Research Output per year
Research Output per year
Personal profile
Research interests
My research is focused on the role of NOD-like receptor (NLR) family, pyrin-domain containing 3 (NLRP3) inflammasome in the skeleton. The NLRP3 inflammasome is an intracellular protein complex responsible for the maturation of interleukin (IL)-1ß and IL-18. Autosomal dominant gain-of-function mutations of NLRP3 cause cryopyrin-associated periodic syndromes of which neonatal-onset multisystem inflammatory disease (NOMID) is the more severe phenotype. NOMID is characterized by IL-1ß and IL-18-driven systemic inflammation associated with skeletal manifestations, including deformities, leg length discrepancy, epiphyseal overgrowths/lesions, short stature, and low bone mass in 85% of NOMID patients. Thus, activated NLRP3 inflammasome significantly impacts skeletal development and remodeling.
Fingerprint
Dive into the research topics where Gabriel Mbalaviele is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 16 Similar Profiles
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output
-
Hematopoietic stem cell transplantation-induced bone remodeling in autosomal recessive osteopetrosis: Interaction between skeleton and hematopoietic and sensory nervous systems
Maximova, N., Zennaro, F., Gregori, M., Boz, G., Zanon, D. & Mbalaviele, G., Jan 2020, In: Bone. 130, 115144.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO
Adapala, N. S., Swarnkar, G., Arra, M., Shen, J., Mbalaviele, G., Ke, K. & Abu-Amer, Y., Mar 2020, In: eLife. 9, e56095.Research output: Contribution to journal › Article › peer-review
Open Access -
LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
Arra, M., Swarnkar, G., Ke, K., Otero, J. E., Ying, J., Duan, X., Maruyama, T., Rai, M. F., O’Keefe, R. J., Mbalaviele, G., Shen, J. & Abu-Amer, Y., Dec 1 2020, In: Nature communications. 11, 1, 3427.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Myeloid-specific Asxl2 deletion limits diet-induced obesity by regulating energy expenditure
Zou, W., Rohatgi, N., Brestoff, J. R., Moley, J. R., Li, Y., Williams, J. W., Alippe, Y., Pan, H., Pietka, T. A., Mbalaviele, G., Newberry, E. P., Davidson, N. O., Dey, A., Shoghi, K. I., Head, R. D., Wickline, S. A., Randolph, G. J., Abumrad, N. A. & Teitelbaum, S. L., May 1 2020, In: Journal of Clinical Investigation. 130, 5, p. 2644-2656 13 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
PARP1 Hinders Histone H2B Occupancy at the NFATc1 Promoter to Restrain Osteoclast Differentiation
Wang, C., Xiao, J., Nowak, K., Gunasekera, K., Alippe, Y., Speckman, S., Yang, T., Kress, D., Abu-Amer, Y., Hottiger, M. O. & Mbalaviele, G., Apr 1 2020, In: Journal of Bone and Mineral Research. 35, 4, p. 776-788 13 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations