• 8207
    Citations
1997 …2025

Research activity per year

Personal profile

Research interests

Our laboratory studies the genetic determinants and pathogenic mechanisms of urogenital diseases with the goal of improving diagnostic and therapeutic strategies targeting these diseases. We have been creating and utilizing an array of experimental and disease models in mice to study the involvement of a number of pathways (such as the calcineurin/NFAT and Wnt signaling pathways) in urogenital diseases (such as Congenital anomalies of the kidney and the urinary tract (CAKUT), glomerular diseases, and prostate cancer). We use a multi-disciplinary approach, including cutting edge genome technologies, to study the mechanisms leading from defined genetic changes to the development of benign and malignant diseases in urogenital organs. While we take advantage of the in vivo systems for studying the genetic, physiological, and pathological aspects of these diseases, we also performed experiments in ex vivo and in vitro systems to study molecular interactions and cellular behaviors, using molecular biology, cell biology and biochemistry techniques. In addition to answering specific questions with clinical relevance, we are also keen on developing new genetic tools for the research community, such as new tissue-specific Cre transgenes and conditionally controllable transgenic mouse lines.

Mentoring

We are committed to building a diverse and inclusive workplace. The research environment in our lab is highly collaborative, intellectually stimulating, and enjoyable. 

Available to Mentor:

  • PhD/MSTP Students

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Collaborations and top research areas from the last five years

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  • DeST-OT: Alignment of spatiotemporal transcriptomics data

    Halmos, P., Liu, X., Gold, J., Chen, F., Ding, L. & Raphael, B. J., Feb 19 2025, In: Cell Systems. 16, 2, 101160.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1 Scopus citations
  • Elevated p16Ink4a Expression Enhances Tau Phosphorylation in Neurons Differentiated From Human-Induced Pluripotent Stem Cells

    Holloway, K., Neherin, K., Song, Y., Sato, K., Houston, A., Chen, F., Ding, L. & Zhang, H., May 2025, In: Aging Cell. 24, 5, e14472.

    Research output: Contribution to journalArticlepeer-review

  • Multi-omic and spatial analysis of mouse kidneys highlights sex-specific differences in gene regulation across the lifespan

    Chen, S., Liu, R., Mo, C. K., Wendl, M. C., Houston, A., Lal, P., Zhao, Y., Caravan, W., Shinkle, A. T., Abedin-Do, A., Naser Al Deen, N., Sato, K., Li, X., Targino da Costa, A. L. N., Li, Y., Karpova, A., Herndon, J. M., Artyomov, M. N., Rubin, J. B. & Jain, S. & 4 others, Li, X., Stewart, S. A., Ding, L. & Chen, F., May 2025, In: Nature Genetics. 57, 5, p. 1213-1227 15 p., 1396.

    Research output: Contribution to journalArticlepeer-review

  • Comprehensive proteogenomic characterization of rare kidney tumors

    Clinical Proteomic Tumor Analysis Consortium, Li, G. X., Chen, L., Hsiao, Y., Mannan, R., Zhang, Y., Luo, J., Petralia, F., Cho, H., Hosseini, N., Leprevost, F. D. V., Calinawan, A., Li, Y., Anand, S., Dagar, A., Geffen, Y., Kumar-Sinha, C., Chugh, S., Le, A. & Ponce, S. & 83 others, Guo, S., Zhang, C., Schnaubelt, M., Al Deen, N. N., Chen, F., Caravan, W., Houston, A., Hopkins, A., Newton, C. J., Wang, X., Polasky, D. A., Haynes, S., Yu, F., Jing, X., Chen, S., Robles, A. I., Mesri, M., Thiagarajan, M., An, E., Getz, G. A., Linehan, W. M., Hostetter, G., Jewell, S. D., Chan, D. W., Wang, P., Omenn, G. S., Mehra, R., Ricketts, C. J., Ding, L., Chinnaiyan, A. M., Cieslik, M. P., Dhanasekaran, S. M., Zhang, H., Nesvizhskii, A. I., Lazar, A. J., Paulovich, A. G., Antczak, A., Green, A., Ma'ayan, A., Pruetz, B., Zhang, B., Reva, B., Druker, B. J., Goldthwaite, C. A., Birger, C., Mani, D. R., Chesla, D., Fenyö, D., Schadt, E. E., Wilson, G., Kołodziejczak, I., John, I., Hafron, J., Vo, J., Zaalishvili, K., Ketchum, K. A., Rodland, K. D., Nyce, K., Wiznerowicz, M., Domagalski, M. J., Anurag, M., Borucki, M., Gillette, M. A., Birrer, M. J., Edwards, N. J., Vatanian, N., VanderKolk, P., McGarvey, P. B., Dhir, R., Thangudu, R. R., Crispen, R., Smith, R. D., Payne, S. H., Cottingham, S., Cai, S., Carr, S. A., Liu, T., Le, T., Ma, W., Zhang, X., Lu, Y., Shutack, Y. & Zhang, Z., May 21 2024, In: Cell Reports Medicine. 5, 5, 101547.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    13 Scopus citations
  • DeST-OT: Alignment of Spatiotemporal Transcriptomics Data

    Halmos, P., Liu, X., Gold, J., Chen, F., Ding, L. & Raphael, B. J., 2024, Research in Computational Molecular Biology - 28th Annual International Conference, RECOMB 2024, Proceedings. Ma, J. (ed.). Springer Science and Business Media Deutschland GmbH, p. 434-437 4 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 14758 LNCS).

    Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

    2 Scopus citations