Gaya Amarasinghe

2023

Real-world COVID-19 vaccine effectiveness against the Omicron BA.2 variant in a SARS-CoV-2 infection-naive population

Lau, J. J., Cheng, S. M. S., Leung, K., Lee, C. K., Hachim, A., Tsang, L. C. H., Yam, K. W. H., Chaothai, S., Kwan, K. K. H., Chai, Z. Y. H., Lo, T. H. K., Mori, M., Wu, C., Valkenburg, S. A., Amarasinghe, G. K., Lau, E. H. Y., Hui, D. S. C., Leung, G. M., Peiris, M. & Wu, J. T., Feb 2023, In: Nature medicine. 29, 2, p. 348-357 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

A cryptic pocket in Ebola VP35 allosterically controls RNA binding

Cruz, M. A., Frederick, T. E., Mallimadugula, U. L., Singh, S., Vithani, N., Zimmerman, M. I., Porter, J. R., Moeder, K. E., Amarasinghe, G. K. & Bowman, G. R., Dec 2022, In: Nature communications. 13, 1, 2269.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Antigenic landscapes on Staphylococcus aureus pore-forming toxins reveal insights into specificity and cross-neutralization

Kailasan, S., Kant, R., Noonan-Shueh, M., Kanipakala, T., Liao, G., Shulenin, S., Leung, D. W., Alm, R. A., Adhikari, R. P., Amarasinghe, G. K., Gross, M. L. & Aman, M. J., 2022, In: mAbs. 14, 1, 2083467.

Research output: Contribution to journal › Article › peer-review

Open Access

Comparison of the immunogenicity of BNT162b2 and CoronaVac COVID-19 vaccines in Hong Kong

Mok, C. K. P., Cohen, C. A., Cheng, S. M. S., Chen, C., Kwok, K. O., Yiu, K., Chan, T. O., Bull, M., Ling, K. C., Dai, Z., Ng, S. S., Lui, G. C. Y., Wu, C., Amarasinghe, G. K., Leung, D. W., Wong, S. Y. S., Valkenburg, S. A., Peiris, M. & Hui, D. S., Apr 2022, In: Respirology. 27, 4, p. 301-310 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

Cryo-EM analysis of Ebola virus nucleocapsid-like assembly

Wang, Y., Binning, J. M., Pintilie, G. D., Chiu, W., Amarasinghe, G. K., Leung, D. W. & Su, Z., Mar 18 2022, In: STAR Protocols. 3, 1, 101030.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Detection of biomarkers for filoviral infection with a silicon photonic resonator platform

Meserve, K., Qavi, A. J., Aman, M. J., Vu, H., Zeitlin, L., Dye, J. M., Froude, J. W., Leung, D. W., Yang, L., Holtsberg, F. W., Amarasinghe, G. K. & Bailey, R. C., Dec 16 2022, In: STAR Protocols. 3, 4, 101719.

Research output: Contribution to journal › Article › peer-review

Open Access

Development of Monoclonal Antibodies to Detect for SARS-CoV-2 Proteins

Mishra, N., Teyra, J., Boytz, R. M., Miersch, S., Merritt, T. N., Cardarelli, L., Gorelik, M., Mihalic, F., Jemth, P., Davey, R. A., Sidhu, S. S., Leung, D. W. & Amarasinghe, G. K., May 30 2022, In: Journal of Molecular Biology. 434, 10, 167583.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Human Metapneumovirus Phosphoprotein Independently Drives Phase Separation and Recruits Nucleoprotein to Liquid-Like Bodies

Boggs, K. B., Edmonds, K., Cifuentes-Munoz, N., Najjar, F. E., Ossandón, C., Roe, M., Wu, C., Moncman, C. L., Creamer, T. P., Amarasinghe, G. K., Leung, D. W. & Dutch, R. E., Jun 2022, In: mBio. 13, 3

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition

Ming, Q., Celias, D. P., Wu, C., Cole, A. R., Singh, S., Mason, C., Dong, S., Tran, T. H., Amarasinghe, G. K., Ruffell, B. & Luca, V. C., Jul 2022, In: Nature immunology. 23, 7, p. 1031-1041 11 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Monoclonal antibodies binding data for SARS-CoV-2 proteins

Mishra, N., Teyra, J., Boytz, R. M., Miersch, S., Merritt, T. N., Cardarelli, L., Gorelik, M., Mihalic, F., Jemth, P., Davey, R. A., Sidhu, S. S., Leung, D. W. & Amarasinghe, G. K., Aug 2022, In: Data in Brief. 43, 108415.

