J. M., Arber, D. A., Wieduwilt, M. J., Liedtke, M., Bergeron, J., Wood, B. L., Zhao, Y., Wu, G., Chang, T. C., Zhang, W., Pratz, K. W. & Dinner, S. N. & 22 others, Frey, N., Gore, S. D., Bhatnagar, B., Atallah, E. L., Uy, G. L., Jeyakumar, D., Lin, T. L., Willman, C. L., DeAngelo, D. J., Patel, S. B., Elliott, M. A., Advani, A. S., Tzachanis, D., Vachhani, P., Bhave, R. R., Sharon, E., Little, R. F., Erba, H. P., Stone, R. M., Luger, S. M., Mullighan, C. G. & Tallman, M. S., Jul 25 2024, In: New England Journal of Medicine. 391, 4, p. 320-333 14 p.

      Research output: Contribution to journal › Article › peer-review

      21 Scopus citations

    • Clinical evaluation of complete remission (CR) with partial hematologic recovery (CRh) in acute myeloid leukemia: a report of 7235 patients from seven cohorts

      Appelbaum, J. S., Wei, A. H., Mandrekar, S. J., Tiong, I. S., Chua, C. C., Teh, T. C., Fong, C. Y., Ting, S. B., Weber, D., Benner, A., Hill, H., Saadati, M., Yin, J., Stone, R. M., Garcia-Manero, G., Erba, H. P., Uy, G. L., Marcucci, G., Larson, R. A. & Thomas, A. & 9 others, Freeman, S. D., Almuina, N. M., Döhner, K., Thomas, I., Russel, N. H., Döhner, H., Othus, M., Estey, E. H. & Walter, R. B., Feb 2024, In: Leukemia. 38, 2, p. 389-392 4 p.

      Research output: Contribution to journal › Article › peer-review

      4 Scopus citations

    • Determining treatment tolerance and fitness for intensive chemotherapy in older adults with AML: a call to action

      Bhatt, V. R., Uy, G. L. & Klepin, H. D., Feb 8 2024, In: Blood. 143, 6, p. 483-487 5 p.

      Research output: Contribution to journal › Comment/debate

      6 Scopus citations

    • Follow-up from the A041202 study shows continued efficacy of ibrutinib regimens for older adults with CLL

      Woyach, J. A., Perez Burbano, G., Ruppert, A. S., Miller, C., Heerema, N. A., Zhao, W., Wall, A., Ding, W., Bartlett, N. L., Brander, D. M., Barr, P. M., Rogers, K. A., Parikh, S. A., Stephens, D. M., Brown, J. R., Lozanski, G., Blachly, J., Nattam, S., Larson, R. A. & Erba, H. & 12 others, Litzow, M., Luger, S., Owen, C., Kuzma, C., Abramson, J. S., Little, R. F., Dinner, S., Stone, R. M., Uy, G., Stock, W., Mandrekar, S. J. & Byrd, J. C., Apr 18 2024, In: Blood. 143, 16, p. 1616-1627 12 p.

      Research output: Contribution to journal › Article › peer-review

      12 Scopus citations

    • Gilteritinib as Post-Transplant Maintenance for AML with Internal Tandem Duplication Mutation of FLT3

      Levis, M. J., Hamadani, M., Logan, B., Jones, R. J., Singh, A. K., Litzow, M., Wingard, J. R., Papadopoulos, E. B., Perl, A. E., Soiffer, R. J., Ustun, C., Ueda Oshima, M., Uy, G. L., Waller, E. K., Vasu, S., Solh, M., Mishra, A., Muffly, L., Kim, H. J. & Mikesch, J. H. & 19 others, Najima, Y., Onozawa, M., Thomson, K., Nagler, A., Wei, A. H., Marcucci, G., Geller, N. L., Hasabou, N., Delgado, D., Rosales, M., Hill, J., Gill, S. C., Nuthethi, R., King, D., Wittsack, H., Mendizabal, A., Devine, S. M., Horowitz, M. M. & Chen, Y. B., May 20 2024, In: Journal of Clinical Oncology. 42, 15, p. 1766-1775 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      47 Scopus citations
    View all 152 Research outputs