Faisal Fa'ak

2025

Characterizing Chronic Cutaneous Immune-Related Adverse Events Following Immune Checkpoint Inhibitors

Fletcher, K. A., Goodman, R. S., Lawless, A., Woodford, R., Fa'Ak, F., Tipirneni, A., Patrinely, J. R., Yeoh, H. L., Rapisuwon, S., Haydon, A., Osman, I., Mehnert, J. M., Long, G. V., Sullivan, R. J., Carlino, M. S., Menzies, A. M., Dewan, A. K. & Johnson, D. B., 2025, (Accepted/In press) In: JAMA Dermatology.

Research output: Contribution to journal › Article › peer-review

2024

Kinase Insert Domain Receptor Q472H Pathogenic Germline Variant Impacts Melanoma Tumor Growth and Patient Treatment Outcomes

Ibrahim, M., Illa-Bochaca, I., Fa’ak, F., Monson, K. R., Ferguson, R., Lyu, C., Vega-Saenz de Miera, E., Johannet, P., Chou, M., Mastroianni, J., Darvishian, F., Kirchhoff, T., Zhong, J., Krogsgaard, M. & Osman, I., Jan 2024, In: Cancers. 16, 1, 18.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Extended Follow-Up of Chronic Immune-Related Adverse Events Following Adjuvant Anti-PD-1 Therapy for High-Risk Resected Melanoma

Goodman, R. S., Lawless, A., Woodford, R., Fa'Ak, F., Tipirneni, A., Patrinely, J. R., Yeoh, H. L., Rapisuwon, S., Haydon, A., Osman, I., Mehnert, J. M., Long, G. V., Sullivan, R. J., Carlino, M. S., Menzies, A. M. & Johnson, D. B., Aug 3 2023, In: JAMA Network Open. 6, 8, p. E2327145

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Selective immune suppression using interleukin-6 receptor inhibitors for management of immune-related adverse events

Fa'ak, F., Buni, M., Falohun, A., Lu, H., Song, J., Johnson, D. H., Zobniw, C. M., Trinh, V. A., Awiwi, M. O., Tahon, N. H., Elsayes, K. M., Ludford, K., Montazari, E. J., Chernis, J., Dimitrova, M., Sandigursky, S., Sparks, J. A., Abu-Shawer, O., Rahma, O. & Thanarajasingam, U. & 13 others, Zeman, A. M., Talukder, R., Singh, N., Chung, S. H., Grivas, P., Daher, M., Abudayyeh, A., Osman, I., Weber, J., Tayar, J. H., Suarez-Almazor, M. E., Abdel-Wahab, N. & Diab, A., Jun 16 2023, In: Journal for ImmunoTherapy of Cancer. 11, 6, e006814.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

2022

Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity

Hailemichael, Y., Johnson, D. H., Abdel-Wahab, N., Foo, W. C., Bentebibel, S. E., Daher, M., Haymaker, C., Wani, K., Saberian, C., Ogata, D., Kim, S. T., Nurieva, R., Lazar, A. J., Abu-Sbeih, H., Fa'ak, F., Mathew, A., Wang, Y., Falohun, A., Trinh, V. & Zobniw, C. & 17 others, Spillson, C., Burks, J. K., Awiwi, M., Elsayes, K., Soto, L. S., Melendez, B. D., Davies, M. A., Wargo, J., Curry, J., Yee, C., Lizee, G., Singh, S., Sharma, P., Allison, J. P., Hwu, P., Ekmekcioglu, S. & Diab, A., May 9 2022, In: Cancer Cell. 40, 5, p. 509-523.e6