Research output: Contribution to journal › Article › peer-review

Open Access

Multiple genetic paths including massive gene amplification allow Mycobacterium tuberculosis to overcome loss of ESX-3 secretion system substrates

Wang, L., Asare, E., Shetty, A. C., Sanchez-Tumbaco, F., Edwards, M. R., Saranathan, R., Weinrick, B., Xu, J., Chen, B., Bénard, A., Dougan, G., Leung, D. W., Amarasinghe, G. K., Chan, J., Basler, C. F., Jacobs, W. R. & Tufariello, J. A. M., Feb 22 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 8, e2112608119.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Nipah Virus v Protein Binding Alters MDA5 Helicase Folding Dynamics

Wagner, N. D., Liu, H., Rohrs, H. W., Amarasinghe, G. K., Gross, M. L. & Leung, D. W., Jan 14 2022, In: ACS Infectious Diseases. 8, 1, p. 118-128 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1

Schwarz, M. M., Price, D. A., Ganaie, S. S., Feng, A., Mishra, N., Hoehl, R. M., Fatma, F., Stubbs, S. H., Whelan, S. P. J., Cui, X., Egawa, T., Leung, D. W., Amarasinghe, G. K. & Hartman, A. L., Aug 16 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 33, e2204706119.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Peptide-Antibody Fusions Engineered by Phage Display Exhibit an Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants

Labriola, J. M., Miersch, S., Chen, G., Chen, C., Pavlenco, A., Saberianfar, R., Caccuri, F., Zani, A., Sharma, N., Feng, A., Leung, D. W., Caruso, A., Novelli, G., Amarasinghe, G. K. & Sidhu, S. S., Jul 15 2022, In: ACS Chemical Biology. 17, 7, p. 1978-1988 11 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Plasmonic Fluor-Enhanced Antigen Arrays for High-Throughput, Serological Studies of SARS-CoV-2

Qavi, A. J., Wu, C., Lloyd, M., Zaman, M. M. U., Luan, J., Ballman, C., Leung, D. W., Crick, S. L., Farnsworth, C. W. & Amarasinghe, G. K., Aug 12 2022, In: ACS Infectious Diseases. 8, 8, p. 1468-1479 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Rapid detection of an Ebola biomarker with optical microring resonators

Qavi, A. J., Meserve, K., Aman, M. J., Vu, H., Zeitlin, L., Dye, J. M., Froude, J. W., Leung, D. W., Yang, L., Holtsberg, F. W., Bailey, R. C. & Amarasinghe, G. K., Jun 20 2022, In: Cell Reports Methods. 2, 6, 100234.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Rift Valley Fever Virus Infects the Posterior Segment of the Eye and Induces Inflammation in a Rat Model of Ocular Disease

Schwarz, M. M., Connors, K. A., Davoli, K. A., McMillen, C. M., Albe, J. R., Hoehl, R. M., Demers, M. J., Ganaie, S. S., Price, D. A., Leung, D. W., Amarasinghe, G. K., McElroy, A. K., Reed, D. S. & Hartman, A. L., Oct 2022, In: Journal of virology. 96, 20

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

SARS-CoV-2 accessory proteins reveal distinct serological signatures in children

Hachim, A., Gu, H., Kavian, O., Mori, M., Kwan, M. Y. W., Chan, W. H., Yau, Y. S., Chiu, S. S., Tsang, O. T. Y., Hui, D. S. C., Mok, C. K. P., Ma, F. N. L., Lau, E. H. Y., Amarasinghe, G. K., Qavi, A. J., Cheng, S. M. S., Poon, L. L. M., Peiris, J. S. M., Valkenburg, S. A. & Kavian, N., Dec 2022, In: Nature communications. 13, 1, 2951.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment

Huang, Z., Liu, H., Nix, J., Xu, R., Knoverek, C. R., Bowman, G. R., Amarasinghe, G. K. & Sibley, L. D., Dec 2022, In: Nature communications. 13, 1, 4047.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site

van Vliet, V. J. E., Huynh, N., Palà, J., Patel, A., Singer, A., Slater, C., Chung, J., van Huizen, M., Teyra, J., Miersch, S., Luu, G. K., Ye, W., Sharma, N., Ganaie, S. S., Russell, R., Chen, C., Maynard, M., Amarasinghe, G. K., Mark, B. L., Kikkert, M., & 1 othersSidhu, S. S., Dec 2022, In: PLoS pathogens. 18, 12, e1011065.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Ultrapotent and broad neutralization of SARS-CoV-2 variants by modular, tetravalent, bi-paratopic antibodies

Miersch, S., Sharma, N., Saberianfar, R., Chen, C., Caccuri, F., Zani, A., Caruso, A., Case, J. B., Diamond, M. S., Amarasinghe, G. K., Novelli, G. & Sidhu, S. S., May 31 2022, In: Cell Reports. 39, 9, 110905.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2021

2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Kuhn, J. H., Adkins, S., Agwanda, B. R., Al Kubrusli, R., Alkhovsky, S. V., Amarasinghe, G. K., Avšič-Županc, T., Ayllón, M. A., Bahl, J., Balkema-Buschmann, A., Ballinger, M. J., Basler, C. F., Bavari, S., Beer, M., Bejerman, N., Bennett, A. J., Bente, D. A., Bergeron, É., Bird, B. H., Blair, C. D., & 231 othersBlasdell, K. R., Blystad, D. R., Bojko, J., Borth, W. B., Bradfute, S., Breyta, R., Briese, T., Brown, P. A., Brown, J. K., Buchholz, U. J., Buchmeier, M. J., Bukreyev, A., Burt, F., Büttner, C., Calisher, C. H., Cao, M., Casas, I., Chandran, K., Charrel, R. N., Cheng, Q., Chiaki, Y., Chiapello, M., Choi, I. R., Ciuffo, M., Clegg, J. C. S., Crozier, I., Dal Bó, E., de la Torre, J. C., de Lamballerie, X., de Swart, R. L., Debat, H., Dheilly, N. M., Di Cicco, E., Di Paola, N., Di Serio, F., Dietzgen, R. G., Digiaro, M., Dolnik, O., Drebot, M. A., Drexler, J. F., Dundon, W. G., Duprex, W. P., Dürrwald, R., Dye, J. M., Easton, A. J., Ebihara, H., Elbeaino, T., Ergünay, K., Ferguson, H. W., Fooks, A. R., Forgia, M., Formenty, P. B. H., Fránová, J., Freitas-Astúa, J., Fu, J., Fürl, S., Gago-Zachert, S., Gāo, G. F., García, M. L., García-Sastre, A., Garrison, A. R., Gaskin, T., Gonzalez, J. P. J., Griffiths, A., Goldberg, T. L., Groschup, M. H., Günther, S., Hall, R. A., Hammond, J., Han, T., Hepojoki, J., Hewson, R., Hong, J., Hong, N., Hongo, S., Horie, M., Hu, J. S., Hu, T., Hughes, H. R., Hüttner, F., Hyndman, T. H., Ilyas, M., Jalkanen, R., Jiāng, D., Jonson, G. B., Junglen, S., Kadono, F., Kaukinen, K. H., Kawate, M., Klempa, B., Klingström, J., Kobinger, G., Koloniuk, I., Kondō, H., Koonin, E. V., Krupovic, M., Kubota, K., Kurath, G., Laenen, L., Lambert, A. J., Langevin, S. L., Lee, B., Lefkowitz, E. J., Leroy, E. M., Li, S., Li, L., Lǐ, J., Liu, H., Lukashevich, I. S., Maes, P., de Souza, W. M., Marklewitz, M., Marshall, S. H., Marzano, S. Y. L., Massart, S., McCauley, J. W., Melzer, M., Mielke-Ehret, N., Miller, K. M., Ming, T. J., Mirazimi, A., Mordecai, G. J., Mühlbach, H. P., Mühlberger, E., Naidu, R., Natsuaki, T., Navarro, J. A., Netesov, S. V., Neumann, G., Nowotny, N., Nunes, M. R. T., Olmedo-Velarde, A., Palacios, G., Pallás, V., Pályi, B., Papa, A., Paraskevopoulou, S., Park, A. C., Parrish, C. R., Patterson, D. A., Pauvolid-Corrêa, A., Pawęska, J. T., Payne, S., Peracchio, C., Pérez, D. R., Postler, T. S., Qi, L., Radoshitzky, S. R., Resende, R. O., Reyes, C. A., Rima, B. K., Luna, G. R., Romanowski, V., Rota, P., Rubbenstroth, D., Rubino, L., Runstadler, J. A., Sabanadzovic, S., Sall, A. A., Salvato, M. S., Sang, R., Sasaya, T., Schulze, A. D., Schwemmle, M., Shi, M., Shí, X., Shí, Z., Shimomoto, Y., Shirako, Y., Siddell, S. G., Simmonds, P., Sironi, M., Smagghe, G., Smither, S., Song, J. W., Spann, K., Spengler, J. R., Stenglein, M. D., Stone, D. M., Sugano, J., Suttle, C. A., Tabata, A., Takada, A., Takeuchi, S., Tchouassi, D. P., Teffer, A., Tesh, R. B., Thornburg, N. J., Tomitaka, Y., Tomonaga, K., Tordo, N., Torto, B., Towner, J. S., Tsuda, S., Tu, C., Turina, M., Tzanetakis, I. E., Uchida, J., Usugi, T., Vaira, A. M., Vallino, M., van den Hoogen, B., Varsani, A., Vasilakis, N., Verbeek, M., von Bargen, S., Wada, J., Wahl, V., Walker, P. J., Wang, L. F., Wang, G., Wang, Y., Wang, Y., Waqas, M., Wèi, T., Wen, S., Whitfield, A. E., Williams, J. V., Wolf, Y. I., Wu, J., Xu, L., Yanagisawa, H., Yang, C., Yang, Z., Zerbini, F. M., Zhai, L., Zhang, Y. Z., Zhang, S., Zhang, J., Zhang, Z. & Zhou, X., Dec 2021, In: Archives of Virology. 166, 12, p. 3513-3566 54 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Characterization of SARS-CoV-2 nucleocapsid protein reveals multiple functional consequences of the C-terminal domain

Wu, C., Qavi, A. J., Hachim, A., Kavian, N., Cole, A. R., Moyle, A. B., Wagner, N. D., Sweeney-Gibbons, J., Rohrs, H. W., Gross, M. L., Peiris, J. S. M., Basler, C. F., Farnsworth, C. W., Valkenburg, S. A., Amarasinghe, G. K. & Leung, D. W., Jun 25 2021, In: iScience. 24, 6, 102681.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Domain-specific biochemical and serological characterization of SARS-CoV-2 nucleocapsid protein

Wu, C., Qavi, A. J., Moyle, A. B., Wagner, N. D., Hachim, A., Kavian, N., Cole, A. R., Sweeney-Gibbons, J., Rohrs, H. W., Peiris, J. S. M., Basler, C. F., Gross, M. L., Valkenburg, S. A., Farnsworth, C. W., Amarasinghe, G. K. & Leung, D. W., Dec 17 2021, In: STAR Protocols. 2, 4, 100906.

Research output: Contribution to journal › Article › peer-review

Open Access

Itaconate confers tolerance to late NLRP3 inflammasome activation

Bambouskova, M., Potuckova, L., Paulenda, T., Kerndl, M., Mogilenko, D. A., Lizotte, K., Swain, A., Hayes, S., Sheldon, R. D., Kim, H., Kapadnis, U., Ellis, A. E., Isaguirre, C., Burdess, S., Laha, A., Amarasinghe, G. K., Chubukov, V., Roddy, T. P., Diamond, M. S., Jones, R. G., & 2 othersSimons, D. M. & Artyomov, M. N., Mar 9 2021, In: Cell Reports. 34, 10, 108756.

Research output: Contribution to journal › Article › peer-review

Open Access

62 Scopus citations

Lrp1 is a host entry factor for Rift Valley fever virus

Ganaie, S. S., Schwarz, M. M., McMillen, C. M., Price, D. A., Feng, A. X., Albe, J. R., Wang, W., Miersch, S., Orvedahl, A., Cole, A. R., Sentmanat, M. F., Mishra, N., Boyles, D. A., Koenig, Z. T., Kujawa, M. R., Demers, M. A., Hoehl, R. M., Moyle, A. B., Wagner, N. D., Stubbs, S. H., & 14 othersCardarelli, L., Teyra, J., McElroy, A., Gross, M. L., Whelan, S. P. J., Doench, J., Cui, X., Brett, T. J., Sidhu, S. S., Virgin, H. W., Egawa, T., Leung, D. W., Amarasinghe, G. K. & Hartman, A. L., Sep 30 2021, In: Cell. 184, 20, p. 5163-5178.e24

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Non-canonical proline-tyrosine interactions with multiple host proteins regulate Ebola virus infection

Batra, J., Mori, H., Small, G. I., Anantpadma, M., Shtanko, O., Mishra, N., Zhang, M., Liu, D., Williams, C. G., Biedenkopf, N., Becker, S., Gross, M. L., Leung, D. W., Davey, R. A., Amarasinghe, G. K., Krogan, N. J. & Basler, C. F., Sep 15 2021, In: EMBO Journal. 40, 18, e105658.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription

Pei, J., Beri, N. R., Zou, A. J., Hubel, P., Dorando, H. K., Bergant, V., Andrews, R. D., Pan, J., Andrews, J. M., Sheehan, K. C. F., Pichlmair, A., Amarasinghe, G. K., Brody, S. L., Payton, J. E. & Leung, D. W., Oct 12 2021, In: Cell Reports. 37, 2, 109803.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2

Pei, J., Wagner, N. D., Zou, A. J., Chatterjee, S., Borek, D., Cole, A. R., Kim, P. J., Basler, C. F., Otwinowski, Z., Gross, M. L., Amarasinghe, G. K. & Leung, D. W., Mar 9 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 10, e2020587118.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations

Miersch, S., Li, Z., Saberianfar, R., Ustav, M., Brett Case, J., Blazer, L., Chen, C., Ye, W., Pavlenco, A., Gorelik, M., Garcia Perez, J., Subramania, S., Singh, S., Ploder, L., Ganaie, S., Chen, R. E., Leung, D. W., Pandolfi, P. P., Novelli, G., Matusali, G., & 8 othersColavita, F., Capobianchi, M. R., Jain, S., Gupta, J. B., Amarasinghe, G. K., Diamond, M. S., Rini, J. & Sidhu, S. S., Sep 17 2021, In: Journal of Molecular Biology. 433, 19, 167177.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

2020

2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Kuhn, J. H., Adkins, S., Alioto, D., Alkhovsky, S. V., Amarasinghe, G. K., Anthony, S. J., Avšič-Županc, T., Ayllón, M. A., Bahl, J., Balkema-Buschmann, A., Ballinger, M. J., Bartonička, T., Basler, C., Bavari, S., Beer, M., Bente, D. A., Bergeron, É., Bird, B. H., Blair, C., Blasdell, K. R., & 209 othersBradfute, S. B., Breyta, R., Briese, T., Brown, P. A., Buchholz, U. J., Buchmeier, M. J., Bukreyev, A., Burt, F., Buzkan, N., Calisher, C. H., Cao, M., Casas, I., Chamberlain, J., Chandran, K., Charrel, R. N., Chen, B., Chiumenti, M., Choi, I. R., Clegg, J. C. S., Crozier, I., da Graça, J. V., Dal Bó, E., Dávila, A. M. R., de la Torre, J. C., de Lamballerie, X., de Swart, R. L., Di Bello, P. L., Di Paola, N., Di Serio, F., Dietzgen, R. G., Digiaro, M., Dolja, V. V., Dolnik, O., Drebot, M. A., Drexler, J. F., Dürrwald, R., Dufkova, L., Dundon, W. G., Duprex, W. P., Dye, J. M., Easton, A. J., Ebihara, H., Elbeaino, T., Ergünay, K., Fernandes, J., Fooks, A. R., Formenty, P. B. H., Forth, L. F., Fouchier, R. A. M., Freitas-Astúa, J., Gago-Zachert, S., Gāo, G. F., García, M. L., García-Sastre, A., Garrison, A. R., Gbakima, A., Goldstein, T., Gonzalez, J. P. J., Griffiths, A., Groschup, M. H., Günther, S., Guterres, A., Hall, R. A., Hammond, J., Hassan, M., Hepojoki, J., Hepojoki, S., Hetzel, U., Hewson, R., Hoffmann, B., Hongo, S., Höper, D., Horie, M., Hughes, H. R., Hyndman, T. H., Jambai, A., Jardim, R., Jiāng, D., Jin, Q., Jonson, G. B., Junglen, S., Karadağ, S., Keller, K. E., Klempa, B., Klingström, J., Kobinger, G., Kondō, H., Koonin, E. V., Krupovic, M., Kurath, G., Kuzmin, I. V., Laenen, L., Lamb, R. A., Lambert, A. J., Langevin, S. L., Lee, B., Lemos, E. R. S., Leroy, E. M., Li, D., Lǐ, J., Liang, M., Liú, W., Liú, Y., Lukashevich, I. S., Maes, P., Marciel de Souza, W., Marklewitz, M., Marshall, S. H., Martelli, G. P., Martin, R. R., Marzano, S. Y. L., Massart, S., McCauley, J. W., Mielke-Ehret, N., Minafra, A., Minutolo, M., Mirazimi, A., Mühlbach, H. P., Mühlberger, E., Naidu, R., Natsuaki, T., Navarro, B., Navarro, J. A., Netesov, S. V., Neumann, G., Nowotny, N., Nunes, M. R. T., Nylund, A., Økland, A. L., Oliveira, R. C., Palacios, G., Pallas, V., Pályi, B., Papa, A., Parrish, C. R., Pauvolid-Corrêa, A., Pawęska, J. T., Payne, S., Pérez, D. R., Pfaff, F., Radoshitzky, S. R., Rahman, A. U., Ramos-González, P. L., Resende, R. O., Reyes, C. A., Rima, B. K., Romanowski, V., Robles Luna, G., Rota, P., Rubbenstroth, D., Runstadler, J. A., Ruzek, D., Sabanadzovic, S., Salát, J., Sall, A. A., Salvato, M. S., Sarpkaya, K., Sasaya, T., Schwemmle, M., Shabbir, M. Z., Shí, X., Shí, Z., Shirako, Y., Simmonds, P., Širmarová, J., Sironi, M., Smither, S., Smura, T., Song, J. W., Spann, K. M., Spengler, J. R., Stenglein, M. D., Stone, D. M., Straková, P., Takada, A., Tesh, R. B., Thornburg, N. J., Tomonaga, K., Tordo, N., Towner, J. S., Turina, M., Tzanetakis, I., Ulrich, R. G., Vaira, A. M., van den Hoogen, B., Varsani, A., Vasilakis, N., Verbeek, M., Wahl, V., Walker, P. J., Wang, H., Wang, J., Wang, X., Wang, L. F., Wèi, T., Wells, H., Whitfield, A. E., Williams, J. V., Wolf, Y. I., Wú, Z., Yang, X., Yáng, X., Yu, X., Yutin, N., Zerbini, F. M., Zhang, T., Zhang, Y. Z., Zhou, G. & Zhou, X., Dec 1 2020, In: Archives of Virology. 165, 12, p. 3023-3072 50 p.

