Gaya Amarasinghe

Professor of Pathology and Immunology, Professor of Biochemistry and Molecular Biophysics, Professor of Molecular Microbiology

    • Source: Scopus
    20002021

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    Research interests

    The innate immune system serves as a first line of defense against viral infections. Germline encoded pattern recognition receptors detect pathogens and promote innate immune responses, including activation of type I interferons (IFNs) and stimulation of antiviral genes. In addition to limiting infections, innate immunity is required to activate humoral responses and to develop long-term protection via adaptive immune response. Dysregulation of IFN signaling is detrimental to the host, resulting in events such as cytokine storms during infections or autoimmune disorders.

    In my laboratory, we use a multidisciplinary research program that spans length and time scales to address this question by characterizing the molecular mechanisms of initial interactions at the host-pathogen interface. Using this information, we expect to develop a framework to manipulate viruses by modulating virulence (less virulent) in order to gain insight into immune mechanisms that are at play during these critical time points. Our current efforts are aimed toward defining the molecular basis for viral hemorrhagic fever (VHF) at the host-viral interface. VHF is a complex multivariable challenge with contributions from the virus and from the host dictating the outcome. We have begun a series of studies to understand the viral components, host factors and their interactions between each other. Below I briefly describe recent and recently completed studies that provide the experimental framework for us to examine these questions.

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    • Characterization of SARS-CoV-2 nucleocapsid protein reveals multiple functional consequences of the C-terminal domain

      Wu, C., Qavi, A. J., Hachim, A., Kavian, N., Cole, A. R., Moyle, A. B., Wagner, N. D., Sweeney-Gibbons, J., Rohrs, H. W., Gross, M. L., Peiris, J. S. M., Basler, C. F., Farnsworth, C. W., Valkenburg, S. A., Amarasinghe, G. K. & Leung, D. W., Jun 25 2021, In: iScience. 24, 6, 102681.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      1 Scopus citations
    • Itaconate confers tolerance to late NLRP3 inflammasome activation

      Bambouskova, M., Potuckova, L., Paulenda, T., Kerndl, M., Mogilenko, D. A., Lizotte, K., Swain, A., Hayes, S., Sheldon, R. D., Kim, H., Kapadnis, U., Ellis, A. E., Isaguirre, C., Burdess, S., Laha, A., Amarasinghe, G. K., Chubukov, V., Roddy, T. P., Diamond, M. S., Jones, R. G. & 2 others, Simons, D. M. & Artyomov, M. N., Mar 9 2021, In: Cell Reports. 34, 10, 108756.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      9 Scopus citations
    • Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription

      Pei, J., Beri, N. R., Zou, A. J., Hubel, P., Dorando, H. K., Bergant, V., Andrews, R. D., Pan, J., Andrews, J. M., Sheehan, K. C. F., Pichlmair, A., Amarasinghe, G. K., Brody, S. L., Payton, J. E. & Leung, D. W., Oct 12 2021, In: Cell Reports. 37, 2, 109803.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2

      Pei, J., Wagner, N. D., Zou, A. J., Chatterjee, S., Borek, D., Cole, A. R., Kim, P. J., Basler, C. F., Otwinowski, Z., Gross, M. L., Amarasinghe, G. K. & Leung, D. W., Mar 9 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 10, e2020587118.

      Research output: Contribution to journalArticlepeer-review

      1 Scopus citations
    • 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

      Kuhn, J. H., Adkins, S., Alioto, D., Alkhovsky, S. V., Amarasinghe, G. K., Anthony, S. J., Avšič-Županc, T., Ayllón, M. A., Bahl, J., Balkema-Buschmann, A., Ballinger, M. J., Bartonička, T., Basler, C., Bavari, S., Beer, M., Bente, D. A., Bergeron, É., Bird, B. H., Blair, C., Blasdell, K. R. & 209 others, Bradfute, S. B., Breyta, R., Briese, T., Brown, P. A., Buchholz, U. J., Buchmeier, M. J., Bukreyev, A., Burt, F., Buzkan, N., Calisher, C. H., Cao, M., Casas, I., Chamberlain, J., Chandran, K., Charrel, R. N., Chen, B., Chiumenti, M., Choi, I. R., Clegg, J. C. S., Crozier, I., da Graça, J. V., Dal Bó, E., Dávila, A. M. R., de la Torre, J. C., de Lamballerie, X., de Swart, R. L., Di Bello, P. L., Di Paola, N., Di Serio, F., Dietzgen, R. G., Digiaro, M., Dolja, V. V., Dolnik, O., Drebot, M. A., Drexler, J. F., Dürrwald, R., Dufkova, L., Dundon, W. G., Duprex, W. P., Dye, J. M., Easton, A. J., Ebihara, H., Elbeaino, T., Ergünay, K., Fernandes, J., Fooks, A. R., Formenty, P. B. H., Forth, L. F., Fouchier, R. A. M., Freitas-Astúa, J., Gago-Zachert, S., Gāo, G. F., García, M. L., García-Sastre, A., Garrison, A. R., Gbakima, A., Goldstein, T., Gonzalez, J. P. J., Griffiths, A., Groschup, M. H., Günther, S., Guterres, A., Hall, R. A., Hammond, J., Hassan, M., Hepojoki, J., Hepojoki, S., Hetzel, U., Hewson, R., Hoffmann, B., Hongo, S., Höper, D., Horie, M., Hughes, H. R., Hyndman, T. H., Jambai, A., Jardim, R., Jiāng, D., Jin, Q., Jonson, G. B., Junglen, S., Karadağ, S., Keller, K. E., Klempa, B., Klingström, J., Kobinger, G., Kondō, H., Koonin, E. V., Krupovic, M., Kurath, G., Kuzmin, I. V., Laenen, L., Lamb, R. A., Lambert, A. J., Langevin, S. L., Lee, B., Lemos, E. R. S., Leroy, E. M., Li, D., Lǐ, J., Liang, M., Liú, W., Liú, Y., Lukashevich, I. S., Maes, P., Marciel de Souza, W., Marklewitz, M., Marshall, S. H., Martelli, G. P., Martin, R. R., Marzano, S. Y. L., Massart, S., McCauley, J. W., Mielke-Ehret, N., Minafra, A., Minutolo, M., Mirazimi, A., Mühlbach, H. P., Mühlberger, E., Naidu, R., Natsuaki, T., Navarro, B., Navarro, J. A., Netesov, S. V., Neumann, G., Nowotny, N., Nunes, M. R. T., Nylund, A., Økland, A. L., Oliveira, R. C., Palacios, G., Pallas, V., Pályi, B., Papa, A., Parrish, C. R., Pauvolid-Corrêa, A., Pawęska, J. T., Payne, S., Pérez, D. R., Pfaff, F., Radoshitzky, S. R., Rahman, A. U., Ramos-González, P. L., Resende, R. O., Reyes, C. A., Rima, B. K., Romanowski, V., Robles Luna, G., Rota, P., Rubbenstroth, D., Runstadler, J. A., Ruzek, D., Sabanadzovic, S., Salát, J., Sall, A. A., Salvato, M. S., Sarpkaya, K., Sasaya, T., Schwemmle, M., Shabbir, M. Z., Shí, X., Shí, Z., Shirako, Y., Simmonds, P., Širmarová, J., Sironi, M., Smither, S., Smura, T., Song, J. W., Spann, K. M., Spengler, J. R., Stenglein, M. D., Stone, D. M., Straková, P., Takada, A., Tesh, R. B., Thornburg, N. J., Tomonaga, K., Tordo, N., Towner, J. S., Turina, M., Tzanetakis, I., Ulrich, R. G., Vaira, A. M., van den Hoogen, B., Varsani, A., Vasilakis, N., Verbeek, M., Wahl, V., Walker, P. J., Wang, H., Wang, J., Wang, X., Wang, L. F., Wèi, T., Wells, H., Whitfield, A. E., Williams, J. V., Wolf, Y. I., Wú, Z., Yang, X., Yáng, X., Yu, X., Yutin, N., Zerbini, F. M., Zhang, T., Zhang, Y. Z., Zhou, G. & Zhou, X., Dec 1 2020, In: Archives of Virology. 165, 12, p. 3023-3072 50 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      52 Scopus citations