Research output: Contribution to journal › Article › peer-review

Open Access

204 Scopus citations

LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade

Hickman, A., Koetsier, J., Kurtanich, T., Nielsen, M. C., Winn, G., Wang, Y., Bentebibel, S. E., Shi, L., Punt, S., Williams, L., Haymaker, C., Chesson, C. B., Fa’ak, F., Dominguez, A. L., Jones, R., Kuiatse, I., Caivano, A. R., Khounlo, S., Warier, N. D. & Marathi, U. & 10 others, Market, R. V., Biediger, R. J., Craft, J. W., Hwu, P., Davies, M. A., Woodside, D. G., Vanderslice, P., Diab, A., Overwijk, W. W. & Hailemichael, Y., Jul 1 2022, In: Journal of Clinical Investigation. 132, 13, e154152.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Outcomes of Breast Cancer Patients Treated with Chemotherapy, Biologic Therapy, Endocrine Therapy, or Active Surveillance During the COVID-19 Pandemic

Marks, D. K., Budhathoki, N., Kucharczyk, J., Fa’ak, F., D’Abreo, N., Kwa, M., Plasilova, M., Dhage, S., Soe, P. P., Becker, D., Hindenburg, A., Lee, J., Winner, M., Okpara, C., Daly, A., Shah, D., Ramdhanny, A., Meyers, M., Oratz, R. & Speyer, J. & 4 others, Novik, Y., Schnabel, F., Jones, S. A. & Adams, S., Feb 2022, In: Oncologist. 27, 2, p. 89-96 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2021

Cancer immunotherapy: Overview of immune checkpoint inhibitors

Fa'ak, F. & Diab, A., Feb 16 2021, Rheumatic Diseases and Syndromes Induced by Cancer Immunotherapy: A Handbook for Diagnosis and Management. Springer International Publishing, p. 31-47 17 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Posterior Reversible Encephalopathy Syndrome Induced by Scleroderma Renal Crisis in a Patient with Undiagnosed Scleroderma

Fa'Ak, F., Al-Bahadili, H., Shah, N. & Julka, K., Dec 1 2021, In: Journal of Clinical Rheumatology. 27, 8S, p. S825-S826

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Post-transplantation cyclophosphamide reduces the incidence of acute graft-versus-host disease in patients with acute myeloid leukemia/myelodysplastic syndromes who receive immune checkpoint inhibitors after allogeneic hematopoietic stem cell transplantation

Saberian, C., Abdel-Wahab, N., Abudayyeh, A., Rafei, H., Joseph, J., Rondon, G., Whited, L., Gruschkus, S., Fa'Ak, F., Daher, M., Knape, C., Safa, H., Shoukier, M., Suarez-Almazor, M. E., Marcotulli, M., Ludford, K., Gulbis, A. M., Konopleva, M., Ohanian, M. & Ravandi, F. & 9 others, Garcia-Manero, G., Oran, B., Popat, U. R., Mehta, R., Alousi, A. M., Daver, N., Champlin, R., Diab, A. & Al-Atrash, G., Feb 26 2021, In: Journal for ImmunoTherapy of Cancer. 9, 2, e001818.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2020

Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy

Sharma, M., Khong, H., Fa’ak, F., Bentebibel, S. E., Janssen, L. M. E., Chesson, B. C., Creasy, C. A., Forget, M. A., Kahn, L. M. S., Pazdrak, B., Karki, B., Hailemichael, Y., Singh, M., Vianden, C., Vennam, S., Bharadwaj, U., Tweardy, D. J., Haymaker, C., Bernatchez, C. & Huang, S. & 11 others, Rajapakshe, K., Coarfa, C., Hurwitz, M. E., Sznol, M., Hwu, P., Hoch, U., Addepalli, M., Charych, D. H., Zalevsky, J., Diab, A. & Overwijk, W. W., Dec 1 2020, In: Nature communications. 11, 1, 661.

Research output: Contribution to journal › Article › peer-review

Open Access

133 Scopus citations

Systematic review of observational studies reporting antiphospholipid antibodies in patients with solid tumors

Abdel-Wahab, N., Tayar, J. H., Fa’ak, F., Sharma, G., Lopez-Olivo, M. A., Yousif, A., Shagroni, T., Al-Hawamdeh, S., Rojas-Hernandez, C. M. & Suarez-Almazor, M. E., Apr 28 2020, In: Blood Advances. 4, 8, p. 1746-1755 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