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127 Scopus citations

Fragment screening targeting Ebola virus nucleoprotein C-terminal domain identifies lead candidates

Aceti, D. J., Ahmed, H., Westler, W. M., Wu, C., Dashti, H., Tonelli, M., Eghbalnia, H., Amarasinghe, G. K. & Markley, J. L., Aug 2020, In: Antiviral Research. 180, 104822.

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1 Scopus citations

Global phosphoproteomic analysis of Ebola virions reveals a novel role for VP35 phosphorylation-dependent regulation of genome transcription

Ivanov, A., Ramanathan, P., Parry, C., Ilinykh, P. A., Lin, X., Petukhov, M., Obukhov, Y., Ammosova, T., Amarasinghe, G. K., Bukreyev, A. & Nekhai, S., Jul 1 2020, In: Cellular and Molecular Life Sciences. 77, 13, p. 2579-2603 25 p.

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8 Scopus citations

Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2

Case, J. B., Rothlauf, P. W., Chen, R. E., Liu, Z., Zhao, H., Kim, A. S., Bloyet, L. M., Zeng, Q., Tahan, S., Droit, L., Ilagan, M. X. G., Tartell, M. A., Amarasinghe, G., Henderson, J. P., Miersch, S., Ustav, M., Sidhu, S., Virgin, H. W., Wang, D., Ding, S., & 5 othersCorti, D., Theel, E. S., Fremont, D. H., Diamond, M. S. & Whelan, S. P. J., Sep 9 2020, In: Cell Host and Microbe. 28, 3, p. 475-485.e5

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213 Scopus citations

Small Molecule Compounds That Inhibit Antioxidant Response Gene Expression in an Inducer-Dependent Manner

Edwards, M. R., Liu, G., De, S., Sourimant, J., Pietzsch, C., Johnson, B., Amarasinghe, G. K., Leung, D. W., Bukreyev, A., Plemper, R. K., Aron, Z., Bowlin, T. L., Moir, D. T. & Basler, C. F., Mar 13 2020, In: ACS Infectious Diseases. 6, 3, p. 489-502 14 p.

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1 Scopus citations

The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target

Wang, W., Shin, W. J., Zhang, B., Choi, Y., Yoo, J. S., Zimmerman, M. I., Frederick, T. E., Bowman, G. R., Gross, M. L., Leung, D. W., Jung, J. U. & Amarasinghe, G. K., Jan 7 2020, In: Cell Reports. 30, 1, p. 153-163.e5

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18 Scopus citations

2019

A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis

Lee, S., Liu, H., Wilen, C. B., Sychev, Z. E., Desai, C., Hykes, B. L., Orchard, R. C., McCune, B. T., Kim, K. W., Nice, T. J., Handley, S. A., Baldridge, M. T., Amarasinghe, G. K. & Virgin, H. W., Jun 12 2019, In: Cell Host and Microbe. 25, 6, p. 845-857.e5

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43 Scopus citations

Backbone resonance assignments and secondary structure of Ebola nucleoprotein 600–739 construct

Lee, W., Tonelli, M., Wu, C., Aceti, D. J., Amarasinghe, G. K. & Markley, J. L., Oct 15 2019, In: Biomolecular NMR Assignments. 13, 2, p. 315-319 5 p.

