Research output per year
Research output per year
Personal profile
Research interests
My research is focused on the role of NOD-like receptor (NLR) family, pyrin-domain containing 3 (NLRP3) inflammasome in the skeleton. The NLRP3 inflammasome is an intracellular protein complex responsible for the maturation of interleukin (IL)-1ß and IL-18. Autosomal dominant gain-of-function mutations of NLRP3 cause cryopyrin-associated periodic syndromes of which neonatal-onset multisystem inflammatory disease (NOMID) is the more severe phenotype. NOMID is characterized by IL-1ß and IL-18-driven systemic inflammation associated with skeletal manifestations, including deformities, leg length discrepancy, epiphyseal overgrowths/lesions, short stature, and low bone mass in 85% of NOMID patients. Thus, activated NLRP3 inflammasome significantly impacts skeletal development and remodeling.
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Effects of the TNFRSF11B Mutation Associated With Calcium Pyrophosphate Deposition Disease in Osteoclastogenesis in a Murine Model
Mitton-Fitzgerald, E., Gohr, C. M., Williams, C. J., Ortiz, A., Mbalaviele, G. & Rosenthal, A. K., Aug 2021, In: Arthritis and Rheumatology. 73, 8, p. 1543-1549 7 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Inhibition of the NLRP3 inflammasome prevents ovarian aging
Navarro-Pando, J. M., Alcocer-Gómez, E., Castejón-Vega, B., Navarro-Villarán, E., Condés-Hervás, M., Mundi-Roldan, M., Muntané, J., Pérez-Pulido, A. J., Bullon, P., Wang, C., Hoffman, H. M., Sanz, A., Mbalaviele, G., Ryffel, B. & Cordero, M. D., Jan 1 2021, In: Science Advances. 7, 1, eabc7409.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
NF-κB-mediated effects on behavior and cartilage pathology in a non-invasive loading model of post-traumatic osteoarthritis
Berke, I. M., Jain, E., Yavuz, B., McGrath, T., Chen, L., Silva, M. J., Mbalaviele, G., Guilak, F., Kaplan, D. L. & Setton, L. A., Feb 2021, In: Osteoarthritis and Cartilage. 29, 2, p. 248-256 9 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
NLRP3 inflammasome activation triggers gasdermin D–independent inflammation
Wang, C., Yang, T., Xiao, J., Xu, C., Alippe, Y., Sun, K., Kanneganti, T. D., Monahan, J. B., Abu-Amer, Y., Lieberman, J. & Mbalaviele, G., 2021, In: Science immunology. 6, 64, eabj3859.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Hematopoietic stem cell transplantation-induced bone remodeling in autosomal recessive osteopetrosis: Interaction between skeleton and hematopoietic and sensory nervous systems
Maximova, N., Zennaro, F., Gregori, M., Boz, G., Zanon, D. & Mbalaviele, G., Jan 2020, In: Bone. 130, 115144.Research output: Contribution to journal › Article › peer-review
3 Scopus citations