18 Scopus citations

2019

A case report of atezolizumab induced tumor lysis syndrome

Fa’ak, F., Vanegas, D. & Osei, K. M., 2019, In: American Journal of Case Reports. 20, p. 785-789 5 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Immune checkpoint inhibitor related myasthenia gravis: Single center experience and systematic review of the literature

Safa, H., Johnson, D. H., Trinh, V. A., Rodgers, T. E., Lin, H., Suarez-Almazor, M. E., Fa'Ak, F., Saberian, C., Yee, C., Davies, M. A., Tummala, S., Woodman, K., Abdel-Wahab, N. & Diab, A., Nov 21 2019, In: Journal for ImmunoTherapy of Cancer. 7, 1, 319.

Research output: Contribution to journal › Article › peer-review

Open Access

191 Scopus citations

2018

Cancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy

Hailemichael, Y., Woods, A., Fu, T., He, Q., Nielsen, M. C., Hasan, F., Roszik, J., Xiao, Z., Vianden, C., Khong, H., Singh, M., Sharma, M., Faak, F., Moore, D., Dai, Z., Anthony, S. M., Schluns, K. S., Sharma, P., Engelhard, V. H. & Overwijk, W. W., Apr 2 2018, In: Journal of Clinical Investigation. 128, 4, p. 1338-1354 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

69 Scopus citations

2017

Erratum to: "A case report of Grover's disease from immunotherapy-a skin toxicity induced by inhibition of CTLA-4 but not PD-1" [J Immunother Cancer. (2016), 4, (55)], DOI: 10.1186/s40425-016-0157-6

Uemura, M., Fa'ak, F., Haymaker, C., McQuail, N., Sirmans, E., Hudgens, C. W., Barbara, L., Bernatchez, C., Curry, J. L., Hwu, P., Tetzlaff, M. T. & Diab, A., Jan 18 2017, In: Journal for ImmunoTherapy of Cancer. 5, 1, 7.

Research output: Contribution to journal › Comment/debate

Open Access

2 Scopus citations

Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain

Singh, M., Vianden, C., Cantwell, M. J., Dai, Z., Xiao, Z., Sharma, M., Khong, H., Jaiswal, A. R., Faak, F., Hailemichael, Y., Janssen, L. M. E., Bharadwaj, U., Curran, M. A., Diab, A., Bassett, R. L., Tweardy, D. J., Hwu, P. & Overwijk, W. W., Dec 1 2017, In: Nature communications. 8, 1, 1447.

Research output: Contribution to journal › Article › peer-review

Open Access

66 Scopus citations

2016

A case report of Grover's disease from immunotherapy-a skin toxicity induced by inhibition of CTLA-4 but not PD-1

Uemura, M., Faisal, F., Haymaker, C., McQuail, N., Sirmans, E., Hudgens, C. W., Barbara, L., Bernatchez, C., Curry, J. L., Hwu, P., Tetzlaff, M. T. & Diab, A., Sep 20 2016, In: Journal for ImmunoTherapy of Cancer. 4, 1, 55.

Research output: Contribution to journal › Article › peer-review

Open Access

47 Scopus citations

Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis

Valenzuela, N., Fan, Q., Fa'ak, F., Soibam, B., Nagandla, H., Liu, Y., Schwartz, R. J., McConnell, B. K. & Stewart, M. D., Mar 1 2016, In: DMM Disease Models and Mechanisms. 9, 3, p. 335-345 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Direct measurement of left atrial pressure: During routine transradial catheterization

Fa’ak, F., Shabaneh, B. & Younis, G., Dec 2016, In: Texas Heart Institute journal. 43, 6, p. 503-506 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Mesp1 Marked Cardiac Progenitor Cells Repair Infarcted Mouse Hearts

Liu, Y., Chen, L., Diaz, A. D., Benham, A., Xu, X., Wijaya, C. S., Fa'Ak, F., Luo, W., Soibam, B., Azares, A., Yu, W., Lyu, Q., Stewart, M. D., Gunaratne, P., Cooney, A., McConnell, B. K. & Schwartz, R. J., Aug 19 2016, In: Scientific reports. 6, 31457.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Faisal Fa'ak

Research output

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