• 1839 Citations
1994 …2020
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Personal profile

Research interests

Research Interest: Our clinical and translational research is focused on the study of cardiac mechanics in fetal and pediatric cardiac diseases involving computational and imaging modalities at transmural and near-cellular level. We are conducting a quantitative assessment of myocardial tissue and characterize ventricular contractile properties by MRI-based measurements in children born with single ventricle to discern the long-term outcome after reconstructive staged palliation. We evaluated myocardial deformation by two-dimensional speckle tracking echocardiography (2DSE) in a large pediatric cohort to discern the relative influence of aging and cardiac growth on ventricular contractile function. We propose to study cardiac morphologic phenotype in offspring of T2DM pregnancies at mid-trimester gestation and during infancy by the measurements of myocardial deformation and ultrasonic backscatter properties in humans to identify consequence of the adverse intrauterine environment associated with maternal T2DM. Currently we are studying adolescents with No-Alcoholic Fatty Liver Disease/Metabolic Syndrome to evaluate intramyocellular lipid content, myocardial structure and function to discern the phenotypic manifestation and possible mechanistic pathway of cardiovascular involvement in this subpopulation of children

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  • 39 Similar Profiles
Heart Ventricles Medicine & Life Sciences
Echocardiography Medicine & Life Sciences
Premature Infants Medicine & Life Sciences
Heart Diseases Medicine & Life Sciences
Pediatrics Medicine & Life Sciences
Pulmonary Artery Medicine & Life Sciences
Newborn Infant Medicine & Life Sciences
Coronary Vessels Medicine & Life Sciences

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Research Output 1994 2020

Coronary-cameral fistula with double-chambered right ventricle: appearance on cardiac magnetic resonance imaging and 3D printed anatomic modeling

Mokkarala, M., Ballard, D. H., Wesley, R. A., Gutierrez, F. R., Javidan-Nejad, C., Singh, G. K., Woodard, P. K. & Lindley, K. J., Jan 2020, In : Clinical Imaging. 59, 1, p. 84-87 4 p.

Research output: Contribution to journalArticle

Heart Ventricles
Anatomic Models
Magnetic Resonance Imaging
Cardiac Catheters
Doppler Echocardiography
Pulmonary Valve Stenosis

Two-Dimensional Strain is more Precise than Conventional Measures of Left Ventricular Systolic Function in Pediatric Patients

Patel, M. D., Myers, C., Negishi, K., Singh, G. K. & Anwar, S., Jan 1 2020, In : Pediatric Cardiology. 41, 1, p. 186-193 8 p.

Research output: Contribution to journalArticle

Left Ventricular Function
Observer Variation

Anomalous Origin of Left Pulmonary Artery From the Aorta: A Rare Entity in Congenital Heart Disease

Gropler, M. R. F., Dalal, A. S., Bierhals, A. J., Romberg, E., Singh, G. K. & Manning, P. B., Mar 2019, In : Annals of Thoracic Surgery. 107, 3, p. e181-e182

Research output: Contribution to journalArticle

Pulmonary Artery
Heart Diseases
2 Citations (Scopus)

A Novel Noninvasive Index to Characterize Right Ventricle Pulmonary Arterial Vascular Coupling in Children

Levy, P. T., El Khuffash, A., Woo, K. V., Hauck, A., Hamvas, A. & Singh, G. K., Apr 2019, In : JACC: Cardiovascular Imaging. 12, 4, p. 761-763 3 p.

Research output: Contribution to journalLetter

Heart Ventricles
Blood Vessels