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2 Scopus citations

ICTV virus taxonomy profile: Filoviridae

ICTV Report Consortium, Jun 2019, In: Journal of General Virology. 100, 6, p. 911-912 2 p.

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46 Scopus citations

Potent Neutralization of Staphylococcal Enterotoxin B In Vivo by Antibodies that Block Binding to the T-Cell Receptor

Chen, G., Karauzum, H., Long, H., Carranza, D., Holtsberg, F. W., Howell, K. A., Abaandou, L., Zhang, B., Jarvik, N., Ye, W., Liao, G. C., Gross, M. L., Leung, D. W., Amarasinghe, G. K., Aman, M. J. & Sidhu, S. S., Oct 4 2019, In: Journal of Molecular Biology. 431, 21, p. 4354-4367 14 p.

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12 Scopus citations

Taxonomy of the order Mononegavirales: second update 2018

Maes, P., Amarasinghe, G. K., Ayllón, M. A., Basler, C. F., Bavari, S., Blasdell, K. R., Briese, T., Brown, P. A., Bukreyev, A., Balkema-Buschmann, A., Buchholz, U. J., Chandran, K., Crozier, I., de Swart, R. L., Dietzgen, R. G., Dolnik, O., Domier, L. L., Drexler, J. F., Dürrwald, R., Dundon, W. G., & 57 othersDuprex, W. P., Dye, J. M., Easton, A. J., Fooks, A. R., Formenty, P. B. H., Fouchier, R. A. M., Freitas-Astúa, J., Ghedin, E., Griffiths, A., Hewson, R., Horie, M., Hurwitz, J. L., Hyndman, T. H., Jiāng, D., Kobinger, G. P., Kondō, H., Kurath, G., Kuzmin, I. V., Lamb, R. A., Lee, B., Leroy, E. M., Lǐ, J., Marzano, S. Y. L., Mühlberger, E., Netesov, S. V., Nowotny, N., Palacios, G., Pályi, B., Pawęska, J. T., Payne, S. L., Rima, B. K., Rota, P., Rubbenstroth, D., Simmonds, P., Smither, S. J., Song, Q., Song, T., Spann, K., Stenglein, M. D., Stone, D. M., Takada, A., Tesh, R. B., Tomonaga, K., Tordo, N., Towner, J. S., van den Hoogen, B., Vasilakis, N., Wahl, V., Walker, P. J., Wang, D., Wang, L. F., Whitfield, A. E., Williams, J. V., Yè, G., Zerbini, F. M., Zhang, Y. Z. & Kuhn, J. H., Apr 3 2019, In: Archives of Virology. 164, 4, p. 1233-1244 12 p.

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67 Scopus citations

Taxonomy of the order Mononegavirales: update 2019

Amarasinghe, G. K., Ayllón, M. A., Bào, Y., Basler, C. F., Bavari, S., Blasdell, K. R., Briese, T., Brown, P. A., Bukreyev, A., Balkema-Buschmann, A., Buchholz, U. J., Chabi-Jesus, C., Chandran, K., Chiapponi, C., Crozier, I., de Swart, R. L., Dietzgen, R. G., Dolnik, O., Drexler, J. F., Dürrwald, R., & 64 othersDundon, W. G., Duprex, W. P., Dye, J. M., Easton, A. J., Fooks, A. R., Formenty, P. B. H., Fouchier, R. A. M., Freitas-Astúa, J., Griffiths, A., Hewson, R., Horie, M., Hyndman, T. H., Jiāng, D., Kitajima, E. W., Kobinger, G. P., Kondō, H., Kurath, G., Kuzmin, I. V., Lamb, R. A., Lavazza, A., Lee, B., Lelli, D., Leroy, E. M., Lǐ, J., Maes, P., Marzano, S. Y. L., Moreno, A., Mühlberger, E., Netesov, S. V., Nowotny, N., Nylund, A., Økland, A. L., Palacios, G., Pályi, B., Pawęska, J. T., Payne, S. L., Prosperi, A., Ramos-González, P. L., Rima, B. K., Rota, P., Rubbenstroth, D., Shī, M., Simmonds, P., Smither, S. J., Sozzi, E., Spann, K., Stenglein, M. D., Stone, D. M., Takada, A., Tesh, R. B., Tomonaga, K., Tordo, N., Towner, J. S., van den Hoogen, B., Vasilakis, N., Wahl, V., Walker, P. J., Wang, L. F., Whitfield, A. E., Williams, J. V., Zerbini, F. M., Zhāng, T., Zhang, Y. Z. & Kuhn, J. H., Jul 1 2019, In: Archives of Virology. 164, 7, p. 1967-1980 14 p.

