Gavin Dunn

Associate Professor of Neurological Surgery, Associate Professor of Pathology and Immunology, Associate Professor of Neurology

    • 13357 Citations

    Research output per year

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    Personal profile

    Research interests

    Whereas extensive genomic profiling is uncovering tumor cell vulnerabilities across many cancer types, this paradigm has not extended to glioblastoma due, at least in part, to the tremendous heterogeneity within these tumors. In contrast to conventional targeted therapeutic approaches, immune-based strategies may be particularly well-suited to treating these tumors due to the incredible diversity of antigens recognizable by immune cells. My laboratory is focused on understanding the molecular and cellular basis of the immune response to glioblastoma in preclinical and translational settings as well as clarifying the relationships between glioma genomics and immunogenicity, an area termed “cancer immunogenomics.” These investigations are complemented by ongoing clinical trial efforts in this area.

    Areas of Clinical Interest

    Brain tumors, including glioma, astrocytoma, oligodendroglioma, glioblastoma; ependymoma, meningioma, metastatic brain tumors; neuro-oncology; Chiari malformation; hydrocephalus, including endoscopic third ventriculostomy; trigeminal neuralgia

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    Research Output

    A Multi-Institutional Analysis of Factors Influencing Surgical Outcomes for Patients with Newly Diagnosed Grade I Gliomas

    Yahanda, A. T., Patel, B., Sutherland, G., Honeycutt, J., Jensen, R. L., Smyth, M. D., Limbrick, D. D., Dacey, R. G., Dowling, J. L., Dunn, G. P., Kim, A. H., Leuthardt, E. C., Rich, K. M., Zipfel, G. J., Leonard, J. R., Cahill, D. P., Shah, M. V., Abram, S. R., Evans, J., Tao, Y. & 1 others, Chicoine, M. R., Mar 2020, In : World neurosurgery. 135, p. e754-e764

    Research output: Contribution to journalArticle

  • A review of glioblastoma immunotherapy

    Medikonda, R., Dunn, G., Rahman, M., Fecci, P. & Lim, M., Jan 1 2020, (Accepted/In press) In : Journal of Neuro-Oncology.

    Research output: Contribution to journalReview article

  • 1 Scopus citations

    Consensus recommendations for a standardized brain tumor imaging protocol for clinical trials in brain metastases

    Kaufmann, T. J., Smits, M., Boxerman, J., Huang, R., Barboriak, D. P., Weller, M., Chung, C., Tsien, C., Brown, P. D., Shankar, L., Galanis, E., Gerstner, E., Van Den Bent, M. J., Burns, T. C., Parney, I. F., Dunn, G., Brastianos, P. K., Lin, N. U., Wen, P. Y. & Ellingson, B. M., Jun 9 2020, In : Neuro-oncology. 22, 6, p. 757-772 16 p.

    Research output: Contribution to journalReview article

  • 2 Scopus citations

    GATA2 Regulates Constitutive PD-L1 and PD-L2 Expression in Brain Tumors

    Fu, Y., Liu, C. J., Kobayashi, D. K., Johanns, T. M., Bowman-Kirigin, J. A., Schaettler, M. O., Mao, D. D., Bender, D., Kelley, D. G., Uppaluri, R., Bi, W. L., Dunn, I. F., Tao, Y., Luo, J., Kim, A. H. & Dunn, G. P., Dec 1 2020, In : Scientific reports. 10, 1, 9027.

    Research output: Contribution to journalArticle

    Open Access
  • Open Access
  • 2 Scopus citations