Personal profile
Research interests
The Arnold Lab is broadly focused on studying the molecular mechanisms underlying neuronal loss in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other TDP-43 proteinopathies, as well as identifying new biomarkers and therapeutic targets for these disorders
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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Pinpointing protein as the problem
Arnold, F. J. & La Spada, A. R., Feb 2026, In: Science. 391, 6785, p. 555-556 2 p.Research output: Contribution to journal › Article › peer-review
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Transposable element–gene chimera cartography, origination and role in enhancing transcriptome plasticity
Cheon, Y., Alvstad, E. G., Torre, D., Quach, D. T., Nguyen, J., Hyun, K., Zhou, M., Yu, T., Liu, L., Yoon, Y., Reese, F., Faraone, L., Li, Y., Arnold, F. J., Fstkchyan, Y. S., Basu, U., Kvon, E., Valente, E. M., Ho, J. S. Y. & Byun, M. & 5 others, , Mar 2026, In: Nature Structural and Molecular Biology. 33, 3, p. 448-463 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Multi-omic quantitative trait loci link tandem repeat size variation to gene regulation in human brain
Cui, Y., Arnold, F. J., Li, J. S., Wu, J., Wang, D., Philippe, J., Colwin, M. R., Michels, S., Chen, C., Sallam, T., Thompson, L. M., La Spada, A. R. & Li, W., Feb 2025, In: Nature Genetics. 57, 2, p. 369-378 10 p., 2927.Research output: Contribution to journal › Article › peer-review
Open Access9 Link opens in a new tab Scopus citations -
TDP-43 dysregulation of polyadenylation site selection is a defining feature of RNA misprocessing in amyotrophic lateral sclerosis and frontotemporal dementia
Arnold, F. J., Cui, Y., Michels, S., Colwin, M. R., Stockford, C. M., Ye, W., Jawahar, V. M., Jansen-West, K., Philippe, J., Gulia, R., Gou, Y., Tam, O. H., Menon, S., Situ, W. G., Cazarez, S. L., Zandi, A., Ehsani, K. C. K., Howard, S., Dickson, D. W. & Hammell, M. G. & 4 others, , Jun 2 2025, In: Journal of Clinical Investigation. 135, 11, e182088.Research output: Contribution to journal › Article › peer-review
Open Access15 Link opens in a new tab Scopus citations -
Differentially disrupted spinal cord and muscle energy metabolism in spinal and bulbar muscular atrophy
DeBartolo, D., Arnold, F. J., Liu, Y., Molotsky, E., Tang, H. Y. & Merry, D. E., 2024, In: JCI Insight. 9, 7, e178048.Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Scopus citations