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178 Scopus citations

2018

Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange

Johnson, B., McConnell, P., Kozlov, A. G., Mekel, M., Lohman, T. M., Gross, M. L., Amarasinghe, G. K. & Cooper, J. A., May 29 2018, In: Cell Reports. 23, 9, p. 2795-2804 10 p.

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11 Scopus citations

A novel mode of capping protein-regulation by twinfilin

Johnston, A. B., Hilton, D. M., McConnell, P., Johnson, B., Harris, M. T., Simone, A., Amarasinghe, G. K., Cooper, J. A. & Goode, B. L., Oct 2018, In: eLife. 7, e41313.

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24 Scopus citations

Applications of Parametrized NMR Spin Systems of Small Molecules

Dashti, H., Wedell, J. R., Westler, W. M., Tonelli, M., Aceti, D., Amarasinghe, G. K., Markley, J. L. & Eghbalnia, H. R., Sep 18 2018, In: Analytical Chemistry. 90, 18, p. 10646-10649 4 p.

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18 Scopus citations

Conservation of Structure and Immune Antagonist Functions of Filoviral VP35 Homologs Present in Microbat Genomes

Edwards, M. R., Liu, H., Shabman, R. S., Ginell, G. M., Luthra, P., Ramanan, P., Keefe, L. J., Köllner, B., Amarasinghe, G. K., Taylor, D. J., Leung, D. W. & Basler, C. F., Jul 24 2018, In: Cell Reports. 24, 4, p. 861-872.e6

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11 Scopus citations

Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly

Su, Z., Wu, C., Shi, L., Luthra, P., Pintilie, G. D., Johnson, B., Porter, J. R., Ge, P., Chen, M., Liu, G., Frederick, T. E., Binning, J. M., Bowman, G. R., Zhou, Z. H., Basler, C. F., Gross, M. L., Leung, D. W., Chiu, W. & Amarasinghe, G. K., Feb 22 2018, In: Cell. 172, 5, p. 966-978.e12

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39 Scopus citations

Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis

Bambouskova, M., Gorvel, L., Lampropoulou, V., Sergushichev, A., Loginicheva, E., Johnson, K., Korenfeld, D., Mathyer, M. E., Kim, H., Huang, L. H., Duncan, D., Bregman, H., Keskin, A., Santeford, A., Apte, R. S., Sehgal, R., Johnson, B., Amarasinghe, G. K., Soares, M. P., Satoh, T., & 11 othersAkira, S., Hai, T., De Guzman Strong, C., Auclair, K., Roddy, T. P., Biller, S. A., Jovanovic, M., Klechevsky, E., Stewart, K. M., Randolph, G. J. & Artyomov, M. N., Apr 26 2018, In: Nature. 556, 7702, p. 501-504 4 p.

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337 Scopus citations

Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability

Johnson, B., VanBlargan, L. A., Xu, W., White, J. P., Shan, C., Shi, P. Y., Zhang, R., Adhikari, J., Gross, M. L., Leung, D. W., Diamond, M. S. & Amarasinghe, G. K., Mar 20 2018, In: Immunity. 48, 3, p. 487-499.e5

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60 Scopus citations

LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens

Yokoyama, C. C., Baldridge, M. T., Leung, D. W., Zhao, G., Desai, C., Liu, T. C., Diaz-Ochoa, V. E., Huynh, J. P., Kimmey, J. M., Sennott, E. L., Hole, C. R., Idol, R. A., Park, S., Storek, K. M., Wang, C., Hwang, S., Milam, A. V., Chen, E., Kerrinnes, T., Starnbach, M. N., & 12 othersHandley, S. A., Mysorekar, I. U., Allen, P. M., Monack, D. M., Dinauer, M. C., Doering, T. L., Tsolis, R. M., Dworkin, J. E., Stallings, C. L., Amarasinghe, G. K., Micchelli, C. A. & Virgina, H. W., Apr 20 2018, In: Journal of Biological Chemistry. 293, 16, p. 6022-6038 17 p.

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6 Scopus citations

Gaya Amarasinghe

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